MicroRNA-144 affects radiotherapy sensitivity by promoting proliferation, migration and invasion of breast cancer cells

Yu, Lei; Yang, Yanming; Hou, Jiguang; Zhai, Chengwei; Song, Yunhao; Zhang, Zhiliang; Qiu, Ling; Jia, Xiaojing

doi:10.3892/or.2015.4173

Cited by 53 publications

(48 citation statements)

References 37 publications

(29 reference statements)

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“…MiR-144 has been reported to affect sensitivity in radiotherapy by promoting proliferation, migration and invasion of breast cancer cells37. Dysregulation of miR-144 has been described in studies of multiple cancers38394041.…”

Section: Discussionmentioning

confidence: 99%

Changes in miRNA in the lung and whole blood after whole thorax irradiation in rats

Gao

Liu

Narayanan

et al. 2017

Sci Rep

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We used a rat model of whole thorax x-ray irradiation to profile the microRNA (miRNA) in lung and blood up to 4 weeks after radiation. MiRNA from normal and irradiated Wistar rat lungs and whole blood were analyzed by next-generation sequencing and the changes by radiation were identified by differential deRNA-seq 1, 2, 3 and 4 weeks after irradiation. The average total reads/library was 2,703,137 with a mean of 88% mapping to the rat genome. Detailed profiles of 100 of the most abundant miRNA in rat blood and lung are described. We identified upregulation of 4 miRNA, miR-144-5p, miR-144-3p, miR-142-5p and miR-19a-3p in rat blood 2 weeks after radiation that have not previously been shown to be altered after radiation to the lung. Ingenuity Pathway Analysis identified signaling of inflammatory response pathways. These findings will support development of early detection methods, as well as mechanism(s) of injury and mitigation in patients after radiotherapy or radiological accidents.

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Section: Discussionmentioning

confidence: 99%

Changes in miRNA in the lung and whole blood after whole thorax irradiation in rats

Gao

Liu

Narayanan

et al. 2017

Sci Rep

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“…The overexpression of miR-144 increased the proliferation rate of tumor cells in the MDA-MB-231 cell line. Additionally, the migration and invasion of tumor cell lines of MDA-MB-231 and SKBR3 were increased by elevated miR-144 expression [148]. Kahraman M et al showed the overexpression of hsa-miR-144-3p and hsa-miR-144-5p in the aggressive subtype triple-negative breast cancer (TNBC).…”

Section: Mir-144 In Breast Cancermentioning

confidence: 99%

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Kooshkaki

Rezaei

Rahmati

et al. 2020

IJMS

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MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in the tissue and plasma of cancer patients when tested in comparison to healthy individuals. In past decades, research data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has been confirmed that miRNAs can act either as oncogenes by silencing tumor inhibitors or as tumor suppressors by targeting oncoproteins. MiR-144s are located in the chromosomal region 17q11.2, which is subject to significant damage in many types of cancers. In this review, we assess the involvement of miR-144s in several cancer types by illustrating the possible target genes that are related to each cancer, and we also briefly describe the clinical applications of miR-144s as a diagnostic and prognostic tool in cancers.Int. J. Mol. Sci. 2020, 21, 2578 2 of 23 of a mRNA molecule [3]. MiRNAs indicate a new perspective in the study of cancers. More than 50% of miRNA genes were discovered to be located within the genomic regions that are involved in cancers, suggesting their role in human cancer pathogenesis. In pathological conditions, MiRNAs can negatively regulate gene expression and they are associated with tumor growth, apoptosis, invasion, and metastasis. In the past, several studies have indicated the ability of miRNAs in the inhibition of tumors as a critical option for the improvement of cancer therapy [4,5]. Tumor activator miRNAs, called oncomiRs, are overexpressed in various cancers. On the contrary, suppressive tumor miRNAs are underexpressed [6][7][8]. Among several miRNAs assessed, miR-144s seem to have a role in several cancers. These miRNAs are located in the chromosomal region 17q11.2, being significantly destroyed in many types of cancers. The predicted stem-loop structure of miR-144s recognized by the miRBase (http://mirbase.org/) is shown in Figure 1A. The miR-144 hairpin gives rise to the "guide strand" miR-144-5p and the sister "passenger" strand miR-144-3p ( Figure 1B).

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“…Real‐time monitoring of miRNAs could refine therapy and identify treatment resistance. Initial studies investigated in vitro response to therapy and a number of therapy‐predictive miRNAs were identified. Studies investigating in vivo response to therapy and circulating miRNAs are limited in that long‐term follow‐up is lacking; however, early results are encouraging ( Table ).…”

Section: Regulation Of Oestrogen Receptor and Her2/neu Expression Andmentioning

confidence: 99%

Role of micro-RNAs in breast cancer surgery

McAnena

Lowery

Kerin

2018

British Journal of Surgery

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MicroRNA-144 affects radiotherapy sensitivity by promoting proliferation, migration and invasion of breast cancer cells

Cited by 53 publications

References 37 publications

Changes in miRNA in the lung and whole blood after whole thorax irradiation in rats

Changes in miRNA in the lung and whole blood after whole thorax irradiation in rats

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Role of micro-RNAs in breast cancer surgery

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