MicroRNA‑145 inhibits migration and induces apoptosis in human non‑small cell lung cancer cells through regulation of the EGFR/PI3K/AKT signaling pathway

Li, Bin; Ding, Cuimin; Li, Yan‐Xiao; Peng, Jingcui; Geng, Ning; Qin, Wen‐Wen

doi:10.3892/or.2018.6666

Cited by 21 publications

(22 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, mammalian rapamycin (mTOR) is an important target downstream of Akt that can be activated by phosphorylation of Akt. It can control the translation of specific mRNAs, regulate protein synthesis and affect cell proliferation (Kim et al, 2001;Autret et al, 2008;Daxing et al, 2009;Shi et al, 2013;Li et al, 2018;Noorolyai et al, 2019). In the early stage of EV infection, the mitogen-activated protein kinase (MAPK)/ERK signaling pathway can be activated together with the PI3K/AKT pathway; this phenomenon has been observed in a variety of susceptible cells (Wong et al, 2005;Xie et al, 2016).…”

Section: Pi3k/akt Pathway and Apoptosis Inhibitionmentioning

confidence: 99%

Regulation of Apoptosis by Enteroviruses

et al. 2020

View full text Add to dashboard Cite

Enterovirus infection can cause a variety of diseases and severely impair the health of humans, animals, poultry, and other organisms. To resist viral infection, host organisms clear infected cells and viruses via apoptosis. However, throughout their long-term competition with host cells, enteroviruses have evolved a series of mechanisms to regulate the balance of apoptosis in order to replicate and proliferate. In the early stage of infection, enteroviruses mainly inhibit apoptosis by regulating the PI3K/ Akt pathway and the autophagy pathway and by impairing cell sensors, thereby delaying viral replication. In the late stage of infection, enteroviruses mainly regulate apoptotic pathways and the host translation process via various viral proteins, ultimately inducing apoptosis. This paper discusses the means by which these two phenomena are balanced in enteroviruses to produce virus-favoring conditions-in a temporal sequence or through competition with each other. This information is important for further elucidation of the relevant mechanisms of acute infection by enteroviruses and other members of the picornavirus family.

show abstract

Section: Pi3k/akt Pathway and Apoptosis Inhibitionmentioning

confidence: 99%

Regulation of Apoptosis by Enteroviruses

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The ten miRNAs explored in the present study have been evaluated as lung cancer markers in other studies. Potential mechanisms of the miRNAs on lung cancer were explored in previous study (Seen in Table 7), the main signaling pathways including PI3K/Akt/NF-Κb (miR-21, miR-223, miR-145, miR-126, and miR-30a) [24][25][26][27][28] , STAT3 (miR-126, and miR-197) [27,29,30] , estrogen (miR-21 and miR-210) [31] , et al Table 7. Potential mechanisms of the miRNAs on lung cancer miRNAs Pathways miR-20a angiogenesis, TGF-β pathway, platelet-derived growth factor pathway, and oxidative stress response [32] miR-21 PI3K/AKT/NF-κB signaling pathway, and estrogen signaling pathway [24] ; autophagy-related AMPK/ULK1 signaling pathway [56] miR-210 estrogen signaling pathway [31] miR-223 Notch/miR-223/FBXW7 pathway [57] ; NF-κB signaling pathway [58] ;…”

Section: Discussionmentioning

confidence: 99%

“…IGF-1R/Akt/S6 signaling pathway [25] ; IGF-1R/PI3K/AKT signaling pathway [59] miR-25 ERK signaling pathway [60] ; cell cycle regulation [61] miR-145 ERβ/MALAT1/miR145-5p/NEDD9 signaling pathway [62] ; EGFR/PI3K/AKT signaling pathway [26] ; JNK signaling pathway [63] ; mTOR signaling pathway [64] miR-126 STAT3 signal pathway [30] ; PI3K/AKT/Snail signal pathway [27] miR-30a PI3K/AKT signaling pathway [28] miR-197 miR-197/CKS1B/STAT3-mediated PD-L1 network [29] Transcription factors such as HMBOX1, DDX5, and ZBTB5, which were identified to be co-regulated by miR-20a and miR-15b, have implication on cancer progression [32] . E2F1 and E2F8 belong to E2F transcription factor family that is essential for the regulation of cell cycle progression [33] .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Plasma MicroRNAs for Lung Cancer Using Support Vector Machine Model

