MicroRNA-150 modulates intracellular Ca
                2+
               levels in naïve CD8+ T cells by targeting TMEM20

Kim, Tae-Don; Jung, Hong-Ryul; Seo, Sang Hwan; Oh, Se Chan; Ban, Young Ho; Tan, Xiaoxia; Kim, Jung Min; Lee, Jangwook; Koh, Duk Su; Jung, Hye Young; Park, Young Jun; Yoon, Suk Ran; Doh, Junsang; Ha, Sang Jun; Choi, Inpyo; Greenberg, Philip D.

doi:10.1038/s41598-017-02697-x

Cited by 11 publications

(4 citation statements)

References 41 publications

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“…The next step will logically be to use this knowledge in order to target SOCE, and thus treat human patients afflicted with diseases linked to SOCE aberrant activity. In a recent study, miR-150 was shown as an endogenous inhibitor of POST, important for CD 8+ T cells activation [96]. According to this work, targeting of SOCE partner protein POST with miR-150 could therefore represent a new treatment against auto-immune diseases.…”

Section: Capacitative Calcium Entry (Cce) and Associated Proteinsmentioning

confidence: 82%

Partners in Crime: Towards New Ways of Targeting Calcium Channels

Noyer

Lemonnier

Mariot

et al. 2019

IJMS

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The characterization of calcium channel interactome in the last decades opened a new way of perceiving ion channel function and regulation. Partner proteins of ion channels can now be considered as major components of the calcium homeostatic mechanisms, while the reinforcement or disruption of their interaction with the channel units now represents an attractive target in research and therapeutics. In this review we will focus on the targeting of calcium channel partner proteins in order to act on the channel activity, and on its consequences for cell and organism physiology. Given the recent advances in the partner proteins’ identification, characterization, as well as in the resolution of their interaction domain structures, we will develop the latest findings on the interacting proteins of the following channels: voltage-dependent calcium channels, transient receptor potential and ORAI channels, and inositol 1,4,5-trisphosphate receptor.

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Section: Capacitative Calcium Entry (Cce) and Associated Proteinsmentioning

confidence: 82%

Partners in Crime: Towards New Ways of Targeting Calcium Channels

Noyer

Lemonnier

Mariot

et al. 2019

IJMS

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“…Since this is essential to induce the expression of activation-associated genes, miR-150-induced reduction in TMEM20 allows naïve CD8 + T cells to express anergy-inducing genes, such as Casitas B lineage lymphoma b (Cbl-b), Egr2 and p27. These findings suggest the central role of TCR-mediated intracellular Ca 2+ regulation in naïve CD8 + T cells [72].…”

Section: Stim1 Scaffold Proteinsmentioning

confidence: 72%

Plasma Membrane and Organellar Targets of STIM1 for Intracellular Calcium Handling in Health and Neurodegenerative Diseases

Tedeschi

Russa

Franco

et al. 2021

Cells

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Located at the level of the endoplasmic reticulum (ER) membrane, stromal interacting molecule 1 (STIM1) undergoes a complex conformational rearrangement after depletion of ER luminal Ca2+. Then, STIM1 translocates into discrete ER-plasma membrane (PM) junctions where it directly interacts with and activates plasma membrane Orai1 channels to refill ER with Ca2+. Furthermore, Ca2+ entry due to Orai1/STIM1 interaction may induce canonical transient receptor potential channel 1 (TRPC1) translocation to the plasma membrane, where it is activated by STIM1. All these events give rise to store-operated calcium entry (SOCE). Besides the main pathway underlying SOCE, which mainly involves Orai1 and TRPC1 activation, STIM1 modulates many other plasma membrane proteins in order to potentiate the influxof Ca2+. Furthermore, it is now clear that STIM1 may inhibit Ca2+ currents mediated by L-type Ca2+ channels. Interestingly, STIM1 also interacts with some intracellular channels and transporters, including nuclear and lysosomal ionic proteins, thus orchestrating organellar Ca2+ homeostasis. STIM1 and its partners/effectors are significantly modulated in diverse acute and chronic neurodegenerative conditions. This highlights the importance of further disclosing their cellular functions as they might represent promising molecular targets for neuroprotection.

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“…It is proved that this effect depends on the regulation of Myc and Bcl-2 by miR150 (1). These studies reveal that miR150 relates to the development, maturity, and cytotoxicity of NK cells (9). In our study, if NK cells had miR150 reduction, the function for disturbing target cells of NK cells would be enhanced.…”

Section: Discussionmentioning

confidence: 99%

Reduction of T Cells and Hsa-miR150-5p in Female Canoeing Athletes: Preliminary Evidence Between Exercise Training and Immune

Xiao¹,

Yang²,

Xiao³

et al. 2022

Journal of Strength and Conditioning Research

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Xiao, F, Yang, Y, Xiao, L, Xia, Z, Wang, L, Yang, K, and Wang, S. Reduction of T cells and hsa-miR150-5p in female canoeing athletes: Preliminary evidence between exercise training and immune. J Strength Cond Res 36(11): e106–e113, 2022—This article aims to reveal the alteration of immune profile in teenage canoeing athletes, by which applies a clue for regulation of exercise on human immune. Thirty-one teenagers of female canoeing athletes and age-matched subjects participated in this research. Peripheral leukocytes' microRNAs (miRNAs) were analyzed using Agilent human microRNA 2.0 and gene software. The miRNA candidates were quantified by reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR). The percentages of various lymphocytes were tested using flow cytometry. There were 6 miRNAs (hsa-miR150-5p, 31-5p, 3659, 4419a, 650, and 8485) lower in canoeing athletes, and the reduction of miR-150 was identified by RT-qPCR (p = 0.021). Canoeing athletes had lower percent of CD3+ T cells than the subjects with no exercise training had (p < 0.001), but the ratio of CD4+ to CD8+ and the percent of CD4+ T cells and CD8+ T cells showed no significant difference between these 2 groups. T cells and hsa-miR150-5p are sensitive to the long-time heavy exercise training, and the exercise for winning competition regulates the immune system by inhibiting T cells and hsa-miR150-5p.

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MicroRNA-150 modulates intracellular Ca 2+ levels in naïve CD8+ T cells by targeting TMEM20

Cited by 11 publications

References 41 publications

Partners in Crime: Towards New Ways of Targeting Calcium Channels

Partners in Crime: Towards New Ways of Targeting Calcium Channels

Plasma Membrane and Organellar Targets of STIM1 for Intracellular Calcium Handling in Health and Neurodegenerative Diseases

Reduction of T Cells and Hsa-miR150-5p in Female Canoeing Athletes: Preliminary Evidence Between Exercise Training and Immune

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