MicroRNA-129-5p suppresses nasopharyngeal carcinoma lymphangiogenesis and lymph node metastasis by targeting ZIC2

Yu, Dan; Han, Guanghong; Zhao, Xue; Liu, Xueshibojie; Xue, Kai; Wang, Di; Xu, Chengbi

doi:10.1007/s13402-019-00485-5

Cited by 29 publications

(28 citation statements)

References 48 publications

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“…This finding suggested that miR-503-5p may play an unknown role in the effect of tobacco on SCCHN. In general, miRNAs exert diverse regulatory roles through target differential mRNAs [11,14,16,22,40], same for miR-223-3p and miR-204-5p. Considering the potential clinical significance of miR-223-3p and miR-204-5p, it is necessary and worthy to define the possible targets for providing reference for the followed study.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from the complicated and varied effect mechanisms, pan-cancer character is also responsible for its rising concern. For the same miRNA, it may be involved in various biological behaviors of multiple cancers, which accelerated the widespread development of the related studies, such as the regulatory effects of miR-129-5p on liver cancer, rectal adenocarcinoma, nasopharyngeal carcinoma, and prostate cancer [ 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance and potential mechanisms of miR-223-3p and miR-204-5p in squamous cell carcinoma of head and neck: a study based on TCGA and GEO

et al. 2020

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ObjectiveTo explore the clinical significance and mechanisms of altered miRNAs in squamous cell carcinoma of head and neck (SCCHN) and provide references for SCCHN diagnosis and prognosis.MethodDifferential expressed miRNAs (DEMs) in SCCHN were screened through gene expression omnibus (GEO) DataSets and verified by the cancer genome atlas (TCGA) database. Next, the overall survival analysis, receiver operating characteristics, and clinical correlation analysis were adopted to filter the miRNAs with diagnostic and prognostic values. Finally, functional enrichment analyses were conducted for inquiring into the mechanisms of miRNAs.ResultsTotal 103 DEMs (p < 0.05, fold change ≥ 2) in SCCHN were screened out from GSE124566. Partly, the expression levels of the selected (12/17) miRNAs were verified by TCGA. Followed, of the 12 miRNAs, two miRNA expression levels were associated with the overall survival, and five miRNAs showed diagnostic values (AUC ≥ 0.85). Besides, miR-223-3p and miR-204-5p expression levels were correlated to certain clinical features. Epithelial–mesenchymal transition (EMT) related biological process and energy metabolism controlling related AMPK signaling pathway might mediate the roles of miR-223-3p and miR-204-5p, respectively.ConclusionWith diagnostic and prognostic values, miR-223-3p and miR-204-5p may be involved in the progression of SCCHN through EMT-related biological process and energy balance related AMPK signaling pathway, respectively.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical significance and potential mechanisms of miR-223-3p and miR-204-5p in squamous cell carcinoma of head and neck: a study based on TCGA and GEO

et al. 2020

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“…Furthermore, the regulatory effects of the different regulatory elements are diverse, such as the regulation of EMT (23)(24)(25). Meanwhile, the same regulatory elements may exert different regulatory roles in different biomolecules or biological processes, such as the regulatory roles of miR-129-5p, for instance (10)(11)(12)(13). It is imperative and significant that the critical roles or biological processes of these regulatory elements are explored, especially for the reported functional molecules.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, miR-6089 could suppress the Wnt/β-catenin signaling pathway and EMT through targeting the myosin heavy chain 9 (MYH9) (26). Similarly, miR-129-5p could inhibit the progression of the malignant phenotype of multiple tumors by directly down-regulating different target mRNAs, including calcium/calmodulin dependent protein kinase IV (CAMK4), ZIC family member 2 (ZIC2), E2F transcription factor 7 (E2F7), and many others (10)(11)(12)(13)27). After proving the complexity and diversity of miRNA biological functions, these studies also showed that the same miRNA could regulate multiple mRNAs and participate in different biological processes.…”

Section: Discussionmentioning

confidence: 99%

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Expression and regulatory network of miRNAs in head and neck squamous cell carcinoma

