MicroRNA-124 inhibits proliferation, invasion, migration and epithelial-mesenchymal transition of cervical carcinoma cells by targeting astrocyte-elevated gene-1

Zhang, Xia; Dajun, Cai; Liu, Meng; Wang, Bing

doi:10.3892/or.2016.5025

Cited by 32 publications

(26 citation statements)

References 30 publications

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“…An et al (30) demonstrated that miR-124 inhibits glioma cell migration and invasion via the inhibition of ROCK1. Zhang et al (31) reported that miR-124 inhibits the proliferation, invasion, migration and epithelial-mesenchymal transition (EMT) of cervical carcinoma cells by targeting astrocyte-elevated gene-1. Of note, Huang et al (32) demonstrated that knockdown of miR-124 promoted neuroblastoma cell differentiation, cell cycle arrest and apoptosis, which suggests that it may have an oncogenic role in neuroblastoma.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑124 inhibits cell proliferation, invasion and migration by targeting CAV1 in bladder cancer

Zhou

Dai

et al. 2018

Exp Ther Med

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MicroRNAs (miRs) may have promotive or suppressive roles in various human cancers types, but the molecular mechanisms underlying the role of miR-124 in bladder cancer (BC) progression have remained largely elusive. In the present study, it was observed that miR-124 was significantly downregulated in BC tissues compared with that in adjacent non-neoplastic tissues. Furthermore, its expression was also reduced in several human BC cell lines (T24, HT-1376 and 5637) compared with that in the normal bladder epithelial SV-HUC-1 cell line. A low expression of miR-124 in BC patients was significantly associated with advanced malignancy and a poor prognosis. Caveolin 1 (CAV1) was identified as a novel target gene of miR-124, and the expression of CAV1 was negatively regulated by miR-124 in T24 cells. Furthermore, CAV1 was identified to be significantly upregulated in BC tissues and cell lines, and a negative correlation was observed between the expression of miR-124 and CAV1 in BC tissues. Furthermore, restoration of miR-124 expression significantly inhibited the proliferation, migration and invasion of T24 cells, and these effects were impaired following overexpression of CAV1. Taken together, the present results demonstrate that miR-124 has a suppressive role in the proliferation, migration and invasion of BC cells by targeting CAV1, which suggests that miR-124 is a potential therapeutic candidate for BC.

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Section: Discussionmentioning

confidence: 99%

MicroRNA‑124 inhibits cell proliferation, invasion and migration by targeting CAV1 in bladder cancer

Zhou

Dai

et al. 2018

Exp Ther Med

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“…The poor prognosis of patients with advanced cervical cancer is largely attributed to intrinsic molecular changes (2,3). During the growth and metastasis of cervical cancer, various oncogenes and tumor suppressors have been demonstrated to serve key roles, and some of these are suggested to become potential therapeutic targets for cancer treatment (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑302 inhibits cell migration and invasion in cervical cancer by targeting DCUN1D1

Jiang

Hou

et al. 2018

Exp Ther Med

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Abstract. MicroRNA serve crucial roles in a variety of human cancer types. The miR-302-367 cluster has been reported to suppress the proliferation of cervical carcinoma cells through the novel target AKT1; however, the molecular mechanism of miR-302 in cervical cancer metastasis remains unclear. The present study aimed to investigate the clinical significance of miR-302-3p expression in cervical cancer, and to examine the regulatory mechanism of miR-302-3p in the malignant phenotypes of cervical cancer cells. The present data indicated that miR-302-3p was significantly downregulated in cervical cancer tissues compared with the level in adjacent non-tumor tissues, and low expression of miR-302-3p was significantly associated with node metastasis, advanced clinical stage, and poor prognosis in patients with cervical cancer. Restoration of miR-302-3p expression caused a significant reduction in cervical cancer cell migration and invasion. Defective in cullin neddylation 1 domain containing 1 (DCUN1D1) was identified as a novel target gene of miR-302-3p, and miR-302-3p negatively regulated the mRNA and protein expression of DCUN1D1 in cervical cancer HeLa cells. Additionally, overexpression of DCUN1D1 rescued the effects of miR-302-3p on the migration and invasion of cervical cancer cells. Furthermore, DCUN1D1 was upregulated in cervical cancer tissues compared with the levels in adjacent tissues, and its high expression was associated with node metastasis, advanced clinical stage, and shorter survival time in patients with cervical cancer. Notably, a negative correlation between miR-302-3p and DCUN1D1 expression in cervical cancer tissues was observed. Taken together, the present study suggests that miR-302-3p serves a suppressive role in cervical cancer metastasis, partly at least, via directly targeting DCUN1D1. Therefore, miR-302-3p/DCUN1D1 may be a potential therapeutic target for cervical cancer treatment.

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“…The proliferation and survival of cells is another important factor to determine the efficiency of cell transplantation. There are reports showing that overexpression of miR124 can inhibit the proliferation of many types of cells, such as glioblastoma cells [ 44 ], cervical carcinoma cells [ 60 ], bladder cancer cells [ 45 ], liver cancer cells [ 61 ], osteosarcoma cells [ 48 ] and breast cancer cells [ 62 ]. While other reports suggested that miR124 promotes the proliferation of neural stem cells (NSCs) by targeting delta-like 4 (DLL4) [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA124 and microRNA21-5p regulate migration, proliferation and differentiation of rat bone marrow mesenchymal stem cells

et al. 2020

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Mesenchymal stem cells (MSCs) are multipotent stromal cells which can be a useful source of cells for the treatment of many diseases, including neurologic diseases. The curative effect of MSCs relies mostly on cell’s capacity of migration, proliferation and differentiation. MicroRNAs (miRNAs) are small non-coding RNAs which play important roles on regulating various cell behaviors. Here, we report that miRNA-124 (miR124) and miRNA-21-5p (miR21-5p) display different regulatory roles on migration, proliferation and neuron differentiation of MSCs. MiR124 was shown greatly promoting MSCs migration and neuronal differentiation. MiR21-5p could significantly enhance the proliferation and neuronal differentiation ability of MSCs. MiR124 and miR21-5p synergistically promote differentiation of MSCs into neurons. Collectively, miR124 and miR21-5p can functionally regulate cell migration, proliferation and neuronal differentiation of MSCs. Therefore, miR124 and miR21-5p may be promising tools to improve transplantation efficiency for neural injury.

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MicroRNA-124 inhibits proliferation, invasion, migration and epithelial-mesenchymal transition of cervical carcinoma cells by targeting astrocyte-elevated gene-1

Cited by 32 publications

References 30 publications

MicroRNA‑124 inhibits cell proliferation, invasion and migration by targeting CAV1 in bladder cancer

MicroRNA‑124 inhibits cell proliferation, invasion and migration by targeting CAV1 in bladder cancer

MicroRNA‑302 inhibits cell migration and invasion in cervical cancer by targeting DCUN1D1

MicroRNA124 and microRNA21-5p regulate migration, proliferation and differentiation of rat bone marrow mesenchymal stem cells

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