Microreactor technology for synthesis of ethyl methyl oxalate from diethyl oxalate with methanol and its kinectics

Abstract

This study focused on the performances and kinetics of the transesterification reaction of diethyl oxalate with methanol to prepare ethyl methyl oxalate via microreactor technology. The conversion of 79.8% of diethyl oxalate (DEO) and the selectivity of 65.9% of ethyl methyl oxalate (EMO) was obtained under the following optimized conditions: the mole ratio of methanol to diethyl oxalate was 3.3:1, the temperature was 35 C, the K 2 CO 3 catalyst concentration was 15 mg/mL, and the residence time was 2.30 minutes. In the temperature range of 25 C to 38 C, the simplified dynamic model was found to obtain the reaction order (α = 2.30), frequency factor (k 0 = 2.377 × 10 5), and apparent activation energy (E = 31.86 kJ/mol). The macroscopic dynamic equation was derived from the experimental result of the transesterification reaction of two feedstocks, which can be obtained through a series of calculations.

ZnxMg1‐xO Solid Solutions: Efficient Bifunctional Acid‐Base Catalyst for the synthesis of Methyl Ethyl Oxalate from Dimethyl Oxalate and Ethanol

“…Methyl ethyl oxalate (EMO) is a valuable precursor for medicinal and fine chemicals or biological agents, [1] a potential substitute for phosgene, and ethyl halides for carbonylation processes and ethylation due to its unique molecular structure. [2] EMO is usually prepared by the transesterification reaction of DMO and EtOH, [3] which has the advantages of relatively simple operation conditions, mild reaction conditions, and availability of raw materials. [4] Sodium methanol is used as a homogeneous catalyst in the transesterification reaction, which is costeffective and active.…”

Investigation of mixing performance in a semi‐active T‐micromixer actuated by magnetic nanoparticles: Characterization via Villermaux–Dushman reaction

“…Through the past decade, the utilization of micro-scale reactors recognized as microreactors has obtained momentous consideration in the pharmaceutical and chemicals industries. [1][2][3] So, micro-technology is currently applied as a fine area for rapid development in numerous applications due to great mass transfer and efficiency of mixing, high product selectivity, safety proficiency, and lower energy usage. [4][5][6][7][8] Indeed, microreactors perform continuous chemical reactions in a micro-scale channel and provide a highly specific surface.…”

Corrigendum

“…In Ji et al, [ 1 ] an error has been published in the article title. The word “kinectics” should be replaced with “kinetics.” This will read as follows:…”