MicroRNA-10b indicates a poor prognosis of non-small cell lung cancer and targets E-cadherin

Zhang, J.; Xu, Luping; Yang, Zuozhang; Lu, Haojie; Hu, Dawei; Li, W.; Zhang, Z.; Liu, B.; Ma, Sai

doi:10.1007/s12094-014-1213-7

Cited by 41 publications

(44 citation statements)

References 23 publications

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“…For example, up-regulation of microRNA-183-3p is a potent prognostic marker for lung adenocarcinoma of female non-smokers [19]. miR-10b expression was an independent prognostic factor in NSCLC patients [20]. Here, the expression of miR-325-3p was significantly decreased in NSCLC tissues.…”

Section: Discussionmentioning

confidence: 84%

Expression of MicroRNA-325-3p and its potential functions by targeting HMGB1 in non-small cell lung cancer

Yao

Zhao

Jin

2015

Biomedicine & Pharmacotherapy

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Section: Discussionmentioning

confidence: 84%

Expression of MicroRNA-325-3p and its potential functions by targeting HMGB1 in non-small cell lung cancer

Yao

Zhao

Jin

2015

Biomedicine & Pharmacotherapy

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“…In gastric cancer, miR-10b expression levels were associated with the size of tumor, Lauren classification, depth of invasion, lymph node and distant metastasis, TNM stage and prognosis (40). Zhang et al (41) reported that the relative expression levels of miR-10b in non-small-cell lung cancer were significantly positively associated with TNM stage and regional lymph node involvement. Kaplan-Meier analysis revealed that patients with increased levels of miR-10b had significantly poorer survival rate than those with lower expression of miR-10b.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-10b inhibits proliferation, migration and invasion in cervical cancer cells via direct targeting of insulin-like growth factor-1 receptor

2017

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Abstract. MicroRNAs are deregulated in numerous types of human cancers and have crucial roles in the carcinogenesis and progression of human cancers. MicroRNA-10b (miR-10b) has been studied in several types of human cancer. However, the expression and roles of miR-10b in cervical cancer remain unknown. In the present study, the expression, functions and molecular mechanisms of miR-10b were explored in cervical cancer. The present data revealed that miR-10b was significantly downregulated in cervical cancer tissues and cell lines. In addition, miR-10b overexpression inhibited the proliferation, migration and invasion of cervical cancer cells, while miR-10b under-expression had the opposite effect. Based on bioinformatics analysis, a luciferase reporter assay and western blot analysis, insulin-like growth factor-1 receptor (IGF-1R) was identified as a direct target of miR-10b in cervical cancer. In addition, IGF-1R small interfering RNA-mediated knockdown of IGF-1R also inhibited the proliferation, migration and invasion of the cervical cancer cells. In conclusion, the present study demonstrated that miR-10b serves an important role in cervical cancer progression by targeting IGF-1R.

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“…Non-small cell lung cancer (NSCLC), including squamous cell carcinoma and adenocarcinoma, accounts for about 85% of lung cancer [5–8]. The five-year overall survival rate of late-stage NSCLC patients is only 5–20% [9–13].…”

Section: Introductionmentioning

confidence: 99%

LncRNA-RMRP Acts as an Oncogene in Lung Cancer

Meng

Ren

et al. 2016

PLoS ONE

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Accumulating studies have demonstrated that long noncoding RNAs (lncRNAs) act a crucial role in the development of tumors. However, the role of lncRNAs in lung cancer remains largely unknown. In this study, we demonstrated that theexpression of RMRP was upregulated in lung adenocarcinoma tissues compared to the matched adjacent normal tissues. Moreover, of 35 lung adenocarcinoma samples, RMRP expression was upregulated in 25 cases (25/35; 71.4%) compared to the adjacent normal tissues. We also showed that RMRP expression was upregulated in lung adenocarcinoma cell lines (A549, SPC-A1, H1299 and H23) compared to the bronchial epithelial cell line (16HBE). Ectopic expression of RMRP promoted lung adenocarcinoma cell proliferation, colony formation and invasion. In addition, overexpression of RMRP inhibited the miR-206 expression in the H1299 cell and increased the KRAS, FMNL2 and SOX9 expression, which were the target genes of miR-206. Re-expression of miR-206 reversed the RMRP-induced the H1299 cell proliferation and migration. Our data proved that RMRP acted as an oncogene LncRNA to promote the expression of KRAS, FMNL2 and SOX9 by inhibiting miR-206 expression in lung cancer. These data suggested that RMRP might serve as a therapeutic target in lung adenocarcinoma.

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MicroRNA-10b indicates a poor prognosis of non-small cell lung cancer and targets E-cadherin

Abstract: Our results indicated that miR-10b expression was an independent prognostic factor in NSCLC patients. Furthermore, miR-10b might be necessary for driving the expression of E-cad in NSCLC.

Cited by 41 publications

References 23 publications

Expression of MicroRNA-325-3p and its potential functions by targeting HMGB1 in non-small cell lung cancer

Expression of MicroRNA-325-3p and its potential functions by targeting HMGB1 in non-small cell lung cancer

MicroRNA-10b inhibits proliferation, migration and invasion in cervical cancer cells via direct targeting of insulin-like growth factor-1 receptor

LncRNA-RMRP Acts as an Oncogene in Lung Cancer

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