Microporous PDMAEMA‐based stimuli‐responsive hydrogel and its application in drug release

Abstract

The microporous hydrogels (Pn-Cm gels) composed of poly(dimethylaminoethyl methacrylate) and carboxymethylchitosan were synthesized in situ radical polymerization by using nano g-Fe 2 O 3 particles as pore-agent. The microporous structure formed through eliminating the Fe 2 O 3 particles was designed to achieve a faster response rate and better drug loading effect. Comparing to the neat gels, Pn-Cm gels exhibit deteriorative mechanical properties with the increased pores, while the gels still keep the elastic network structure which could bear some degree of tensile and compression deformation. Meantime, Pn-Cm gels show similar temperature and pH double responsiveness with same isoelectric point shrink as that of neat gels, the swelling ability decreases slightly, and the deswelling rate increases with the increase of pores. Moreover, the 5-fluorouracil was used as a target drug to explore the potential of this gel applied as drug-release system. For Pn-Cm gels, the more pores and carboxymethyl chitosan inside the gels are beneficial to the drug loading, all gels show a burst release of drug, being followed by a slow and sustained release with different rate. Comprehensively, the Pn-Cm gels exhibit a better sustained release effect in the simulated stomach condition (pH 5 2.1), the related release mechanism could be interpreted by the superposition of Fickian diffusion.

An improved method in fabrication of smart dual-responsive nanogels for controlled release of doxorubicin and curcumin in HT-29 colon cancer cells

“…1 b). A signal at 1169 cm −1 was attributed to the stretching vibration of the C-O moiety of the DMAEMA copolymer [ 46 ]. Additionally, the strong peaks around 2926 and 1386 cm −1 are related to the aliphatic C-H stretching and bending mode, respectively.…”

Recent progress of microfluidic chips in immunoassay

“…Hydrogel has become one of the matrix materials of microfluidic chips (Liu M. et al, 2017;Yang F. et al, 2018;Jing et al, 2019;Mofazzal Jahromi et al, 2019;Nielsen et al, 2020), which usually have a hydrophilic porous structure, and its porous structure is filled with water molecules, allowing biomacromolecules to pass through (Lee et al, 2014;Chen et al, 2016;Liu M. et al, 2017;Chen et al, 2017;Xu et al, 2019;Huang et al, 2020;Vera et al, 2021).…”

Development of a Soft Actuator from Fast Swelling Macroporous PNIPAM Gels for Smart Braille Device Applications in Haptic Technology

“…PNIPAM gels are commonly used for drug delivery, , dosimeter, , and biosensing applications. Few studies have demonstrated that it can also be used for soft-actuation purposes. , A PNIPAM gel shows several key characteristics suitable for development of a smart braille tablet.…”