MicroRNA 146a Expression in Rheumatoid Arthritis: Association with Tumor Necrosis Factor–Alpha and Disease Activity

Abou-Zeid, Abla A.; Saad, Mowaffak; Soliman, Eiman

doi:10.1089/gtmb.2011.0026

Cited by 73 publications

(64 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…summarises all of these reports to date. A recent report by Abou-Zeid et al 30 has basically completely reproduced our 2008 work demonstrating the elevated level of miR-146a in PBMC of 70 RA patients compared to 60 controls. Their data show that miR-146a expression is significantly higher in patients with RA than in those with osteoarthritis (n=45) and in controls (p<0.0001) 30.…”

Section: Aberrant Expression Of Mir-146a In Rasupporting

confidence: 83%

“…A recent report by Abou-Zeid et al 30 has basically completely reproduced our 2008 work demonstrating the elevated level of miR-146a in PBMC of 70 RA patients compared to 60 controls. Their data show that miR-146a expression is significantly higher in patients with RA than in those with osteoarthritis (n=45) and in controls (p<0.0001) 30. In patients with RA, miR-146a positively correlates with tumour necrosis factor (TNF) α (p=0.0003) and disease activity monitored by the erythrocyte sedimentation rate (p=0.022) and the disease activity score in 28 joints (p=0.009) 30…”

Section: Aberrant Expression Of Mir-146a In Rasupporting

confidence: 83%

See 1 more Smart Citation

MicroRNA-146a in autoimmunity and innate immune responses

2012

View full text Add to dashboard Cite

MicroRNA (miRNA) are approximately 22 nucleotide single-stranded RNA that regulate the stability of target messenger RNA by selective binding to specific sites at the 3'-untranslated regions (UTR). This triggers repression in translation and mRNA degradation. It has been estimated that approximately 60% of all mRNA are under the control of miRNA. Among the known hundreds of miRNA, some are considered master regulators controlling either a single or multiple cellular pathways. Some miRNA are known to affect development and cell differentiation, while others are implicated in immunity and autoimmune diseases. A very interesting example is miR-146a, which has been reported to be downregulated in systemic lupus erythematosus and upregulated in rheumatoid arthritis (RA). Several groups have recently focused their attention on miRNA in the pathogenesis of RA. Interestingly, the expression of miR-146a is upregulated in different cell types and tissues in RA patients. miRNA in RA could also be considered as possible future targets for new therapeutic approaches. This discussion will focus on the current understanding in the function of miR-146a in endotoxin tolerance and cross-tolerance, and how it may contribute to modulate the overproduction of known pathogenic cytokines, such as tumour necrosis factor α.

show abstract

Section: Aberrant Expression Of Mir-146a In Rasupporting

confidence: 83%

Section: Aberrant Expression Of Mir-146a In Rasupporting

confidence: 83%

MicroRNA-146a in autoimmunity and innate immune responses

2012

View full text Add to dashboard Cite

show abstract

“…RA is a complex disease involving the interplay among multiple mediators and pathways of inflammation and bone damage. The expression of these mediators and their interactions in turn are controlled by a variety of regulators, including micro-RNAs (miRNAs) [5,6,7]. While current therapies offer a diverse choice of drugs for RA patients, only 50–60% of these patients respond to them [3,8].…”

Section: Introductionmentioning

confidence: 99%

“…In RA, miR-146a and miR-155 are among the most studied miRNAs [27]. It has been reported that miR-146a is increased in RA in serum, peripheral blood, CD4 + T cells, and synovial tissue [5,27,28,29]. However, a reduction in miR-146a in RA fibroblast-like synoviocytes (FLS) has also been reported, implicating this miRNA in anti-inflammatory effects on FLS [6].…”

Section: Introductionmentioning

confidence: 99%

The Micro-RNA Expression Profiles of Autoimmune Arthritis Reveal Novel Biomarkers of the Disease and Therapeutic Response

