MicroRNA-149: A review of its role in digestive system cancers

Wang, Ning; Zhou, Peng; Chen, Yigang; Qu, Huiheng; Lu, Keyu; Xia, Jiazeng

doi:10.1016/j.prp.2020.153266

Cited by 10 publications

(9 citation statements)

References 91 publications

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“…Recent reports have shown that the incidence rate and mortality rate of digestive system cancer are still rising, and it has become a global health problem that seriously threatens human health ( Smyth et al, 2017 ; Bray et al, 2018 ; Villanueva, 2019 ; Sung et al, 2021 ). At the same time, some studies have shown that digestive system cancers have some pathogenesis factors in common ( Zhang et al, 2018 ; Wang et al, 2020 ). Therefore, comparing the pathogenesis of various digestive system cancers and the effect of anticancer agents on cancers of the digestive system may provide a basis for the discovery of more effective digestive system anti-tumor therapies.…”

Section: Introductionmentioning

confidence: 99%

Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment

Yang

Luo

et al. 2022

Front. Pharmacol.

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Allicin is the main active ingredient in freshly-crushed garlic and some other allium plants, and its anticancer effect on cancers of digestive system has been confirmed in many studies. The aim of this review is to summarize epidemiological studies and in vitro and in vivo investigations on the anticancer effects of allicin and its secondary metabolites, as well as their biological functions. In epidemiological studies of esophageal cancer, liver cancer, pancreatic cancer, and biliary tract cancer, the anticancer effect of garlic has been confirmed consistently. However, the results obtained from epidemiological studies in gastric cancer and colon cancer are inconsistent. In vitro studies demonstrated that allicin and its secondary metabolites play an antitumor role by inhibiting tumor cell proliferation, inducing apoptosis, controlling tumor invasion and metastasis, decreasing angiogenesis, suppressing Helicobacter pylori, enhancing the efficacy of chemotherapeutic drugs, and reducing the damage caused by chemotherapeutic drugs. In vivo studies further demonstrate that allicin and its secondary metabolites inhibit cancers of the digestive system. This review describes the mechanisms against cancers of digestive system and therapeutic potential of allicin and its secondary metabolites.

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Section: Introductionmentioning

confidence: 99%

Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment

Yang

Luo

et al. 2022

Front. Pharmacol.

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“…Currently, the miRNAs known to regulate autophagy in BC include miR-142-3p ( 42 ), miR-27a ( 43 ), and miR-1910-3p ( 44 ). MiR-149-3p has also been confirmed to regulate autophagy in multiple studies ( 45 ). Similarly, we found that RUT induced the autophagy of BC cells by miR-149-3p.…”

Section: Discussionmentioning

confidence: 95%

Rutaecarpine prevents the malignant biological properties of breast cancer cells by the miR-149-3p/S100A4 axis

Xiong¹,

Xiong²,

Shan³

2022

Ann Transl Med

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Background Breast cancer (BC) is a frequent malignancy that endangers women’s health, and its fatality rate ranks 1st among female malignancies. Research has shown that rutaecarpine (RUT), which is a Chinese herbal medicine, blocks the proliferation of cancer cells by a variety of molecular mechanisms. However, the possible effects and mechanism of RUT in the autophagy and angiogenesis of BC cells has not been clearly articulated. Methods MiR-149-3p and S100A4 expression levels were assessed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and the optimal concentration and time of RUT was confirmed by Cell Counting Kit-8 (CCK-8) assays of the BC cells. After treatment, changes in cell proliferation and the cell cycle were evaluated by CCK-8 assays, clone formation assays, and flow cytometry, and the levels of apoptosis, autophagy, and angiogenesis-related proteins were identified by Western blot. The targeted regulation of miR-149-3p on S100A4 was also examined by luciferase reporter assays. Results We found that RUT inhibited cell growth and upregulated miR-149-3p in MDA-MB-231 cells. In relation to the biological function activity, RUT attenuated proliferation and angiogenesis, and induced cell-cycle arrest and autophagy by miR-149-3p in the MDA-MB-231 cells. Additionally, miR-149-3p downregulated S100A4 by targeting binding to S100A4, and S100A4 was required for miR-149-3p to play a role in BC progression. We also discovered that an autophagy agonist (rapamycin) or an angiogenesis inhibitor (TNP-470) changed BC progression mediated by the RUT/miR-149-3p/S100A4 axis. Conclusions RUT blocks the malignant behaviors of BC cells through the miR-149-3p/S100A4 axis and thus alters autophagy and angiogenesis. Thus, the RUT-mediated miR-149-3p/S100A4 axis might be an underlying therapeutic agent and target for BC.

