MicroRNA-1298 is downregulated in non-small cell lung cancer and suppresses tumor progression in tumor cells

Abstract

Background: MicroRNAs (miRNAs) have been reported to serve pivotal roles in tumorigenesis. This study sough to assess the expression and clinical significance of microRNA-1298 (miR-1298) in patients with non-small cell lung cancer (NSCLC), and explore the functional role of miR-1298 in tumorigenesis. Methods: One hundred and twenty-one NSCLC patients were recruited in this study. The expression of miR-1298 was estimated using quantitative real-time PCR. Kaplan-Meier survival curves and Cox regression analysis were used to evaluate the prognostic value of miR-1298. Gain-and loss-of-function experiments were preformed to explore the biological function of miR-1298 in NSCLC cells. Results: Expression levels of miR-1298 were downregulated in NSCLC tissues and cells compared with the corresponding normal controls. The decreased expression of miR-1298 was associated with patients' lymph node metastasis and TNM stage. The low expression of miR-1298 predicted poor overall survival and served as an independent prognostic indicator in NSCLC patients. According to the cell experiments, NSCLC cell proliferation, migration and invasion were inhibited by the overexpression of miR-1298. Conclusion: All the data indicated that the downregulation of miR-1298 predicts poor prognosis of NSCLC, and the overexpression of miR-1298 in NSCLC cells leads to inhibited tumorigenesis. The aberrant miR-1298 may serve as a novel biomarker and therapeutic target in NSCLC.

<p>MicroRNA-374b-5p Functions as a Tumor Suppressor in Non-Small Cell Lung Cancer by Targeting FOXP1 and Predicts Prognosis of Cancer Patients</p>

“…25 A recent study by Du et al also demonstrated that the decreased expression of miR-1298 served as a biomarker in NSCLC prognosis. 26 Given the abnormal expression of miR-374b-5p in NSCLC tissues, the relationship between miR-374b-5p and the 5-year survival information was analyzed in NSCLC patients. The survival curves indicated that patients with low miR-374b-5p expression had a shorter survival time, and the Cox regression analysis revealed that miR-374b-5p was an independent prognostic indicator for patients with NSCLC.…”

miR-1298-5p Influences the Malignancy Phenotypes of Breast Cancer Cells by Inhibiting CXCL11

“…10 Another research confirmed the downregulation of miR-1298 in non-small cell lung cancer and its suppressive role in cancer phenotypes. 11 In this study, miR-1298-5p was significantly downregulated in BC tissue samples, and the upregulation of miR-1298-5p significantly impaired cell phenotypes such as the viability, proliferation, colony formation, migration, and adhesion abilities of BC cells. For this reason, we speculated that miR-1298-5p could suppress BC growth.…”

“…It was uncovered in one research that miR-1298-5p played an anti-tumor role in KRAS oncogene-induced tumor growth in vivo and in vitro 10 Moreover, miR-1298 was demonstrated to be downregulated in patients with non-small cell lung cancer, thereby prolonging their survival time. 11 Although the investigation of the effect of miR-1298-5p on BC cells is still limited, it is hypothesized that miR-1298-5p might act as an anti-tumor miRNA in BC based on the previous studies that explored the impact of miR-1298-5p on other cancer types.…”

MiR-1231 decrease the risk of cancer-related mortality in patients combined with non-small cell lung cancer and diabetes mellitus

“…Recently, many miRNAs have been identified as prognostic biomarkers for NSCLC [28]. miR-1298 was found by Du et al to be aberrantly expressed in NSCLC, and aberrant miR-1298 can be used as a prognostic biomarker for NSCLS patients [29]. As a novel biomarker, miR-1231 has been considered as a promising prognostic factor for cancer.…”