MicroRNA-1290 promotes esophageal squamous cell carcinoma cell proliferation and metastasis

Li, Ming; He, Xiaoyan; Zhang, Zhimei; Li, Shuo; Ren, Lihua; Cao, Risheng; Feng, Yadong; Ji, Yin-Lin; Zhao, Ye; Shi, Ruihua

doi:10.3748/wjg.v21.i11.3245

Cited by 44 publications

(38 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are many reports about the positive effects of miR‐1290 on human cancers. For example, miR‐1290 knockdown decreased propagation of non‐small cell lung cancer cells (Kim et al, ), while ectopic miR‐1290 expression potently promoted esophagus cancer cell propagation and metastasis (Li et al, ).…”

Section: Discussionmentioning

confidence: 99%

MiR‐1290 promotes proliferation, migration, and invasion of glioma cells by targeting LHX6

Liu

Cai

Sun

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

To investigate the interaction of miR-1290 and LHX6 in gliomas, and their influence on the propagation and metastasis of glioma cells. The differential expression of miR-1290 in glioma cells was identified by chip screening. The expression level of miR-1290 and LHX6 were determined by qRT-PCR and Western blot. The influence of miR-1290 on propagation of glioma cells were analyzed by MTT assay, EdU incorporation, and colony formation, while the impact of miR-1290 on metastasis was assessed by transwell assay. The relationship between LHX6 and miR-1290 was testified by luciferase reporter assay. The gliomas orthotopic implantation model of nude mice was established to investigate the influence of miR-1290 and LHX6 on tumor growth. Tumor volumes were evaluated by photon density, and the expression of Ki67 protein was analyzed by immunohistochemistry. MiR-1290 presented a higher expression in glioma cells and tissues. MiR-1290 overexpression significantly promoted propagation and metastasis of glioma cells, while miR-1290 knockdown inhibited glioma development. MiR-1290 suppressed LHX6 expression, facilitating development of glioma cells. The orthotopic implantation model showed that miR-1290 overexpression promoted tumor growth while LHX6 overexpression inhibited it. MiR-1290 could promote glioma cell propagation and metastasis by inhibiting LHX6.

show abstract

Section: Discussionmentioning

confidence: 99%

MiR‐1290 promotes proliferation, migration, and invasion of glioma cells by targeting LHX6

Liu

Cai

Sun

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…For instance, miR-1290 was significantly upregulated in ESCC tissue samples, and ectopic miR-1290 expression potently promoted ESCC cell growth, migration and invasion in vitro (25). miR-140 expression was decreased in the EC tissues and regulated the cell invasion of EC via controlling Slug expression (30).…”

Section: Discussionmentioning

confidence: 99%

“…Concerning chemotherapy in various types of cancers such as breast cancer, lung adenocarcinoma, glioblastoma, and ovarian cancer, recent studies have shown that miRNAs also act in important roles (20)(21)(22)(23)(24). In ESCC, altered expression of miR-1290, miR-655, miR-375 and others, has been observed (25)(26)(27), suggesting that miRNA deregulation plays an important role in ESCC development.…”

Section: Introductionmentioning

confidence: 99%

miR-1291 targets mucin 1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma

et al. 2015

View full text Add to dashboard Cite

Abstract. MicroRNAs (miRNAs) are well known as important regulators in various cancer development. In the present study, we focused on the expression and biological function of miR-1291 in esophageal squamous cell carcinoma (ESCC). Compared with adjacent non-tumorous tissue samples, qRT-PCR data showed significant downregulation of miR-1291 in 54 ESCC tissue samples (P<0.05), which was also significantly associated with lymph node metastases and clinical stage (P<0.05). Cell Counting Kit-8 (CCK-8), colony formation, Transwell and flow cytometric apoptosis assays were performed to detect the effect of miR-1291 upregulation, and the results showed inhibition of the proliferation, invasion and promotion of apoptosis in EC9706 and EC-1 cells. Using bioinformatic analyses, we found that mucin 1 (MUC1) was a potential target for miR-1291. Luciferase assays were performed to reveal that miR-1291 inhibited MUC1 expression by targeting the seed region of MUC1 3'-untranslated region (3'UTR). We also found that the expression of MUC1 lacking in 3'UTR abrogated the anti-invasion and pro-apoptosis function of miR-1291. Our results demonstrated the importance of miR-1291 in targeting MUC1 for the regulation of esophagus cancer growth, invasion and apoptosis, and may be helpful for developing new targets for early diagnosis or new therapeutic targets for ESCC.

show abstract

“…Emerging evidence has indicated that SCAI inhibited migration and invasion in human cancers, and SCAI is downregulated in a variety of human tumors [ 35 – 37 ]. An elegant study defined that SCAI suppressed cancer cell invasion through the transcriptional control of β1-integrin [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

MiR-625-3p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells

Zheng

Wang

et al. 2015

Oncotarget

View full text Add to dashboard Cite

MicroRNAs (miRNAs) play a critical role in controlling tumor invasion and metastasis via regulating the expression of a variety of targets, which act as oncogenes or tumor suppressor genes. Abnormally expressed miR-625-3p has been observed in several types of human cancers. However, the molecular mechanisms of miR-625-3p-mediated tumorigenesis are largely elusive. Therefore, the aim of this study was to evaluate the biological function and molecular insight on miR-625-3p-induced oncogenesis in colorectal carcinoma (CRC). The effects of miR-625-3p in cell migration and invasion were analyzed by wound healing assay and transwell assay, respectively. In addition, the expression of miR-625-3p and its targets was detected in five human CRC cell lines. In the present study, we found that overexpression of miR-625-3p promoted migration and invasion in SW480 cells, whereas downregulation of miR-625-3p inhibited cell motility in SW620 cells. More importantly, we observed potential binding sites for miR-625-3p in the 3′-untranslated region of suppressor of cancer cell invasion (SCAI). Notably, we identified that overexpression of miR-625-3p inhibited the expression of SCAI, while depletion of miR-625-3p increased SCAI level, suggesting that SCAI could be a target of miR-625-3p. Additionally, we revealed that miR-625-3p exerts its oncogenic functions through regulation of SCAI/E-cadherin/MMP-9 pathways. Our findings indicate the pivotal role of miR-625-3p in invasion that warrants further exploration whether targeting miR-625-3p could be a promising approach for the treatment of CRC.

show abstract

MicroRNA-1290 promotes esophageal squamous cell carcinoma cell proliferation and metastasis

Abstract: Our findings suggested that miR-1290 may play an oncogenic role in cellular processes of ESCC.

Cited by 44 publications

References 18 publications

MiR‐1290 promotes proliferation, migration, and invasion of glioma cells by targeting LHX6

MiR‐1290 promotes proliferation, migration, and invasion of glioma cells by targeting LHX6

miR-1291 targets mucin 1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma

MiR-625-3p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells

Contact Info

Product

Resources

About