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“…Interestingly, the pathway enrichment analysis in the present study also exhibited the role of bta-miR-149-5p in cancer. Previously, the roles of miR-149 in osteosarcoma [ 29 ], cancers of the digestive system [ 21 ], colorectal cancer [ 22 ], hepatocellular cancer [ 23 , 24 ], respiratory system cancer [ 25 ], breast cancer [ 26 ], and sebaceous gland carcinoma of the eyelid [ 27 ] have been well documented. Furthermore, in the present study, overexpression of bta-miR-149-5p significantly ( p < 0.05) upregulated LIPG ( endothelial lipase ) and KLF12 expression, which perform vital roles in cancer [ 91 , 92 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previously, our group exploited the negative regulatory role of miR-23a–miR27a–24-2 cluster in bovine adipocyte differentiation [ 19 ], and bta-miR-130a-b was found to affect bovine adipocyte differentiation by targeting PPARγ and CYP2UI [ 20 ]. Recently, studies have shown that miR-149 plays a pivotal role in the pathogenesis of various types of carcinomas including cancers of the digestive system [ 21 ], colorectal cancer [ 22 ], hepatocellular cancer [ 23 , 24 ], cancer of the respiratory system [ 25 ], breast cancer [ 26 ], and sebaceous gland carcinoma of the eyelid [ 27 ]. Therefore, this microRNA may be used as a potential diagnostic marker and therapeutic target against cancers.…”

Section: Introductionmentioning

confidence: 99%

RNA-Seq Reveals Function of Bta-miR-149-5p in the Regulation of Bovine Adipocyte Differentiation

Guo

Khan

Raza

et al. 2021

Animals

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Intramuscular fat is a real challenge for the experts of animal science to improve meat quality traits. Research on the mechanism of adipogenesis provides invaluable information for the improvement of meat quality traits. This study investigated the effect of bta-miR-149-5p and its underlying mechanism on lipid metabolism in bovine adipocytes. Bovine adipocytes were differentiated and transfected with bta-miR-149-5p mimics or its negative control (NC). A total of 115 DEGs including 72 upregulated and 43 downregulated genes were identified in bovine adipocytes. The unigenes and GO term biological processes were the most annotated unigene contributor parts at 80.08%, followed by cellular component at 13.4% and molecular function at 6.7%. The KEGG pathways regulated by the DEGs were PI3K-Akt signaling pathway, calcium signaling pathway, pathways in cancer, MAPK signaling pathway, lipid metabolism/metabolic pathway, PPAR signaling pathway, AMPK signaling pathway, TGF-beta signaling pathway, cAMP signaling pathway, cholesterol metabolism, Wnt signaling pathway, and FoxO signaling pathway. In addition to this, the most important reactome enrichment pathways were R−BTA−373813 receptor CXCR2 binding ligands CXCL1 to 7, R−BTA−373791 receptor CXCR1 binding CXCL6 and CXCL8 ligands, R−BTA−210991 basigin interactions, R−BTA−380108 chemokine receptors binding chemokines, R−BTA−445704 calcium binding caldesmon, and R−BTA−5669034 TNFs binding their physiological receptors. Furthermore, the expression trend of the DEGs in these pathways were also exploited. Moreover, the bta-miR-149-5p significantly (p < 0.01) downregulated the mRNA levels of adipogenic marker genes such as CCND2, KLF6, ACSL1, Cdk2, SCD, SIK2, and ZEB1 in bovine adipocytes. In conclusion, our results suggest that bta-miR-149-5p regulates lipid metabolism in bovine adipocytes. The results of this study provide a basis for studying the function and molecular mechanism of the bta-miR-149-5p in regulating bovine adipogenesis.

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MicroRNA-149: A review of its role in digestive system cancers

Cited by 10 publications

References 91 publications

Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment

Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment

Rutaecarpine prevents the malignant biological properties of breast cancer cells by the miR-149-3p/S100A4 axis

RNA-Seq Reveals Function of Bta-miR-149-5p in the Regulation of Bovine Adipocyte Differentiation

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