MicroRNA-125b promotes invasion and metastasis of gastric cancer by targeting STARD13 and NEU1

Chang, Shuai; He, Shicai; Qiu, Guanglin; Lü, Jing; Wang, Jin; Liu, Junsong; Fan, Lin; Zhao, Wei; Che, Xiangming

doi:10.1007/s13277-016-5094-y

Cited by 40 publications

(30 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The particular role of microRNA’s, however, seems to be complex and depending on the tumor entity. For example, miR-125b has been shown to be upregulated in tissue of gastric cancer and to enhance spread of gastric cancer metastases43, but to inhibit formation of metastases in hepatocellular carcinoma44. We did not aim to assess a potential relation between ascites microRNA and malignancy in our study.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis

Lutz

Haimid

Pohlmann

et al. 2017

Sci Rep

View full text Add to dashboard Cite

MircoRNA’s (miR) have been recognised as important modulators of gene expression and potential biomarkers. However, they have been rarely investigated in bio fluids apart from blood. We investigated the association of miR-125b and miR-155 with complications of cirrhosis. Ascites was prospectively collected from patients with cirrhosis undergoing paracentesis at our department. miR’s were determined in the supernatant using qPCR and normalized by SV-40. Clinical parameters were assessed at paracentesis and during follow-up. 76 specimens from 72 patients were analysed. MiR’s were not associated to age, sex or aetiology of cirrhosis. MiR-125b levels differed between patients with low and high MELD score, and miR-125b levels showed an inverse correlation to serum creatinine (r2 = −0.23; p = 0.05). MiR-155 was elevated in patients with spontaneous bacterial peritonitis (SBP) (n = 10; p = 0.04). MiR-155 levels differed between patients with and without 30-day survival (p = 0.02). No association of ascites levels of investigated miR’s to size of varices, episodes of gastrointestinal bleeding or hepatorenal syndrome was observed. While miR-125b levels in ascites seem to be associated with liver and renal dysfunction, miR-155 might be implicated in local immune response in SBP.

show abstract

Section: Discussionmentioning

confidence: 99%

MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis

Lutz

Haimid

Pohlmann

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Various targets of miR‐125b, including STARD13, HK2, NEU1, TNFAIP3, and NKIRAS, have been recognized and confirmed in many studies. In our previous study, STAT3 was identified as the direct target of miR‐125b .…”

Section: Discussionmentioning

confidence: 87%

MiR‐125b suppresses the carcinogenesis of osteosarcoma cells via the MAPK‐STAT3 pathway

Xiao

Xiong

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

The microRNA (miRNA) miR‐125b is abnormally expressed in many different types of tumors, including osteosarcoma (OS). How aberrantly expressed miR‐125b participates in regulating the initiation and progression of OS is still poorly understood. In the current study, we found that in OS, miR‐125b can suppress the expression of MAP kinase kinase 7 (MKK7), which can dephosphorylate and inactivate signal transducer and activator of transcription 3 (STAT3). We also identified an elevated expression level of MKK7 in OS and an association between MKK7 expression and poor prognosis. Further, miR‐125b inhibited OS cell proliferation and invasion by targeting and downregulating MKK7 in vitro and suppressed tumor formation in vivo. Moreover, using Western blot analysis, we preliminarily proved that the activation (phosphorylation) of STAT3 was regulated by MKK7 at the epigenetic level. MKK7 was overexpressed in OS and associated with poor clinical results. The miR‐125b‐MAPK‐STAT3 axis may be one of the mechanisms of OS oncogenesis and a potential target for the treatment of OS.

show abstract

“…Kato et al (69) has reported that NEU1 overexpression resulted in suppression of lung metastasis in melanoma. In addition, suppression of NEU1 by miR-125b has been shown to promote migration, invasion and metastasis in gastric cancers (70). However, NEU1 can also have pro-metastatic effects in pancreatic and ovarian cancers (71), and thus it is not entirely clear what the overall impact of increased NEU1 levels might be in prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Effects of genistein supplementation on genome-wide DNA methylation and gene expression in patients with localized prostate cancer

Bilir

Sharma

Lee

et al. 2017

International Journal of Oncology

View full text Add to dashboard Cite

Epidemiological studies have shown that dietary compounds have significant effects on prostate carcinogenesis. Among dietary agents, genistein, the major isoflavone in soybean, is of particular interest because high consumption of soy products has been associated with a low incidence of prostate cancer, suggesting a preventive role of genistein in prostate cancer. In spite of numerous studies to understand the effects of genistein on prostate cancer, the mechanisms of action have not been fully elucidated. We investigated the differences in methylation and gene expression levels of prostate specimens from a clinical trial of genistein supplementation prior to prostatectomy using Illumina HumanMethylation450 and Illumina HumanHT-12 v4 Expression BeadChip Microarrays. The present study was a randomized, placebo-controlled, double-blind clinical trial on Norwegian patients who received 30 mg genistein or placebo capsules daily for 3–6 weeks before prostatectomy. Gene expression changes were validated by quantitative PCR (qPCR). Whole genome methylation and expression profiling identified differentially methylated sites and expressed genes between placebo and genistein groups. Differentially regulated genes were involved in developmental processes, stem cell markers, proliferation and transcriptional regulation. Enrichment analysis suggested overall reduction in MYC activity and increased PTEN activity in genistein-treated patients. These findings highlight the effects of genistein on global changes in gene expression in prostate cancer and its effects on molecular pathways involved in prostate tumorigenesis.

show abstract

MicroRNA-125b promotes invasion and metastasis of gastric cancer by targeting STARD13 and NEU1

Cited by 40 publications

References 57 publications

MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis

MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis

MiR‐125b suppresses the carcinogenesis of osteosarcoma cells via the MAPK‐STAT3 pathway

Effects of genistein supplementation on genome-wide DNA methylation and gene expression in patients with localized prostate cancer

Contact Info

Product

Resources

About