2018
DOI: 10.1128/jvi.02009-17
|View full text |Cite
|
Sign up to set email alerts
|

MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway

Abstract: Hepatitis C virus (HCV) infection has been shown to regulate microRNA 130a (miR-130a) in patient biopsy specimens and in cultured cells. We sought to identify miR-130a target genes and to explore the mechanisms by which miR-130a regulates HCV and hepatitis B virus (HBV) replication. We used bioinformatics software, including miRanda, TargetScan, PITA, and RNAhybrid, to predict potential miR-130a target genes. miR-130a and its target genes were overexpressed or were knocked down by use of small interfering RNA … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

3
38
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
6

Relationship

3
3

Authors

Journals

citations
Cited by 33 publications
(42 citation statements)
references
References 59 publications
(63 reference statements)
3
38
0
Order By: Relevance
“…Huh7.5.1, HepG2, LX2, TWNT4, and Huh7 cells were grown in Dulbecco’s modified Eagle’s medium (Thermo Fisher Scientific, Waltham, MA) supplemented with 10% fetal bovine serum (GIBCO, Waltham, MA) and 1% penicillin/streptomycin (Invitrogen, Waltham, MA) at 37°C with 5% CO 2 . Huh7.5.1 cells were infected with genotype 2a Japanese fulminant hepatitis 1 (JFH1) HCV at a multiplicity of infection of 0.2 (JFH1 cells) as previously described . Primary human hepatocytes (PHHs) were purchased from TRIANGLE Research Laboratories (Durham, NC) and cultured according to the manufacturer’s instructions.…”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations
“…Huh7.5.1, HepG2, LX2, TWNT4, and Huh7 cells were grown in Dulbecco’s modified Eagle’s medium (Thermo Fisher Scientific, Waltham, MA) supplemented with 10% fetal bovine serum (GIBCO, Waltham, MA) and 1% penicillin/streptomycin (Invitrogen, Waltham, MA) at 37°C with 5% CO 2 . Huh7.5.1 cells were infected with genotype 2a Japanese fulminant hepatitis 1 (JFH1) HCV at a multiplicity of infection of 0.2 (JFH1 cells) as previously described . Primary human hepatocytes (PHHs) were purchased from TRIANGLE Research Laboratories (Durham, NC) and cultured according to the manufacturer’s instructions.…”
Section: Methodsmentioning
confidence: 99%
“…Huh7.5.1 cells were infected with genotype 2a Japanese fulminant hepatitis 1 ( JFH1) HCV at a multiplicity of infection of 0.2 ( JFH1 cells) as previously described. (1,19,20) Primary human hepatocytes (PHHs) were purchased from TRIANGLE Research Laboratories (Durham, NC) and cultured according to the manufacturer's instructions. In brief, PHHs were seeded onto matrix-coated plates and cultured with Hepatocyte Plating Medium (Durham, NC).…”
Section: Cells and Virusmentioning
confidence: 99%
See 2 more Smart Citations
“…; Duan et al . ). Furthermore, microRNAs have been detected extracellularly and circulating in the blood, CSF, and other body fluids (Weber et al .…”
mentioning
confidence: 97%