MicroRNA-126 Regulates Thrombosis Through Endothelial Progenitor Cells

Xiao, Qian; Wang, Dan; Sheng, Yingda; Huang, Jing; Ha, Xiaoqin

doi:10.1089/dna.2022.0643

Cited by 1 publication

(1 citation statement)

References 64 publications

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“…Currently, the mechanisms of the incomplete resolution of venous thrombi in patients with DVP and patients who have suffered PE are completely unknown. It has been shown that the process of the fibrotic transformation of thrombotic masses is inextricably linked with the activities of inflammation and angiogenesis, as well as changes in the hemostasis system, in the regulation of which microRNAs (miRNAs) may take part [5,6]. It has been proven that miRNAs play a significant role in various biological processes, including the cell cycle, apoptosis, proliferation, and differentiation, regulating the expression of about 90% of all human genes.…”

Section: Introductionmentioning

confidence: 99%

MiRNAs and Their Role in Venous Thromboembolic Complications

Gareev,

Pavlov,

et al. 2023

Diagnostics

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Venous thromboembolic complications (VTCs), which include deep vein thrombosis (DVT) and pulmonary embolism (PE), have remained a pressing problem in modern clinical medicine for a long time. Despite the already wide arsenal of modern methods for diagnosing and treating this disease, VTCs rank third in the structure of causes of death among all cardiovascular diseases, behind myocardial infarction (MI) and ischemic stroke (IS). Numerous studies have confirmed the importance of understanding the molecular processes of VTCs for effective therapy and diagnosis. Significant progress has been made in VTC research in recent years, where the relative contribution of microRNAs (miRNAs) in the mechanism of thrombus formation and their consideration as therapeutic targets have been well studied. In this case, accurate, timely, and as early as possible diagnosis of VTCs is of particular importance, which will help improve both short-term and long-term prognoses of patients. This case accounts for the already well-studied circulating miRNAs as non-invasive biomarkers. This study presents currently available literature data on the role of miRNAs in VTCs, revealing their potential as therapeutic targets and diagnostic and prognostic tools for this terrible disease.

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Section: Introductionmentioning

confidence: 99%