MicroRNA-124 negatively regulates STAT3 to alleviate hypoxic-ischemic brain damage by inhibiting oxidative stress
Jiaqing Geng,
Jiangpeng Feng,
Fangzi Ke
et al.
Abstract:MicroRNA-124 (miR-124)
is implicated in various neurological diseases; however, its significance in hypoxic-ischaemic brain damage (HIBD) remains unclear. This study aimed to elucidate the underlying pathophysiological mechanisms of
miR-124
in HIBD. In our study performed on oxygen-glucose deprivation followed by reperfusion (OGD)/R-induced primary cortical neurons, a substantial reduction in
miR-124
was observed. Furthermore, the upregulation of
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