MicroRNA-126 is a prospective target for vascular disease

Qu, Meijie; Pan, Jiaji; Shi, Xiaojing; Zhang, Zhijun; Tang, Yaohui; Yang, Guo‐Yuan

doi:10.20517/2347-8659.2018.01

Cited by 18 publications

(17 citation statements)

References 41 publications

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“…However, miR-126 modulates C-X-C chemokine receptor type 4 (CXCR4) protein levels during atherosclerosis. As a result, SDF-1 is released and increase the recruitment of endothelial progenitor cells to the atheroma plaque [77]. Nowadays, miR-126 has been described as a dual regulator of atherosclerosis [77].…”

Section: The Physio-pathological Role Of Hif In Agingmentioning

confidence: 99%

“…As a result, SDF-1 is released and increase the recruitment of endothelial progenitor cells to the atheroma plaque [77]. Nowadays, miR-126 has been described as a dual regulator of atherosclerosis [77]. On the one hand, miR-126 induced SDF-1, which promoted endothelial progenitor cells during atheroma formation.…”

Section: The Physio-pathological Role Of Hif In Agingmentioning

confidence: 99%

“…As a consequence, VCAM-1 expression is inhibited and EC proliferation limited atherosclerosis progression. In this way, atherosclerosis formation is impeded and miR-126 shows a beneficial role in atherosclerosis [76,77]. On the other hand, few studies showed that miR-126 presents adverse effects in atherosclerosis.…”

Section: The Physio-pathological Role Of Hif In Agingmentioning

confidence: 99%

See 2 more Smart Citations

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

Alique

Sánchez-López

Bodega

et al. 2020

Cells

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Aging is one of the hottest topics in biomedical research. Advances in research and medicine have helped to preserve human health, leading to an extension of life expectancy. However, the extension of life is an irreversible process that is accompanied by the development of aging-related conditions such as weakness, slower metabolism, and stiffness of vessels. It also debated that aging can be considered an actual disease with aging-derived comorbidities, including cancer or cardiovascular disease. Currently, cardiovascular disorders, including atherosclerosis, are considered as premature aging and represent the first causes of death in developed countries, accounting for 31% of annual deaths globally. Emerging evidence has identified hypoxia-inducible factor-1α as a critical transcription factor with an essential role in aging-related pathology, in particular, regulating cellular senescence associated with cardiovascular aging. In this review, we will focus on the regulation of senescence mediated by hypoxia-inducible factor-1α in age-related pathologies, with particular emphasis on the crosstalk between endothelial and vascular cells in age-associated atherosclerotic lesions. More specifically, we will focus on the characteristics and mechanisms by which cells within the vascular wall, including endothelial and vascular cells, achieve a senescent phenotype.

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Section: The Physio-pathological Role Of Hif In Agingmentioning

confidence: 99%

Section: The Physio-pathological Role Of Hif In Agingmentioning

confidence: 99%

Section: The Physio-pathological Role Of Hif In Agingmentioning

confidence: 99%

See 1 more Smart Citation

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

Alique

Sánchez-López

Bodega

et al. 2020

Cells

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show abstract

“…Given the role of miR-126 in regulating cell migration, vascular adhesion, vascularization and subsequently wound healing, it should be considered as a serious candidate for the treatment of vascular defects, including diabetic complications (Qu et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Plasma miR-126 levels and its genomic polymorphism SNP rs4636297 in Type 2 diabetes

Rezai

Shahbazi

Mansournia

2020

APJMBB

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Since the variation of microRNAs expression has been described in type2 diabetes, we aimed to evaluate the plasma levels of miR-126 with known roles in the angiogenesis. Genomic polymorphism of miR-126 (SNP rs4636297) was also assessed as it is involved in the processing of pri-miR-126 to mature microRNA.Genotyping of the SNP rs4636297 was carried out by PCR-RFLP using HaeII enzyme. Real-time PCR assay was applied to assess miR-126 expression, which the fold change in gene expression was calculated by the Relative Expression Software Tool (REST). Data analysis was performed using exact-like logistic regression, Fisher exact test and the elrm package with the R software. Our data indicated that the group with BMI greater than 30 was at greater risk of diabetes (odds ratio=14.4, p value=0.00), compared with the BMI=19-25. The mean fold decrease in miR-126 gene expression in diabetic samples relative to normal samples was 0.653 (95% confidence interval: 0.012 - 18.765). All patients with the lowest levels of miR-126, had experienced diabetic complications. Considering the AA genotype as the reference, the odds ratio of diabetic complications for the GG and AG genotype were 1.2 and 1.43, respectively. miR-126 is one of the key factors in predisposition to diabetes and diabetic complication. Since the lowest expression of miR-126 leads to the diabetic complications it can be concluded that genetic predisposing factors should be considered in the management and treatment of Type 2 diabetes.

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“…Elevated levels of miR-126 may play a functional role in DA neurons and in PD pathogenesis by downregulating insulin signaling [157]. It has been reported that miR-126 is involved in the mechanism of ROS production [158]. Moreover, the altered expression of miR-126 is associated with insufficient sleep [64].…”

Section: Parkinson's Diseasementioning

confidence: 99%

MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases

et al. 2020

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Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and the timing of biological systems to optimize physiology and behavior for the environmental day/night cycles. The systems are basically generated by transcription–translation feedback loops combined with post-transcriptional and post-translational modification. Recently, evidence is emerging that additional non-coding RNA-based mechanisms are also required to maintain proper clock function. MicroRNA is an especially important factor that plays critical roles in regulating circadian rhythm as well as many other physiological functions. Circadian misalignment not only disturbs the sleep/wake cycle and rhythmic physiological activity but also contributes to the development of various diseases, such as sleep disorders and neurodegenerative diseases. The patient with neurodegenerative diseases often experiences profound disruptions in their circadian rhythms and/or sleep/wake cycles. In addition, a growing body of recent evidence implicates sleep disorders as an early symptom of neurodegenerative diseases, and also suggests that abnormalities in the circadian system lead to the onset and expression of neurodegenerative diseases. The genetic mutations which cause the pathogenesis of familial neurodegenerative diseases have been well studied; however, with the exception of Huntington’s disease, the majority of neurodegenerative diseases are sporadic. Interestingly, the dysfunction of microRNA is increasingly recognized as a cause of sporadic neurodegenerative diseases through the deregulated genes related to the pathogenesis of neurodegenerative disease, some of which are the causative genes of familial neurodegenerative diseases. Here we review the interplay of circadian rhythm disruption, sleep disorders and neurodegenerative disease, and its relation to microRNA, a key regulator of cellular processes.

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MicroRNA-126 is a prospective target for vascular disease

Cited by 18 publications

References 41 publications

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

Plasma miR-126 levels and its genomic polymorphism SNP rs4636297 in Type 2 diabetes

MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases

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