MicroRNA‐148a‐3p inhibits cancer progression and is a novel screening biomarker for gastric cancer

Bao, Chenhui; Guo, Lin

doi:10.1002/jcla.23454

Cited by 19 publications

(16 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MiRNA expression profile is related to the characteristics of diverse cancers and can be used for screening differentially expressed miRNAs [22,23]. Through microarray analysis, we found that the expression of miR-4636, miR-1298, miR-4268, miR-4290, miR-1275, miR-148a-3p, miR-375, miR-943 and miR-665 were downregulated in GC tissues, which is consistent with the previous research findings [9,[24][25][26][27][28][29][30][31]. Herein, we mainly focused on miR-1269b.…”

Section: Discussionsupporting

confidence: 89%

MicroRNA-1269b inhibits gastric cancer development through regulating methyltransferase-like 3 (METTL3)

et al. 2021

View full text Add to dashboard Cite

The dysregulation of microRNAs (miRNAs) expression is relevant to the progression of many tumors. As reported, the abnormal expression of miR-1269b is pivotal in certain cancers' progression. This work was designed to study the role and hidden mechanism of miR-1269b in gastric cancer (GC) progression. In this work, we proved that miR-1269b was lowly expressed in GC tissues and cell lines, which was associated with larger tumor size and lymph node metastasis. MiR-1269b overexpression repressed the multiplication, migration and invasion of GC cells while miR-1269b inhibition had the opposite effects. Methyltransferase-like 3 (METTL3) was identified as the direct target of miR-1269b in GC cells, and its overexpression reversed the inhibitory effect of transfection of miR-1269b mimics on GC cell viability, migration and invasion. On all accounts, these data indicated that miR-1269b inhibits GC progression via targeting METTL3.

show abstract

Section: Discussionsupporting

confidence: 89%

MicroRNA-1269b inhibits gastric cancer development through regulating methyltransferase-like 3 (METTL3)

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The proliferation of bone marrow mesenchymal stem cell and non-smallcell lung cancer can also be promoted by miR-148a-3p mimic [41,42] which consistent with our present research. However, Bao et al and Wang et al have reported that overexpression of miR-148a-3p inhibited the proliferation of gastric cancer cells [43] and diabetic retinopathy cell model [44], respectively. Therefore, miR-148a-3p displays inconsistent effects in the proliferation of different cell types.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA Profiling Reveals an Abundant ssc-miRNA-148a-3p that Promotes Proliferation and Differentiation during Intramuscular Adipogenesis in Chinese Guizhou Congjiang Pigs Breeds by targeting PPARGC1A

Tan

Chen

Teng

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundIntramuscular fat development is regulated by a series of complicated processes, and non-coding RNA (ncRNA) such as microRNA (miRNA) plays a critical role during intramuscular preadipocyte proliferation and differentiation development in pigs. In present research, we detected the expression profiles of miRNA during different differentiation stages, namely, day 0 (D0), day 4 (D4), and day 8 (D8), of intramuscular preadipocytes from the longissimus dorsi muscle of Chinese Guizhou Congjiang pigs to provide first insights into their potential involvement in intramuscular preadipocyte development. And we investigated the function of miR-148a-3p in adipocyte proliferation, apoptosis, and differentiation. ResultsA total of 67, 95, and 16 differentially expressed (DE) miRNAs were detected between D4 and D0, between D8 and D0, and between D8 and D4, respectively. We further characterized the role of miR-148a-3p which was differentially expressed and highest expressed abundance in D0, D4, and D8. To explore the role of miR-148a-3p in porcine intramuscular preadipocyte, miR-148a-3p mimics and inhibitors were used to perform miR-148a-3p overexpression and knockdown, respectively. Overexpression of miRNA-148a-3p increased the number of intramuscular preadipocytes in the S/G2 phase of the cell cycle and decreased the proportion of cells in the G0/G1 phase. Moreover, it promoted proliferation by regulation of cyclin B, cyclin G1, cyclin D1, CDK2, CDK3, and CDK4 and inhibited apoptosis of intramuscular preadipocyte by regulating the expression of Caspase-3, Bax, and Bcl-2. Meanwhile, the mimics of miR-148a-3p dramatically promoted intramuscular preadipocyte differentiation and upregulated the expression levels of adipogenic marker genes PPARγ, FASN, FABP4, HSL, APOE, LPL, and CEBPα. Furthermore, miR-148a-3p promoted intramuscular preadipocyte differentiation via restraining the AMPK/ACC/CPT1C signaling pathway. PPARGC1A was identified as a target gene of miR-148a-3p by luciferase activity and western blotting assays. ConclusionOur study provides novel insights into the regulatory mechanisms underlying intramuscular preadipocyte development and identified amount of miRNAs whose regulatory potential will need to be explored in the future. Our results establish that miR-148a-3p promoted adipocyte differentiation by targeting PPARGC1A.

show abstract

“…Recently, studies have also explored the role of miRNAs in GCs including miR‐148a‐3p 40 and miR‐212. 41 Bao et al investigated the diagnostic potential and biological function of miR‐148a‐3p in GC progression in the GC tissues and plasma of patients and found that miR‐148a‐3p was significantly downregulated in both the gastric tissue and plasma of GC patients, suggesting that miR‐148a‐3p may inhibit cancer progression and is a novel diagnostic biomarker for GC.…”

Section: Discussionmentioning

confidence: 99%

“… 41 Bao et al investigated the diagnostic potential and biological function of miR‐148a‐3p in GC progression in the GC tissues and plasma of patients and found that miR‐148a‐3p was significantly downregulated in both the gastric tissue and plasma of GC patients, suggesting that miR‐148a‐3p may inhibit cancer progression and is a novel diagnostic biomarker for GC. 40 Shao et al 41 analyzed the relationship of serum level of miR‐212 with GC through detecting the serum level of miR‐212 in 100 healthy people and 110 GC patients, and these authors found that miR‐212 was epigenetically downregulated in GC and could directly regulate the 3′UTR of SOX4 mRNA to suppress p53 and Bax, suggesting that low level of miR‐212 can be a potential circulation biomarker and poor prognosis predicator of GC. Novel findings in our study and in other studies 40 , 41 will ultimately accumulate to clarify the mechanism of GC and clear the way for better treatment of this cancer.…”

Section: Discussionmentioning

confidence: 99%

miR‐125a‐5p promotes gastric cancer growth and invasion by regulating the Hippo pathway

Wang

et al. 2021

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

MicroRNA‐148a‐3p inhibits cancer progression and is a novel screening biomarker for gastric cancer

Cited by 19 publications

References 24 publications

MicroRNA-1269b inhibits gastric cancer development through regulating methyltransferase-like 3 (METTL3)

MicroRNA-1269b inhibits gastric cancer development through regulating methyltransferase-like 3 (METTL3)

MicroRNA Profiling Reveals an Abundant ssc-miRNA-148a-3p that Promotes Proliferation and Differentiation during Intramuscular Adipogenesis in Chinese Guizhou Congjiang Pigs Breeds by targeting PPARGC1A

miR‐125a‐5p promotes gastric cancer growth and invasion by regulating the Hippo pathway

Contact Info

Product

Resources

About