MicroRNA-145 plays a role in mitochondrial dysfunction in alveolar epithelial cells in lipopolysaccharide-induced acute respiratory distress syndrome

Han, Yong; Mu, Sucheng; Wang, Jianli; Wei, Wei; Zhu, Ming; Du, Shangming; Min, Min; Xu, Yunjie; Song, Zifang; Tong, Chaoyang

doi:10.5847/wjem.j.1920-8642.2021.01.009

Cited by 2 publications

(2 citation statements)

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“…The copyright holder for this this version posted November 5, 2021. ; https://doi.org/10.1101/2021.11.04.467383 doi: bioRxiv preprint epithelial cells. As an important miRNA, miR-145 can be regulated by salidroside in a concentration-dependent manner in osteoarthritis injury model [15]. However, the role of salidroside and miR-145 in ALI/ARDS remains not fully investigated.…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that miRNAs act as key regulators to control the process of inflammation, metabolism and repair in alveolar epithelial cells. As an important miRNA, miR-145 can be regulated by salidroside in a concentration-dependent manner in osteoarthritis injury model [15]. However, the role of salidroside and miR-145 in ALI/ARDS remains not fully investigated.…”

Section: Introductionmentioning

confidence: 99%

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Salidroside protects lipopolysaccharide-induced acute lung injury by regulating miR-145/ cytosolic phospholipase A₂

Shi

2021

Preprint

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Salidroside is one of the main active components from the root of Rhodiola rosea. Previous reports showed that salidroside exhibits anti-inflammatory properties, but the underlying mechanisms are not fully understood. Here, we observed the effects of salidroside on lipopolysaccharide (LPS)-induced acute lung injury (ALI) both in vivo and in vitro. As revealed by survival study, salidroside reduced mortality of rats and prolonged their survival time. Meanwhile, salidroside significantly improved LPS-induced lung histopathologic changes, decreased lung wet-to-dry and lung-to-body weight ratios, inhibited lung myeloperoxidase (MPO) activity. Salidroside also suppressed the expression of cytosolic PLA2 (cPLA2), the activity of phospholipase A2 (PLA2) in LPS-treated rats and the metabolites of PLA2 in bronchoalveolar lavage fluid (BALF), which was confirmed by results of prostaglandin E2 (PGE2), leukotriene B4 (LTB4) and thromboxane B2 (TXB2) detection. And the expression of microRNA-145 in LPS-treated rats was up-regulated by salidroside. Besides, salidroside raised the level of miR-145and reduced PLA2 activity in LPS-induced A549 cells in a concentration-dependent manner, which was obviously reversed by miR-145 inhibition. In conclusion, the current study demonstrated that salidroside exhibited a protective effect on LPS-induced ALI by inhibiting of the inflammatory response, which may involve in the up-regulation of miR-145 and the suppression of cPLA2.HighlightsSalidroside reduces acute lung injury by inhibiting the increment and metabolism of phospholipase A2;Salidroside inhibits LPS-induced PLA2 increase dependent on miR-145;The inhibitory effect of Salidroside on Phospholipases A2 provides a link between the identification of new targets and potential new therapeutic agents for the treatment of acute lung injury.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Salidroside protects lipopolysaccharide-induced acute lung injury by regulating miR-145/ cytosolic phospholipase A₂

Shi

2021

Preprint

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Patient care during interfacility transport: a narrative review of managing diverse disease states

Tran¹,

O’Connell²,

Hakopian³

et al. 2023

World Journal of Emergency Medicine

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BACKGROUND: When critically ill patients require specialized treatment that exceeds the capability of the index hospitals, patients are frequently transferred to a tertiary or quaternary hospital for a higher level of care. Therefore, appropriate and effi cient care for patients during the process of transport between two hospitals (interfacility transfer) is an essential part of patient care. While medical adverse events may occur during the interfacility transfer process, there have not been evidence-based guidelines regarding the equipment or the practice for patient care during transport. METHODS:We conducted searches from the PubMed, Cumulative Index of Nursing and Allied Health (CINAHL), and Scopus databases up to June 2022. Two reviewers independently screened the titles and abstracts for eligibility. Studies that were not in the English language and did not involve critically ill patients were excluded. RESULTS:The search identified 75 articles, and we included 48 studies for our narrative review. Most studies were observational studies. CONCLUSION:The review provided the current evidence-based management of diverse disease states during the interfacility transfer process, such as proning positioning for respiratory failure, extracorporeal membrane oxygenation (ECMO), obstetric emergencies, and hypertensive emergencies (aortic dissection and spontaneous intracranial hemorrhage).

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MicroRNA-145 plays a role in mitochondrial dysfunction in alveolar epithelial cells in lipopolysaccharide-induced acute respiratory distress syndrome

Cited by 2 publications

References 33 publications

Salidroside protects lipopolysaccharide-induced acute lung injury by regulating miR-145/ cytosolic phospholipase A₂

Salidroside protects lipopolysaccharide-induced acute lung injury by regulating miR-145/ cytosolic phospholipase A₂

Patient care during interfacility transport: a narrative review of managing diverse disease states

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MicroRNA-145 plays a role in mitochondrial dysfunction in alveolar epithelial cells in lipopolysaccharide-induced acute respiratory distress syndrome

Cited by 2 publications

References 33 publications

Salidroside protects lipopolysaccharide-induced acute lung injury by regulating miR-145/ cytosolic phospholipase A2

Salidroside protects lipopolysaccharide-induced acute lung injury by regulating miR-145/ cytosolic phospholipase A2

Patient care during interfacility transport: a narrative review of managing diverse disease states

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Salidroside protects lipopolysaccharide-induced acute lung injury by regulating miR-145/ cytosolic phospholipase A₂

Salidroside protects lipopolysaccharide-induced acute lung injury by regulating miR-145/ cytosolic phospholipase A₂