Dudics

Venkatesha

Moudgil

2018

IJMS

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic autoimmune disease of the joints affecting about 0.3–1% of the population in different countries. About 50–60 percent of RA patients respond to presently used drugs. Moreover, the current biomarkers for RA have inherent limitations. Consequently, there is a need for additional, new biomarkers for monitoring disease activity and responsiveness to therapy of RA patients. We examined the micro-RNA (miRNA) profile of immune (lymphoid) cells of arthritic Lewis rats and arthritic rats treated with celastrol, a natural triterpenoid. Experimental and bioinformatics analyses revealed 8 miRNAs (miR-22, miR-27a, miR-96, miR-142, miR-223, miR-296, miR-298, and miR-451) and their target genes in functional pathways important for RA pathogenesis. Interestingly, 6 of them (miR-22, miR-27a, miR-96, miR-142, miR-223, and miR-296) were further modulated by celastrol treatment. Interestingly, serum levels of miR-142, miR-155, and miR-223 were higher in arthritic versus control rats, whereas miR-212 showed increased expression in celastrol-treated rats compared with arthritic rats or control rats. This is the first study on comprehensive miRNA expression profiling in the adjuvant-induced arthritis (AA) model and it also has revealed new miRNA targets for celastrol in arthritis. We suggest that subsets of the above miRNAs may serve as novel biomarkers of disease activity and therapeutic response in arthritis.

show abstract

“…miR-146a is a relatively well known miRNA in inflammatory autoimmune diseases [14, 15]. Studies have indicated that miR-146a plays an important role in the pathogenesis of several autoimmune disorders, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis [16-18]. miR-146a was also proven to be associated with the development of autoimmune thyroid diseases [19, 20].…”

Section: Introductionmentioning

confidence: 99%

Circulating MiR-146a May be a Potential Biomarker of Coronary Heart Disease in Patients with Subclinical Hypothyroidism

Xiaohui

Zhang

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Subclinical hypothyroidism (SCH) plays a crucial role in the development and progression of coronary heart disease (CHD). However, any associated changes in the circulating microRNAs (miRNAs) levels and slightly elevated thyroid stimulating hormone (TSH) levels in CHD patients are unknown. miR-146a is a well known miRNA associated with inflammatory autoimmune diseases. Here, we evaluated miR-146a expression in patients, with the goal of re-evaluating the effect of SCH on CHD. Methods: A total of 192 study subjects who underwent coronary angiography for either suspected or confirmed CHD were enrolled in 3 groups: CHD with SCH, CHD alone, and healthy controls. The circulating levels of miR-146a were quantified using qRT-PCR. Results: Levels of miR-146a were positively correlated with CHD severity, as indicated by the Gensini score (r=0.354). The relative expression of miR-146a in the CHD+SCH, CHD and healthy control groups was 2.223±0.827, 1.588±0.726 and 0.632±0.309, respectively. Plasma TSH levels were positively correlated with miR-146a levels (r=0.321). According to multivariate logistic regression analyses, miR-146a levels were associated with the incidence of CHD in patients with SCH. For diagnosing CHD, the area under the ROC curve (AUC) of miR-146a and TSH was 0.779 and 0.752, respectively. When the TSH and miR-146a levels were combined to form a composite panel, the AUC of the panel was 0.858. Conclusion: Plasma miR-146a levels correlated with the severity of coronary atherosclerosis and increased with TSH slightly elevated in patients with CHD. Thus, miR-146a may have good predictive value for CHD among individuals with elevated TSH levels.

show abstract

MicroRNA 146a Expression in Rheumatoid Arthritis: Association with Tumor Necrosis Factor–Alpha and Disease Activity

Abstract: miRNA 146a expression is upregulated in patients with RA and may be a potentially useful marker of disease activity in these patients. Lack of overexpression of miRNA 146a in the presence of increased TNF-α in OA requires further investigation.

Cited by 73 publications

References 28 publications

MicroRNA-146a in autoimmunity and innate immune responses

MicroRNA-146a in autoimmunity and innate immune responses

The Micro-RNA Expression Profiles of Autoimmune Arthritis Reveal Novel Biomarkers of the Disease and Therapeutic Response

Circulating MiR-146a May be a Potential Biomarker of Coronary Heart Disease in Patients with Subclinical Hypothyroidism

Contact Info

Product

Resources

About