Micropump and sample-injector for integrated chemical analyzing systems

Shoji, Shuichi; Nakagawa, Shigeru; Esashi, Masayoshi

doi:10.1016/0924-4247(90)85036-4

Cited by 133 publications

(41 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Peristaltic pumps using glass as a diaphragm material as well as this study reported by Shoji et al [43] and Smits et al [44] require large diaphragm diameter (centimeter order) due to small deformability of normal thickness glass. This fact makes the system large and f sp small.…”

Section: Performance Comparison With Other Micropumps On Chipmentioning

confidence: 96%

A Peristaltic Pump Integrated on a 100% Glass Microchip Using Computer Controlled Piezoelectric Actuators

Tanaka¹

2014

Micromachines

View full text Add to dashboard Cite

Lab-on-a-chip technology is promising for the miniaturization of chemistry, biochemistry, and/or biology researchers looking to exploit the advantages of a microspace. To manipulate fluid on a microchip, on-chip pumps are indispensable. To date, there have been several types of on-chip pumps including pneumatic, electroactive, and magnetically driven. However these pumps introduce polymers, metals, and/or silicon to the microchip, and these materials have several disadvantages, including chemical or physical instability, or an inherent optical detection limit. To overcome/avoid these issues, glass has been one of the most commonly utilized materials for the production of multi-purpose integrated chemical systems. However, glass is very rigid, and it is difficult to incorporate pumps onto glass microchips. This paper reports the use of a very flexible, ultra-thin glass sheet (minimum thickness of a few micrometers) to realize a pump installed on an entirely glass-based microchip. The pump is a peristaltic-type, composed of four serial valves sealing a cavity with two penetrate holes using ultra-thin glass sheet. By this pump, an on-chip circulating flow was demonstrated by directly observing fluid flow, visualized via polystyrene tracking particles. The flow rate was proportional to the pumping frequency, with a maximum flow rate of approximately 0.80 μL/min. This on-chip pump could likely be utilized in a wide range of applications which require the stability of a glass microchip.

show abstract

Section: Performance Comparison With Other Micropumps On Chipmentioning

confidence: 96%

A Peristaltic Pump Integrated on a 100% Glass Microchip Using Computer Controlled Piezoelectric Actuators

Tanaka¹

2014

Micromachines

View full text Add to dashboard Cite

show abstract

“…The use of piezoelectric stacks to actuate a micropump has previously been demonstrated by Shoji et al [3]. In this implementation, micropumps capable of non-pulsatile liquid flow and controllable flow rates were integrated on a silicon wafer for use in chemical analyzing systems.…”

Section: Pump Actuator Designmentioning

confidence: 99%

“…A variety of intriguing microcomponents have been developed to control the movement of fluids, including elements based on acoustic, centrifugal and electromagnetic forces; electroosmotic and electrophoretic effects; micromechanical and pneumatically powered components; and vapor bubbles [1][2][3][4][5][6][7][8][9][10][11][12][13]. One of the most promising approaches to developing microfluidics components is the use of printing and molding techniques applied to soft polymeric materials, particularly poly(dimethylsiloxane) (PDMS) [14,15].…”

Section: Introductionmentioning

confidence: 99%

Hybrid macro–micro fluidics system for a chip-based biosensor

Tamanaha¹,

Whitman

Colton

2002

J. Micromech. Microeng.

View full text Add to dashboard Cite

We describe the engineering of a hybrid fluidics platform for a chip-based biosensor system that combines high-performance microfluidics components with powerful, yet compact, millimeter-scale pump and valve actuators. The microfluidics system includes channels, valveless diffuser-based pumps, and pinch-valves that are cast into a poly(dimethylsiloxane) (PDMS) membrane and packaged along with the sensor chip into a palm-sized plastic cartridge. The microfluidics are driven by pump and valve actuators contained in an external unit (with a volume ∼30 cm 3 ) that interfaces kinematically with the PDMS microelements on the cartridge. The pump actuator is a simple-lever, flexure-hinge displacement amplifier that increases the motion of a piezoelectric stack. The valve actuators are an array of cantilevers operated by shape memory alloy wires. All components can be fabricated without the need for complex lithography or micromachining, and can be used with fluids containing micron-sized particulates. Prototypes have been modeled and tested to ensure the delivery of microliter volumes of fluid and the even dispersion of reagents over the chip sensing elements. With this hybrid approach to the fluidics system, the biochemical assay benefits from the many advantages of microfluidics yet we avoid the complexity and unknown reliability of immature microactuator technologies.

show abstract

“…Since then research in this area has undergone an enormous growth and many different microfluidic devices has been developed, which include valves, pumps, flowsensors, and fluidic mixers as well as chemical and biological sensors [5]. Resent work is mostly focused on integrating several devices on a single substrate, the eventual aim being development of an on-chip chemical analysis system [5,6].…”

Section: Chapter II Literature Surveymentioning

confidence: 99%