MicroRNA-148b enhances the radiosensitivity of B-cell lymphoma cells by targeting Bcl-w to promote apoptosis

Liu, Sihong; Wang, Peipei; Chen, Cunte; Li, Dan; Liu, Qiong-Yao; Lv, Lin; Liu, Xia; Wang, Lina; Li, Bao-Xiu; Weng, Chengyin; Fang, Xisheng; Cao, Xiaofei; Mao, Haibo; Chen, Xiaojun; Luo, Shao-Li; Zheng, Shu-Xiang; Liu, Guo-Long; Wu, Yong

doi:10.7150/ijbs.40756

Cited by 10 publications

(5 citation statements)

References 39 publications

(43 reference statements)

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“…There is growing interest in the molecular pathways of malignant transformation and progression of prostate cancer. Alterations in various oncogenes and tumor-suppressor genes can eventually lead to an imbalance between proliferation and programmed cell death, leading to net tumor growth and tumor progression ( 110 ). For instance, Bubendorf et al.…”

Section: The Role Of the Bcl-2 Family Proteins In Regulating Apoptosi...mentioning

confidence: 99%

The role of BCL-2 family proteins in regulating apoptosis and cancer therapy

et al. 2022

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Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies. Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their importance in regulating apoptosis, tumorigenesis, and cellular responses to anticancer therapy. Since the inflammatory response induced by apoptosis-induced cell death is very small, at present, the development of anticancer drugs targeting apoptosis has attracted more and more attention. Consequently, the focus of this review is to summarize the current research on the role of BCL-2 family proteins in regulating apoptosis and the development of drugs targeting BCL-2 anti-apoptotic proteins. Additionally, the mechanism of BCL-2 family proteins in regulating apoptosis was also explored. All the findings indicate the potential of BCL-2 family proteins in the therapy of cancer.

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Section: The Role Of the Bcl-2 Family Proteins In Regulating Apoptosi...mentioning

confidence: 99%

The role of BCL-2 family proteins in regulating apoptosis and cancer therapy

et al. 2022

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“…Furthermore, apoptosis-related genetic mutations or abnormal expression of apoptosis-related proteins may inhibit apoptosis and trigger tumorigenesis. Tumor treatment is vital in the induction of the expression of apoptosis-related genes to expedite tumor cell apoptosis [ 40 ]. In addition, a close connection may exist between apoptosis and autophagy.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of RELL2 as a Potential Biomarker Associated with Tumor Immune Infiltrating Cells in a Pan-Cancer Analysis

Musha

Ablikim³

et al. 2022

Disease Markers

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Background. Receptor expressed in lymphoid tissues-like 2 (RELL2), which is a member of RELT family, is closely associated with the plasma membrane and acts as a modulator for RELT signaling. Overexpression of RELL2 induces the activation of MAPK14/p38 cascade and apoptosis. However, whether RELL2 contributes to cancers remains unclear. Here, we examined its role in cancer patient prognosis and various tumors. Methods. We used several bioinformatics methods, specifically gene set enrichment analysis (GSEA), ScanNeo, and ESTIMATE, to analyze the CCLE dataset, GTEx dataset, and TCGA dataset. We investigated the possible association of RELL2 with the microsatellite instability (MSI) of various tumors, tumor mutational burden (TMB), immune checkpoint, immune neoantigens, immune microenvironment, and patient prognosis. Result. RELL2 is highly expressed in cancer compared with normal tissues. RELL2 expression is linked with worse progression-free interval and overall survival in numerous cancers. In most cancers, high RELL2 expression was related to a poor prognosis. RELL2 expression was significantly associated with the tumor microenvironment, MSI, and TMB. RELL2 expression is strongly associated with phenotypes that are of major clinical significance, particularly those associated with immune neoantigens and the expression profiles of immune checkpoint genes in pan-cancer. RELL2 expression strongly linked with the expressions of methyltransferases and DNA repair genes. It also significantly correlated with multiple signaling pathways through gene set enrichment analysis. Conclusion. RELL2 may be a prognostic biomarker in pan-cancer and may have an important function in tumorigenesis and progression.

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“…MicroRNAs were selected based on literature data [44][45][46]. MicroRNAs with expression levels exceeding 100 units were included in our study based on these data.…”

Section: Selection Of Mirnasmentioning

confidence: 99%

MicroRNA Expression Profile in Bone Marrow and Lymph Nodes in B-Cell Lymphomas

Veryaskina,

Titov,

Kovynev

et al. 2023

IJMS

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Hodgkin’s lymphomas (HL) and the majority of non-Hodgkin’s lymphomas (NHL) derive from different stages of B-cell differentiation. MicroRNA (miRNA) expression profiles change during lymphopoiesis. Thus, miRNA expression analysis can be used as a reliable diagnostic tool to differentiate tumors. In addition, the identification of miRNA’s role in lymphopoiesis impairment is an important fundamental task. The aim of this study was to analyze unique miRNA expression profiles in different types of B-cell lymphomas. We analyzed the expression levels of miRNA-18a, -20a, -96, -182, -183, -26b, -34a, -148b, -9, -150, -451a, -23b, -141, and -128 in lymph nodes (LNs) in the following cancer samples: HL (n = 41), diffuse large B-cell lymphoma (DLBCL) (n = 51), mantle cell lymphoma (MCL) (n = 15), follicular lymphoma (FL) (n = 12), and lymphadenopathy (LA) (n = 37), as well as bone marrow (BM) samples: HL (n = 11), DLBCL (n = 42), MCL (n = 14), FL (n = 16), and non-cancerous blood diseases (NCBD) (n = 43). The real-time RT-PCR method was used for analysis. An increase in BM expression levels of miRNA-26b, -150, and -141 in MCL (p < 0.01) and a decrease in BM levels of the miR-183-96-182 cluster and miRNA-451a in DLBCL (p < 0.01) were observed in comparison to NCBD. We also obtained data on increased LN levels of the miR-183-96-182 cluster in MCL (p < 0.01) and miRNA-18a, miRNA-96, and miRNA-9 in FL (p < 0.01), as well as decreased LN expression of miRNA-150 in DLBCL (p < 0.01), and miRNA-182, miRNA-150, and miRNA-128 in HL (p < 0.01). We showed that miRNA expression profile differs between BM and LNs depending on the type of B-cell lymphoma. This can be due to the effect of the tumor microenvironment.

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MicroRNA-148b enhances the radiosensitivity of B-cell lymphoma cells by targeting Bcl-w to promote apoptosis

Cited by 10 publications

References 39 publications

The role of BCL-2 family proteins in regulating apoptosis and cancer therapy

The role of BCL-2 family proteins in regulating apoptosis and cancer therapy

Comprehensive Analysis of RELL2 as a Potential Biomarker Associated with Tumor Immune Infiltrating Cells in a Pan-Cancer Analysis

MicroRNA Expression Profile in Bone Marrow and Lymph Nodes in B-Cell Lymphomas

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