MicroRNA‑126: A new and promising player in lung cancer (Review)

Abstract

Lung cancer is one of the most common malignant tumors associated with cancer death; however, the mechanisms involved in lung tumor development have not been completely elucidated, which impedes the advancement of clinical diagnosis and therapy. MicroRNA-126 (miR-126) is an important member of the microRNA family and is encoded by intron 7 of epidermal growth factor-like domain-containing gene 7. Increasing evidence has demonstrated that miR-126, as a distinct endothelial-enriched miRNA and new tumor suppressor gene, serves a promising role in the occurrence, development and metastasis of various types of cancer, including liver cancer, colorectal cancer, melanoma and lung cancer. In the present review, the current knowledge of the role of miR-126 in lung cancer growth, metastasis, diagnosis and prognosis as well as therapy was summarized, which may provide new insights on the biological roles of miRNAsin lung cancer and facilitate the ultimate development of miRNA-based therapies in clinical patients with non-small cell lung cancer.

Long non‑coding RNA SLC25A25‑AS1 exhibits oncogenic roles in non‑small cell lung cancer by regulating the microRNA‑195‑5p/ITGA2 axis

“…By directly binding to the 3'-untranslated regions of their target genes, miRNAs can promote translation suppression or degrade mRNAs, thereby regulating gene expression (17). Additionally, miRNAs have an effect on the oncogenesis and progression of NSCLC by controlling a wide range of biological behaviours (18)(19)(20). lncRNAs can operate as competitive endogenous RNAs (ceRNAs) by competitively binding to miRNAs and weakening the miRNA-mediated inhibitory effects on mRNA expression, thereby controlling gene expression at the posttranslational level (21)(22)(23).…”

Characterization of Differentially Expressed Circulating miRNAs in Metabolically Healthy versus Unhealthy Obesity

“…Additionally, miR-126 inactivates the PI3K/AKT pathway in the carcinogenesis process [ 36 ]. Increasing evidence supports that, as a new tumour suppressor gene, miR-126 plays a role in the development and metastasis of various types of cancer, such as lung cancer, liver cancer, melanoma and colorectal cancer [ 37 ].…”

Coxsackievirus B3—Its Potential as an Oncolytic Virus

“…Many miRs are expressed differentially in tissues and organs [123][124][125]. Cancer cells also differ in their miR expression profile compared to healthy tissues [126,127]. To make OV sensitive for miRs, they are equipped with miR target sites (miR-TS) which correspond to miRs that are abundantly expressed in healthy tissues but poorly expressed or absent in tumor cells.…”