Microreactor-based chemo-enzymatic ROP-ROMP platform for continuous flow synthesis of bottlebrush polymers

Chen, Kerui; Han, Wei; Hu, Xin; Liu, Yihuan; Hu, Yujing; Zhao, Shufan; Zhu, Ning; Fang, Zheng; Guo, Kai

doi:10.1016/j.cej.2022.135284

Cited by 9 publications

(9 citation statements)

References 81 publications

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Section: Continuous Flow Biochemical Catalysis To Biodegradable Polymersmentioning

confidence: 99%

Microreactor-Based Green Synthetic Platform for Flow Synthesis of Biodegradable Polymers

Hu,

Feng,

et al. 2024

Ind. Eng. Chem. Res.

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Green synthetic strategies to biodegradable polymers have been paid much attention in the background of global attention to sustainable development. Bio- and organocatalyses for ring-opening polymerizations of cyclic monomers offer metal-free biodegradable polymers under mild conditions. With the benefits of a huge surface-to-volume ratio and flow characteristic, a microreactor exhibits unique advantages that cannot be had in a traditional batch reactor. The combination of flow chemistry and bio/organocatalysis provides a green synthetic platform for fast, efficient, and scalable generation of biodegradable polyesters and polycarbonates. This review summarizes ring-opening polymerizations of lactones, lactides, and carbonates by continuous flow biocatalysis, organocatalysis, and biochemical catalysis. Accelerated apparent polymerization rates, improved control of molecular weights and polydispersities, higher end group fidelities, and novel degradable polymeric materials with tunable properties were achieved by using a microreactor-based green synthetic platform. The challenges and opportunities are proposed with the aim to advance the development of the green synthesis and application of sustainable polymers.

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Section: Continuous Flow Biochemical Catalysis To Biodegradable Polymersmentioning

confidence: 99%

Microreactor-Based Green Synthetic Platform for Flow Synthesis of Biodegradable Polymers

Hu,

Feng,

et al. 2024

Ind. Eng. Chem. Res.

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“…As the research continued, more different types of biocatalytic reactions were carried out in microreactors, and the applications became more and more diverse. [68][69][70][71] Figure 8A gives a few landmarks during the development of the microreactor biocatalysis field.…”

Section: Biocatalysismentioning

confidence: 99%

“…As early as the beginning of the 20th century, many scientists began to associate trypsin and microreactors for use in protein decomposition. As the research continued, more different types of biocatalytic reactions were carried out in microreactors, and the applications became more and more diverse [68–71] . Figure 8A gives a few landmarks during the development of the microreactor biocatalysis field.…”

Section: Emerging Trendsmentioning

confidence: 99%

Microreactor Technology: Identifying Focus Fields and Emerging Trends by Using CiteSpace II

2022

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Microreactors have gained widespread attention from academia and industrial researchers due to their exceptionally fast mass and heat transfer and flexible control. In this work, CiteSpace software was used to systematically analyze the relevant literature to gain a comprehensively understand on the research status of microreactors in various fields. The results show that the research depth and application scope of microreactors are continuing to expand. The top 10 most popular research fields are photochemistry, pharmaceutical intermediates, multistep flow synthesis, mass transfer, computational fluid dynamics, μ-TAS (micro total analysis system), nanoparticles, biocatalysis, hydrogen production, and solid-supported reagents. The evolution trends of current focus areas are examined, including photochemistry, mass transfer, biocatalysis and hydrogen production and their milestone literature is analyzed in detail. This article demonstrates the development of different fields of microreactors technology and highlights the unending opportunities and challenges offered by this fascinating technology.

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“…Recent studies on the polymerization under continuousflow conditions have shown their significant advantages compared to the batch process: scalability of photomediated processes; [30][31][32] increased heat and mass transfer properties, 31,33 especially under conditions of dispersion polymerization; 22,34 increased light irradiation efficiencies; 35 unprecedentedly high conversions achieved in a short time; 19,23,32,34,[36][37][38][39] narrower molecular weight distribution; 23,34 simplification of multistage syntheses by using a series or parallel connection of several reactors; 20,31,[39][40][41][42] automation capability. 43 Most of these advantages arise from the ability to precisely control reaction parameters (temperature, reaction time) in a small volume.…”

Section: Introductionmentioning

confidence: 99%

High-molecular weight bottlebrushes via continuous flow photoiniferter polymerization of macromonomers

Sivokhin¹,

Orekhov²,

Казанцев³

et al. 2023

Polym. Chem.

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Microreactor-based chemo-enzymatic ROP-ROMP platform for continuous flow synthesis of bottlebrush polymers

Cited by 9 publications

References 81 publications

Microreactor-Based Green Synthetic Platform for Flow Synthesis of Biodegradable Polymers

Microreactor-Based Green Synthetic Platform for Flow Synthesis of Biodegradable Polymers

Microreactor Technology: Identifying Focus Fields and Emerging Trends by Using CiteSpace II

High-molecular weight bottlebrushes via continuous flow photoiniferter polymerization of macromonomers

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