microRNA-124 targets glucocorticoid receptor and is involved in depression-like behaviors

Respiratory syncytial virus nonstructural protein 1 downregulates glucocorticoid receptor expression through miR-29a

“…5 Other studies showed that downregulated GR levels were associated with an increase in the microRNAs (miRNAs) miR-124-3p, miR-142-3p, and miR-29a. 3,6,7 Here we investigated how RSV infection regulates GR expression mediated by miRNAs. We hypothesized that miR-29a, which is regulated by RSV nonstructural 1 (NS1) protein, is responsible for downregulation of GR expression.…”

“…4 Recently, 2 consortiums published the results of large meta-analyses of genome-wide association studies (GWASs), which doubled the number of genetic variants that are associated with asthma. 5,6 The Trans-National Asthma Genetic Consortium (TAGC) described 18 loci to be associated with asthma in a multiancestry meta-analysis in 142,000 subjects, 5 with 5 additional loci specifically related to pediatric asthma. Moreover, the SHARE consortium discovered 136 independent genetic variants to be associated with allergic disease (asthma, hay fever, or eczema) in 360,000 subjects, with almost all variants contributing to either disease.…”

“…Moreover, the SHARE consortium discovered 136 independent genetic variants to be associated with allergic disease (asthma, hay fever, or eczema) in 360,000 subjects, with almost all variants contributing to either disease. 6 These asthma-associated variants from the TAGC and SHARE consortiums offer the opportunity to investigate asthma prediction based on genetic risk scores (GRSs).…”

The role of microRNAs in glucocorticoid action

“…This neuronally expressed miRNA targets the Nr3c1 3ЈUTR to downregulate GR expression (28 -32). It can be induced by GCs (28,(32)(33)(34), suggesting that it may contribute to negative-feedback regulation of GC sensitivity. In rats (31,34) and mice (32), elevated miR-124-3p levels in the brain were associated with decreased GR levels and GC sensitivity and increased depression-like symptoms.…”

“…In rats (31,34) and mice (32), elevated miR-124-3p levels in the brain were associated with decreased GR levels and GC sensitivity and increased depression-like symptoms. Furthermore, treatment of mice with an miR-124-3p antagonist (antagomir) reduced depression-related behaviors (32). Levels of miR-124-3p were reportedly elevated in peripheral blood of patients with severe depression (35,36).…”