MicroRNA-145 influences the balance of Th1/Th2 via regulating RUNX3 in asthma patients

Fan, Linxia; Wang, Xiaojun; Fan, Lei; Chen, Qizhang; Zhang, Hong; Hui, Pei; Xu, Aixia; Wang, Hongjuan; Yu, Yang

doi:10.1080/01902148.2016.1256452

Cited by 32 publications

(30 citation statements)

References 15 publications

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“…Runx3 can shift cellular differentiation towards Th1 cells with positive feedback on the T‐bet pathway and weakening the GATA3 pathway. As a result, due to significant effects on Runx3, miR‐145 can be a diagnostic and therapeutic marker (Fan et al, ).…”

Section: Micrornas: Their Functions In Asthmamentioning

confidence: 99%

Involvement of microRNAs in physiological and pathological processes in asthma

Mousavi

Ahmadi

Jamalkandi

et al. 2019

Journal Cellular Physiology

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Asthma is the most common respiratory disease accompanied by lung inflammatory disorders. The main symptoms are airway obstruction, chronic inflammation due to mast cell and eosinophil activity, and the disturbance of immune responses mostly mediated by the Th2 response. Genetic background and environmental factors also contribute to the pathogenesis of asthma. Today, microRNAs (miRNAs) are known as remarkable regulators of gene expression. As a small group of noncoding singlestrand RNAs, mature miRNAs (~21 nucleotides) modulate the gene expression by targeting complement RNAs at both transcriptional and posttranscriptional levels.The role of miRNAs in the pathogenesis of many diseases such as allergies, asthma, and autoimmunity has been vastly studied. This review provides a thorough research update on the role of miRNAs in the pathogenesis of asthma and their probable role as diagnostic and/or therapeutic biomarkers.

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Section: Micrornas: Their Functions In Asthmamentioning

confidence: 99%

Involvement of microRNAs in physiological and pathological processes in asthma

Mousavi

Ahmadi

Jamalkandi

et al. 2019

Journal Cellular Physiology

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“…Reduced RUNX3 in gastric carcinoma is positively correlated with repressed Th1-associated factor and decreased Th1 cell-mediated immunity is associated with immune escape of cancer cells ( 52 , 53 ). In addition, miRNA-145 could regulate the balance of Th1/Th2 through targeting RUNX3 in asthma patients, and miRNA-145 and RUNX3 can be used as biomarkers or targets in the diagnosis or therapy of asthma ( 95 ). On this note, it can be of great significance to target RUNX3 for the prevention of immunological disease, including the immune escape of cancer cells.…”

Section: Implications For Cancer Therapymentioning

confidence: 99%

Emerging role of RUNX3 in the regulation of tumor microenvironment

Manandhar

Lee

2018

BMB Rep.

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A number of genes have been therapeutically targeted to relieve cancer, but cancer relapse is still a growing issue. The concept that the surrounding tumor environment is critical for the progression of cancer may foster an answer to the issue of cancer malignancy. Runt domain transcription factors (RUNX1, 2, and 3) are evolutionarily conserved and have been intensively studied for their roles in normal development and pathological conditions. During tumor growth, a hypoxic microenvironment and infiltration of the tumor by immune cells are common phenomena. In this review, we briefly introduce the consequences of hypoxia and immune cell infiltration into the tumor microenvironment with a focus on RUNX3 as a critical regulator. Furthermore, based on our current knowledge of the functional role of RUNX3 in hypoxia and immune cell maintenance, a probable therapeutic intervention is suggested for the effective management of tumor growth and malignancy.

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“…More recently, the crucial role of miRNA has been implicated in various immunological and inflammatory disorders. Emerging evidences also have revealed the specific miRNA profiles in the development of bronchial asthma, such as miR-16, miR-21, miR-126, miR-145 et al [15][16][17][18]. Recently, miR-223 has been reported to emerge as critical regulators of the response to bacterial stimulation and the immune system [19,20].…”

Section: Introductionmentioning

confidence: 99%

MiR-223 plays a protecting role in neutrophilic asthmatic mice through the inhibition of NLRP3 inflammasome

Wang

et al. 2020

Respir Res

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Background: Neutrophilic subtype asthma occurs in approximately 15-25% of the asthma cases and is associated with severe airflow obstruction, corticosteroid resistance. MicroRNA plays a vital role in regulating many immune processes, but how miRNA circuits coordinate airway inflammation during neutrophilic asthma is unclear. Methods: To investigate the molecular mechanism of miR-223 in regulation of neutrophilic airway inflammation, miR-223 knockout mice were used to the OVA/CFA-induced neutrophilic asthma or treated with NLRP3 inhibitor and IL-1β receptor antagonist. Based on the results obtained, wide-type mice were subsequently treated with miR-223 agomirs or negative control agomirs, and the effects on airway inflammation were assessed using morphometric techniques, quantitative RT-PCR, western blot, ELISA and other molecular approaches. Results: The expression of miR-223 was upregulated in lung tissues of experimental mice model. Furthermore, miR-223 −/− mice led to aggravated neutrophilic airway inflammation with heightened histopathological, inflammatory cells and cytokines readouts. Moreover, miR-223 −/− mice also presented with enhanced NLRP3 inflammasome level with elevated IL-1β. Blocking NLRP3 or IL-1β diminished this phenotype. Finally, overexpression of miR-223 via treatment with miR-223 agomirs attenuated airway inflammation, NLRP3 levels and IL-1β release. Conclusions: The findings of this study revealed a crucial role for miR-223 in regulating the immunoinflammatory responses by depressing the NLRP3/ IL-1β axis in neutrophilic asthma.

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MicroRNA-145 influences the balance of Th1/Th2 via regulating RUNX3 in asthma patients

Abstract: MicroRNA-145 could regulate the balance of Th1/Th2 through targeting the RUNX3 in asthma patients. MicroRNA-145 and RUNX3 may be used as biomarkers or targets in the diagnosis or therapy of asthma.

Cited by 32 publications

References 15 publications

Involvement of microRNAs in physiological and pathological processes in asthma

Involvement of microRNAs in physiological and pathological processes in asthma

Emerging role of RUNX3 in the regulation of tumor microenvironment

MiR-223 plays a protecting role in neutrophilic asthmatic mice through the inhibition of NLRP3 inflammasome

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