Wang¹,

Ding²,

Duan³

et al. 2019

J. Cancer

View full text Add to dashboard Cite

Aim: Small single-stranded non-coding RNAs (miRNAs) play an important role in carcinogenesis through degrading target mRNAs. However, the diagnostic value of miRNAs was not explored in lung cancers. In this study, a support-vector-machine (SVM) model for diagnosis of lung cancer was established based on plasma miRNAs biomarkers, clinical symptoms and epidemiology material. Methods: The expressions of plasma miRNA were examined with SYBR Green-based quantitative real-time PCR. Results: We identified that the expressions of 10 plasma miRNAs (miR-21, miR-20a, miR-210, miR-145, miR-126, miR-223, miR-197, miR-30a, miR-30d, miR-25), smoking status, fever, cough, chest pain or tightness, bloody phlegm, haemoptysis, were significantly different between lung cancer and control groups (P<0.05). The accuracies of the combined SVM, miRNAs SVM, symptom SVM, combined Fisher, miRNAs Fisher and symptom Fisher were 96.34%, 80.49%, 84.15%, 84.15%, 75.61%, and 80.49%, respectively; AUC of these six model were 0.976, 0.841, 0.838, 0.865, 0.750, and 0.801, respectively. The accuracy and AUC of combined SVM were higher than the other 5 models (P<0.05). Conclusions: Our findings indicate that SVM model based on plasma miRNAs biomarkers may serve as a novel, accurate, noninvasive method for auxiliary diagnosis of lung cancer.

show abstract

“…) . However, the expression of miR‐145 increased in the sputa of patients with asthma, inducing the opposite response in tissues …”

Section: Bronchial Asthma and Mirnamentioning

confidence: 99%

Molecular techniques for respiratory diseases: MicroRNA and extracellular vesicles

et al. 2019

View full text Add to dashboard Cite

miRNA are a class of evolutionarily conserved non-coding 19-to 22-nt regulatory RNA. They affect various cellular functions through modulating the transcriptional and post-transcriptional levels of their target mRNA by changing the stability of protein-coding transcripts or attenuating protein translation. miRNA were discovered in the early 1990s, and they have been the focus of new research in both basic and clinical medical sciences. Today, it has become clear that specific miRNA are linked to the pathogenesis of respiratory diseases, as well as cancer and cardiovascular disease. In addition, EV, including exosomes, which are small membrane-bound vesicles secreted by cells, were found to contain various functional miRNA that can be used for diagnostic and therapeutic purposes. As body fluids, such as blood and respiratory secretions, are major miRNA sources in the body, EV carrying extracellular miRNA are considered potentially useful for the diagnosis and assessment of pathological conditions, as well as the treatment of respiratory or other diseases. Although research in the field of lung cancer is actively progressing, studies in other respiratory fields have emerged recently as well. In this review, we provide an update in the topics of miRNA and EV focused on airway inflammatory diseases, such as asthma and COPD, and explore their potential for clinical applications on respiratory diseases.

show abstract

MicroRNA‑145 inhibits migration and induces apoptosis in human non‑small cell lung cancer cells through regulation of the EGFR/PI3K/AKT signaling pathway

Cited by 21 publications

References 29 publications

Regulation of Apoptosis by Enteroviruses

Regulation of Apoptosis by Enteroviruses

Diagnostic Value of Plasma MicroRNAs for Lung Cancer Using Support Vector Machine Model

Molecular techniques for respiratory diseases: MicroRNA and extracellular vesicles

Contact Info

Product

Resources

About