MicroRNA-124 (miR-124) Regulates Ku70 Expression and is Correlated with Neuronal Death Induced by Ischemia/Reperfusion

Zhu, Fei; Liu, Jingli; Li, Jinping; Xiao, Fang; Zhang, Zhaoxia; Zhang, Lei

doi:10.1007/s12031-013-0155-9

Cited by 90 publications

(66 citation statements)

References 35 publications

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“…Several groups reported a high increase of miR-124 level within the first 24 he48 h after reperfusion in rodent stroke models [13,27,28]. However, reports on the exact temporal profile are conflicting [27,29,30]. Interestingly, in humans, miR-124 was reported to be decreased 24 h after stroke onset and was found to be negatively correlated to the infarct size [31].…”

Section: Direct Effects Of Mir-124 On Neuronal Survivalmentioning

confidence: 99%

MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

et al. 2016

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Section: Direct Effects Of Mir-124 On Neuronal Survivalmentioning

confidence: 99%

MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

et al. 2016

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“…miRNAs play an important role in IRI, such as myocardial [4,5], hepatic [6,7], cerebral [8] IRI. Recently, microRNAs have come into focus as powerful regulators of gene expression and potential diagnostic tools during renal IRI.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-21 Attenuates Renal Ischemia Reperfusion Injury via Targeting Caspase Signaling in Mice

Jiang

et al. 2014

Am J Nephrol

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Background: MicroRNAs (miR) have come into focus as powerful regulators of gene expression and potential diagnostic tools during renal ischemia reperfusion injury (IRI). The aim of this study was to investigate the molecular regulation and function of miR-21, and to analyze the relationship between caspases and miR-21 expression levels in an experimental model of renal IRI. Methods: IRI was induced by bilateral renal ischemia for 45 min followed by reperfusion. The male BALB/c mice were randomly assigned to the following groups: pre-miR-21 + IRI group, antagomiR-21 + IRI group, PBS + IRI group, pre-miR-21 + sham operation group, antagomiR-21 + sham operation group, PBS + sham operation group. The pre-miR-21 or antagomiR-21 was administered intraperitoneally (200 ng/kg weight) 24 and 6 h before induction of ischemia. Renal function, histological damage, renal cell apoptosis proteins were evaluated at 24 h after reperfusion. Results: Mice upregulated miR-21 had lower plasma levels of blood urea nitrogen (BUN) and creatinine, lower histopathological scores and a decrease in programmed cell death 4 (PDCD4) mRNA and active caspase-3, caspase-8 proteins expressions. Conclusions: miR-21 is endowed with anti-apoptotic properties by suppressing the expression of PDCD4 gene and active caspase 3/8 fragments in the condition of renal IRI. miR-21 exerts significant functional protection in our renal murine model of IRI.

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“…MiRNAs are regulators of target genes and miRNA-target gene pairs play important roles in biological behaviors. miR-124 is identified to be an endogenous regulator of Ku70 that improves I/R-induced brain injury [8]. Thus, in our study, the roles of miRNA-target gene pairs in I/R development were investigated.…”

Section: Introductionmentioning

confidence: 99%

Revealing the Underlying Mechanism of Ischemia Reperfusion Injury Using Bioinformatics Approach

Shen

Zhou

et al. 2013

Kidney Blood Press Res

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Background/Aims: To reveal the potential pathogenesis of ischemia/reperfusion (I/R) injury. Methods: GSE9943 were downloaded from Genome Expression Omnibus database, including I/R and control samples for both Brown Norway (BN) and Sprague Dawley (SD) rats (3 rats/each group). Then differentially expressed genes (DEGs) were identified by limma package. miRNA-target gene network pairs were predicted using WebGestalt, and protein-protein interactions (PPI) were identified based on STRING database, followed by the networks construction using Cytoscape. Next, ClusterONE was used for modules screening. Furthermore, functional analyses were performed to common DEGs and genes. Results: Totally, 23 common DEGs of BR and SD rats were screened, enriched in functions, such as regulation of cellular protein metabolic process, response to wounding, proteinaceous extracellular matrix, and Enzyme inhibitor activity. MIR-29A, MIR-29B and MIR-29C were discovered both in up- and down-regulated miRNA-target gene networks. Genes in the PPI network were significantly disturbed in p53 signaling, complement and coagulation cascades pathway. Four modules were found significantly disturbed cytochrome P450, Serine/threonine protein kinase, calcium binding and Transient receptor potential channel protein domains. Conclusion: During I/R injury, many genes mutated, interrupting several biological functions, pathways and protein domains. MIR-29C and TRPC6 were suggested to be potential novel targets for this disease.

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MicroRNA-124 (miR-124) Regulates Ku70 Expression and is Correlated with Neuronal Death Induced by Ischemia/Reperfusion

Cited by 90 publications

References 35 publications

MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

MicroRNA-21 Attenuates Renal Ischemia Reperfusion Injury via Targeting Caspase Signaling in Mice

Revealing the Underlying Mechanism of Ischemia Reperfusion Injury Using Bioinformatics Approach

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