MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells

Tsuyama, Jun; Bunt, Jens; Richards, Linda J.; Iwanari, Hiroko; Mochizuki, Yasuhiro; Hamakubo, Takao; Shimazaki, Takuya; Okano, Hideyuki

doi:10.1016/j.stemcr.2015.06.006

Cited by 47 publications

(33 citation statements)

References 66 publications

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“…In this study, the neuronal differentiation was unaffected by the ischemic environment. Ischemia promotes interleukin‐6 (IL‐6) expression in the ipsilesional hemisphere (Gertz et al, ), and IL‐6–related protein is known as a strong inducer of gliogenesis in NSCs (Tsuyama et al, ). However, despite being attracted by and migrating toward the ischemic border, none of the cells in our grafts differentiated into astrocytes.…”

Section: Discussionmentioning

confidence: 99%

Transplantation of feeder‐free human induced pluripotent stem cell–derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia

Hermanto

Sunohara

Faried

et al. 2017

J of Neuroscience Research

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The use of human induced pluripotent stem cells (hiPSCs) eliminates the ethical issues associated with fetal or embryonic materials, thus allowing progress in cell therapy research for ischemic stroke. Strict regulation of cell therapy development requires the xeno-free condition to eliminate clinical complications. Maintenance of hiPSCs with feeder-free condition presents a higher degree of spontaneous differentiation in comparison with conventional cultures. Therefore, feeder-free derivation might be not ideal for developing transplantable hiPSC derivatives. We developed the feeder-free condition for differentiation of cortical neurons from hiPSCs. Then, we evaluated the cells' characteristics upon transplantation into the sham and focal brain ischemia on adult male Wistar rats. Grafts in lesioned brains demonstrated polarized reactivity toward the ischemic border, indicated by directional preferences in axonal outgrowth and cellular migration, with no influence on graft survival. Following the transplantation, forelimb asymmetry was better restored compared with controls. Herein, we provide evidence to support the use of the xeno-free condition for the development of cell therapy for ischemic stroke.

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Section: Discussionmentioning

confidence: 99%

Transplantation of feeder‐free human induced pluripotent stem cell–derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia

Hermanto

Sunohara

Faried

et al. 2017

J of Neuroscience Research

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“…miR-17 and its paralog miR-106 are able to prevent this switch during early development (Naka-Kaneda et al, 2014), and gliogenic factors are only expressed when the expression of these miRNAs gradually decreases during development, and this is then followed by the acquisition of gliogenic competence and glial differentiation (Naka-Kaneda et al, 2014). Furthermore, miR-153, which is highly expressed during early embryonic development, suppresses gliogenesisinducing factors [nuclear factor I (NFI) A and B] and prevents gliogenesis (Tsuyama et al, 2015). Once miR-153 levels are decreased, NFIA/B accumulates and NPCs acquire gliogenic competence (Tsuyama et al, 2015).…”

Section: Gliogenesismentioning

confidence: 99%

“…Furthermore, miR-153, which is highly expressed during early embryonic development, suppresses gliogenesisinducing factors [nuclear factor I (NFI) A and B] and prevents gliogenesis (Tsuyama et al, 2015). Once miR-153 levels are decreased, NFIA/B accumulates and NPCs acquire gliogenic competence (Tsuyama et al, 2015). Additional miRNAs that are important in glial cell lineage decisions include let-7 family members (Gökbuget et al, 2015;Patterson et al, 2014;Shenoy et al, 2015).…”

Section: Gliogenesismentioning

confidence: 99%

MicroRNAs in neural development: from master regulators to fine-tuners

2017

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The proper formation and function of neuronal networks is required for cognition and behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to neurodevelopmental disorders such as autism, schizophrenia or intellectual disability. It is wellestablished that transcriptional programs play major roles in neural circuit development. However, in recent years, post-transcriptional control of gene expression has emerged as an additional, and probably equally important, regulatory layer. In particular, it has been shown that microRNAs (miRNAs), an abundant class of small regulatory RNAs, can regulate neuronal circuit development, maturation and function by controlling, for example, local mRNA translation. It is also becoming clear that miRNAs are frequently dysregulated in neurodevelopmental disorders, suggesting a role for miRNAs in the etiology and/or maintenance of neurological disease states. Here, we provide an overview of the most prominent regulatory miRNAs that control neural development, highlighting how they act as 'master regulators' or 'fine-tuners' of gene expression, depending on context, to influence processes such as cell fate determination, cell migration, neuronal polarization and synapse formation.

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“…Another study demonstrated that activation of NF κ B signaling directly enhanced the transcription of NFIA in glioblastoma cells . The expression of NFIB was also regulated by microRNAs, such as miR‐372/373 , miR‐153 , miR‐365 , and miR‐124 . In adult neural progenitors, the Pax6–BAF complex transcriptionally upregulated NFIB .…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of NFIA and NFIB in esophageal squamous carcinoma and esophagogastric junction adenocarcinoma

Yang

Zhou

Chen³

et al. 2018

Cancer Medicine

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The nuclear factor I (NFI) family members, especially NFIA and NFIB, play essential roles in cancers. The roles of NFIA and NFIB in esophageal squamous cell carcinoma (ESCC) and esophagogastric junction adenocarcinoma (EJA) remain poorly known. This study aimed to determine the expression of NFIA and NFIB in ESCC and EJA and elucidate their prognostic significance. The expression of NFIA and NFIB was examined in 163 ESCC samples and 26 EJA samples by immunohistochemistry. The results showed that high NFIA expression correlated significantly with poor differentiation, lymph node metastasis, and advanced TNM stage in patients with ESCC. High NFIB expression only correlated with poor differentiation in patients with ESCC. Survival analysis showed that NFIA but not NFIB associated with short overall survival (OS) and disease‐free survival (DFS) of patients with ESCC. On the other hand, high NFIB expression correlated with lymph node metastasis, advanced TNM stage, and short OS and DFS in patients with EJA. Finally, multivariate analysis demonstrated that high NFIA expression was an independent prognostic factor for ESCC. Taken together, these results demonstrated that NFIA and NFIB could serve as prognostic indicators for ESCC and EJA, respectively.

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MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells

Cited by 47 publications

References 66 publications

Transplantation of feeder‐free human induced pluripotent stem cell–derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia

Transplantation of feeder‐free human induced pluripotent stem cell–derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia

MicroRNAs in neural development: from master regulators to fine-tuners

Prognostic significance of NFIA and NFIB in esophageal squamous carcinoma and esophagogastric junction adenocarcinoma

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