MicroRNA-149-3p expression correlates with outcomes of adrenocortical tumor patients and affects proliferation and cell cycle progression of H295A adrenocortical cancer cell line

Silva, Keteryne Rodrigues da; Veronez, Luciana Chain; Corrêa, Carolina Alves Pereira; Lira, Régia Caroline Peixoto; Baroni, Mirella; Queiroz, Rosane de Paula; Antonini, Sonir Roberto Rauber; Yunes, José Andrés; Brandalise, Sílvia Regina; Tone, Luíz Gonzaga; Scrideli, Carlos Alberto

doi:10.1007/s13577-022-00778-2

Cited by 3 publications

(2 citation statements)

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“…These are the potential therapeutic targets for the clinical treatment of cancer. MicroRNA‐149‐3p (miR‐149) is a recently discovered member of the MiR family 7 . In the human genome, miR‐149 is located on chromosome 11 in the q13.1 region.…”

Section: Introductionmentioning

confidence: 99%

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Harnessing tetrahedral framework nucleic acids for enhanced delivery of microRNA‐149‐3p: A new frontier in oral squamous cell carcinoma therapy

Xu,

Qin,

Liang

et al. 2024

Cell Proliferation

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Oral squamous cell carcinoma (OSCC), a type of malignant tumour that primarily occurs in the oral mucosa, has drawn considerable attention owing to its aggressive growth and potentially high metastatic rate. Surgical resection is the primary treatment method for OSCC and is typically combined with radiation therapy and chemotherapy. microRNA‐149‐3p (miR‐149) is a negative regulator of the Pi3k/Akt pathway and can effectively inhibit the proliferation of tumour cells. However, the application of miR‐149 is limited owing to its relatively low efficiency of cellular uptake and poor stability when used alone. To overcome these challenges, this study adopted a novel nucleic acid nanostructured material, tetrahedral framework nucleic acids (tFNAs). The use of tFNAs as carriers to assemble the T‐miR‐149 complex reduced the expression of Pi3k and Akt involved in tumorigenesis and alterations in proteins related to cell apoptosis. The results indicated that the bionic drug delivery system has an effective tumour suppressive effect on OSCC in mice, revealing its potential clinical value in the treatment of OSCC.

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Section: Introductionmentioning

confidence: 99%

“…MicroRNA‐149‐3p (miR‐149) is a recently discovered member of the MiR family. 7 In the human genome, miR‐149 is located on chromosome 11 in the q13.1 region. MiR‐149 is often considered a tumour suppressor, exhibiting inhibitory effects in cancers, such as oesophageal cancer and OSCC.…”

Section: Introductionmentioning

confidence: 99%