2012
DOI: 10.3892/or.2012.1850
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MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells

Abstract: MicroRNAs may function to promote or suppress tumor development, depending on the cellular context. The important role of microRNAs in regulating molecular pathways underlying tumorigenesis has been emphasized in hepatocellular carcinoma (HCC). MicroRNAs regulate gene expression via post-transcriptional mechanisms by inhibiting translation or by degrading mRNA. In this study, we show that microRNA-1 (miR-1) and microRNA-499 (miR-499) are capable of re… Show more

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Cited by 54 publications
(41 citation statements)
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References 33 publications
(43 reference statements)
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“…A change in miR-499 expression might be involved in the modulation of the expression of multiple genes and signaling transduction pathways. Recent studies have identified several target genes of miR-499, such as Drp1 and Ets1 [27, 28]. The tumor suppressor PDCD4 is often down-regulated in several malignancies, and its protein expression could be modulated by miR-21, indicating that PDCD4 down-regulation is a reliable biomarker for early-stage squamous cell esophageal neoplasia [29] In addition, compared to the normal group, NF-κB and TNF-α expression and the apoptosis rates were all increased.…”
Section: Discussionmentioning
confidence: 99%
“…A change in miR-499 expression might be involved in the modulation of the expression of multiple genes and signaling transduction pathways. Recent studies have identified several target genes of miR-499, such as Drp1 and Ets1 [27, 28]. The tumor suppressor PDCD4 is often down-regulated in several malignancies, and its protein expression could be modulated by miR-21, indicating that PDCD4 down-regulation is a reliable biomarker for early-stage squamous cell esophageal neoplasia [29] In addition, compared to the normal group, NF-κB and TNF-α expression and the apoptosis rates were all increased.…”
Section: Discussionmentioning
confidence: 99%
“…It results in the overexpression of certain oncogenes, FoxP1 and MET, as potential targets, thus promoting cell proliferation (Datta et al, 2008). Two other mechanisms of miR-1 action are given by (Wei et al, 2012;Li et al, 2012a). They showed that low levels of miR-1 induce the overexpression of endothelin-1 (ET-1) gene responsible for the degradation of extracellular matrix.…”
Section: Mir-1mentioning
confidence: 99%
“…Ectopic expression of miR193b dramatically suppresses the proliferation, migration, and invasion of hepatocellular carcinoma cells by targeting Ets1 and cyclin D1 (40). Overexpression of miR-1 and miR-499 in hepatocellular carcinoma cells downregulates the Ets1 expression via direct targeting the 3 0 -UTR, resulting in decreased invasion and migration (41). Current approaches for identifying miRNA targets include prediction algorithms and experimental models (42).…”
Section: ) Ets1 Is Also Implicated In Vascularizationmentioning
confidence: 99%