Zhao¹,

Tian²,

ErBin³

et al. 2020

Transl Cancer Res TCR

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Background: Head and neck squamous cell carcinoma (HNSCC) has the sixth-highest incidence rate of all malignant tumors. The occurrence and progress of HNSCC are induced by extensive molecular changes, resulting in a poor prognosis. The present study aims to explore how altered microRNAs (miRNAs) and their co-expression networks of miRNAs-target mRNAs in HNSCC and to provide references for diagnosis and therapy research. Methods: The reported miRNAs that were ectopically expressed in HNSCC were partly summarized and classified according to the research outcomes. Next, the target mRNAs of miRNAs were predicted using data from online databases. Following that, the co-expression networks between miRNAs and target mRNAs were constructed using Cytoscape. Next, a series of functional enrichment analyses were completed using online databases. Results: A total of 132 miRNAs were summarized using data retrieved from the published literature and then were classified into three grades: A [92], B [18], C [22], according to the research content. Based on these grades, the target mRNAs of the miRNAs in each grade were predicted through data from online databases, and the co-expression networks were constructed separately. Functional enrichment analyses showed that miRNAs participated in multiple molecular functions, biological processes, and signaling pathways. The PI3K-Akt, MAPK, and Wnt signaling pathways, were determined to be regulatory pathways of epithelial-mesenchymal transition (EMT), for instance. Conclusions: A total of 132 altered miRNAs took part in the regulation of the PI3K-Akt, MAPK, Wnt signaling pathways, and other significant pathways or functions. The present study suggests that miRNAs might be key biomarkers for the diagnosis and therapy of HSNCC.

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Hypoxic nasopharyngeal carcinoma‐derived exosomal miR‐455 increases vascular permeability by targeting ZO‐1 to promote metastasis

Xie

Zhang

You

et al. 2023

Molecular Carcinogenesis

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Nasopharyngeal carcinoma (NPC), the most frequent reason for treatment failure in head and neck tumors, has the greatest incidence of distant metastases. Increased vascular permeability facilitates metastasis. Exosomal microRNAs (miRNAs) have been implicated in the development of the premetastatic niche and are emerging as prospective biomarkers in cancer patients. We discovered that a higher level of miR‐455 was connected to a larger propensity for NPC metastasis based on deep sequencing and RT‐qPCR. We found that hypoxia promoted NPC exosomes release and increased miR‐455 expression in a way that was hypoxia‐inducible factor 1‐alpha (HIF‐1α) dependent. Exosomes from NPC cells with high levels of miR‐455 were found to specifically target zonula occludens 1 (ZO‐1), increasing the permeability of endothelial monolayers in vitro vascular permeability and transendothelial invasion experiments. Additional in vivo studies showed that zebrafish with sustained miR‐455‐overexpressing NPC cell xenografts displayed increased tumor cell mass throughout the body. In vivo, zebrafish vascular tight junction integrity was disrupted by exosomes produced by NPC cells with elevated miR‐455 expression. Mice‐bearing xenografts further supported the finding that exosomes containing miR‐455 might reduce ZO‐1 expression in addition to promote NPC cell growth. These findings suggest that in a hypoxic microenvironment, exosomal miR‐455 released by NPC cells enhances vascular permeability and promotes metastasis by targeting ZO‐1. The HIF‐1α‐miR‐455‐ZO‐1 signaling pathway may be a promising predictor and potential therapeutic target for NPC with metastasis.

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MicroRNA-129-5p suppresses nasopharyngeal carcinoma lymphangiogenesis and lymph node metastasis by targeting ZIC2

Cited by 29 publications

References 48 publications

Clinical significance and potential mechanisms of miR-223-3p and miR-204-5p in squamous cell carcinoma of head and neck: a study based on TCGA and GEO

Clinical significance and potential mechanisms of miR-223-3p and miR-204-5p in squamous cell carcinoma of head and neck: a study based on TCGA and GEO

Expression and regulatory network of miRNAs in head and neck squamous cell carcinoma

Hypoxic nasopharyngeal carcinoma‐derived exosomal miR‐455 increases vascular permeability by targeting ZO‐1 to promote metastasis

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