MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats

Grace, Peter M.; Strand, Keith A.; Galer, Erika L.; Maier, Steven F.; Watkins, Linda R.

doi:10.1016/j.brainres.2018.04.038

Cited by 26 publications

(20 citation statements)

References 27 publications

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“…Several animal and clinical studies have shown codeine, oxycodone, morphine, and fentanyl may have benefit relieving pain for short term but when used long term lead to glial and immune cells activation, leading to tolerance, allodynia, and hyperalgesia [30,31]. Hydromorphone long-term use has similar effect, opioid neurotoxicity with twitching, myoclonus, unrestful night sleep, and minor agitation.…”

Section: Opioid Analgesicsmentioning

confidence: 99%

“…Hydromorphone long-term use has similar effect, opioid neurotoxicity with twitching, myoclonus, unrestful night sleep, and minor agitation. Activation of glial cell is associated with N-methyl-D-Aspartate (NMDA) receptor and release of amino acid, glutamate which is neuroexcitatory [30,31]. None of the above opioids have NMDA antagonism.…”

Section: Opioid Analgesicsmentioning

confidence: 99%

“…The short-term use of opioids may be useful for acute pain, but the long-term use is associated with activation of glial and immune cells with neuroexcitatory chemicals along with tolerance and hyperalgesia [30,31] (Figure 5).…”

Section: Opioid Usementioning

confidence: 99%

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What Do We Need to Consider for Pain Management?

Chary¹

2021

Pain Management - Practices, Novel Therapies and Bioactives

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Chronic pain in palliative care is viewed as an illness but remains as a subjective symptom. Hence, we must consider genetics, pain experience, coping skills, epigenetic effects, mental health, social determinants of health, interventions, and molecular biology. Acute pain transitions to chronic pain in some individuals following an injury, and there is poor evidence to stop such change. Acute, Chronic, and mixed pain can occur in patients with trauma, cancer, organ failure due to primary illness and other co-morbidities. The response to interventions may include biopsychosocial, non-pharmacological, surgery, radiation, chemotherapy, interventional radiology, pharmacological and depending upon survivorship, consider what is appropriate with peer reviewed medical evidence. Neurobiology is important in relation to physical and psychological issues; it affects an expression of pain. Manageable pain and relief are considered as being Human Right. Lack of adequate knowledge and treatment resources are common for care providers and patients. Cancer and noncancer pain ought to consider collaborating with interdisciplinary palliative approach, palliative care, and end of life care along with acute, chronic, and mixed pain management. Cancer patients with survivorship is increasing and risk management with chemicals, noncancer individuals appear similar. Barriers include health professional education, lack of treatment resources, medical, economic, ethical, and legal reasons. Pain management as an illness, care providers considers patient and family centered approach, useful to the community.

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Section: Opioid Analgesicsmentioning

confidence: 99%

Section: Opioid Analgesicsmentioning

confidence: 99%

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What Do We Need to Consider for Pain Management?

Chary¹

2021

Pain Management - Practices, Novel Therapies and Bioactives

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“…Cancer is a malignant tumor, in which cells become unresponsive to inhibitory cellular growth signals and intrinsic cell replication limits, evade apoptotic signals, leading to tumorigenesis (Ahir et al, 2017). As shown in Table 1, in humans, miR-124 targeting the PIK3CA gene can suppress cell proliferation in hepatocellular carcinoma (Lang and Ling, 2012), targeting HIPK3 can affect oncogenic properties of lung cancer , targeting EphA2 can inhibit cell growth and motility in glioma , targeting integrin subunit alpha 3 (ITGA3) can be a potential target for the treatment of colorectal cancer (Sa et al, 2018), targeting gene RLIP76 can affect proliferation and invasion of malignant melanoma cells (Zhang et al, 2016), targeting Fra-2 suppresses glioma aggressiveness in glioma cells (Luo et al, 2018), and targeting Toll-like receptor signaling can be a valid strategy for reversing neuropathic pain (Grace et al, 2018). MiR-124 also inhibits lung tumorigenesis caused by K-ras mutation and NNK (Jin et al, 2017a).…”

Section: Mir-124 Is Associated With Some Serious Diseasesmentioning

confidence: 99%

MiR-124 involvement of apoptosis, immunity and regulator of diseases

Sun¹,

Huang²,

Yu³

et al. 2020

Afr. J. Biotechnol.

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Most microRNAs (miRNAs) are noncoding, conserved RNA molecules in vertebrates, and their roles are similar and very important. MiRNAs usually have tissue-specific expression, and abnormal levels of miRNAs have been associated with diseases and have been used as disease biomarkers. MiRNAs are widely involved in biological processes by regulating target mRNAs. MiR-124 is one of the best studied miRNAs in organisms. By targeting different mRNAs, miR-124 plays important roles in the central nervous system, cellular infiltration, pathophysiological processes of cardiovascular diseases, inflammation, immunity and tolerance, etc. This review mainly focuses on tissue-specific or abnormal expression of miR-124 as a biomarker and on the ways miR-124 for the treatment of serious diseases such as cancers.

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“…18,58 Up-or down-regulation of miRNAs in the dorsal root ganglion, spinal cord, or brain areas have been observed in inflammatory or neuropathic pain models in animals, and associated with hyperalgesia and allodynia. 35,71 Understanding such mechanisms at the molecular level is likely to hold important clinical implications and provide new targets for the treatments of pain.…”

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confidence: 99%

Epigenetic and miRNA Expression Changes in People with Pain: A Systematic Review

Polli

Godderis

Ghosh

et al. 2020

The Journal of Pain

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Accumulating evidence suggests that epigenetic mechanisms may hold great potential in the field of pain. We systematically reviewed the literature exploring epigenetic mechanisms in people with pain. Four databases have been interrogated: MEDLINE, The Cochrane Central Register of Controlled Trial, Scopus, and Web of Science, following PRISMA guidelines in conducting study selection and assessment. Thirty-seven studies were included. Studies explored epigenetics in conditions such as fibromyalgia, CRPS, neuropathies, or osteoarthritis. Research focussed on genome-wide and gene-specific DNA methylation, and miRNA expression. Bioinformatics analyses exploring miRNAassociated molecular pathways were also performed. Several genes already known for their role in pain (BDNF, HDAC4, PRKG1, IL-17, TNFRSF13B, etc.), and several miRNAs linked to inflammatory regulation, nociceptive signalling and protein kinases functions have been found to differ significantly between people with chronic pain and healthy controls. Although the studies included were crosssectional in nature, and no conclusion on causal links between epigenetic changes and pain could be drawn, we summarised the large amount of data available in literature on the topic, highlighting results that have been replicated by independent investigations. The field of pain epigenetics appears very exciting and has all the potential to lead to remarkable scientific advances. However, high-quality, well-powered, longitudinal studies are warranted. Perspective: Though more high-quality research is needed, available research exploring epigenetic mechanisms or miRNAs in people with pain shows that genes regulating synaptic plasticity and excitability, protein kinases, and elements of the immune system might hold great potential in understanding the pathophysiology of different conditions.

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MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats

Cited by 26 publications

References 27 publications

What Do We Need to Consider for Pain Management?

What Do We Need to Consider for Pain Management?

MiR-124 involvement of apoptosis, immunity and regulator of diseases

Epigenetic and miRNA Expression Changes in People with Pain: A Systematic Review

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