Microplastics released from food containers can suppress lysosomal activity in mouse macrophages

Deng, Jingyu; Ibrahim, M. S.; Tan, Li Yang; Yeo, Xin Yi; Lee, Yong An; Park, Sung Jin; Wüstefeld, Torsten; Park, June-Woo; Jung, Sangyong; Cho, Nam‐Joon

doi:10.1016/j.jhazmat.2022.128980

Cited by 61 publications

(15 citation statements)

References 60 publications

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“…The lysosomal activity was dramatically reduced by nano-PET particles; chronic modification of lysosomal activity and cellular homeostasis results in tissue degeneration and cellular damage. 159 MALT1 expression was elevated in mouse lung tissue following co-exposure to HDM (house dust mites) and MNPs. Histamine-induced endothelial permeability and IgE-dependent mast cell cytokine production are mediated by MALT1, which is expressed in lymphoid, mast, and endothelial cells.…”

Section: Interaction With the Circulatory Systemmentioning

confidence: 99%

“…155 The cytotoxic effect of MNPs has been confirmed on numerous cell lines, for example, lung cells, 32 intestinal cells, 156,157 and many others. Cationic polystyrene nanoplastics (60 nm) were proven to affect cell viability and enhance inflammatory gene expression in gastric cell lines, 158 macrophage 159 cell lines, and epithelial cells. 160 The bioavailability of polystyrene MNPs in rat mammalian models was shown to be about 4% in the blood, bone marrow, liver, and spleen.…”

Section: Potential Impact Of Mnps and Co-pollutants On Human Healthmentioning

confidence: 99%

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Journey of micronanoplastics with blood components

Rajendran,

Chandrasekaran

2023

RSC Adv.

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Section: Interaction With the Circulatory Systemmentioning

confidence: 99%

Section: Potential Impact Of Mnps and Co-pollutants On Human Healthmentioning

confidence: 99%

Journey of micronanoplastics with blood components

Rajendran,

Chandrasekaran

2023

RSC Adv.

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“…The direct damage caused by MPs to lysosomes is reflected in the decrease of lysosomal hydrolase activity, the change of lysosomal pH value and the dysfunction of autophagy. Studies have reported that MPs accumulated in macrophages interact with key components of lysosomes, such as hydrolases or proton pumps, resulting in a decrease in hydrolase activity (Deng et al, 2022). Experiments in macrophages and microglia have shown that MPs inhibit lysosomal phagocytosis by altering the ability of lysosomes to maintain acidic pH.…”

Section: The Lysosomalmentioning

confidence: 99%

Research progress on the cellular toxicity caused by microplastics and nanoplastics

Yang

et al. 2023

J of Applied Toxicology

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Microplastics (MPs) are plastic particles of a diameter of less than 5 mm and a major carrier of pollution. In accordance with its diameter range, MPs can be divided into microplastics (100–5 mm) and nanoplastics (<100 nm). In recent years, in addition to the impact of MPs on the environment, the ways in which MPs affect the body has also attracted continuous attention. However, relevant studies on the cytotoxicity of MPs are not comprehensive. Based on the current research, this paper summarizes four main cytotoxic mechanisms of MPs, inducing oxidative stress, damaging cell membrane organelles, inducing immune response, and genotoxicity. Generally, MPs cause cytotoxicity such as oxidative stress, damage to cell membranes and organelles, activation of immune responses, and genotoxicity through mechanical damage or induction of cells to produce reactive oxygen species. Understanding these toxic mechanisms is helpful for the evaluation and prevention of human toxicity of MPs. This paper also analyzes the limitations of current research and prospects for future research into cellular MPs, with the aim of providing a scientific basis and reference for further research into the toxic mechanism of MPs.

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“…The wide usage of plastic as packaging also increases the risk of MP exposure by migrating MP from package to food. Moreover, processed packaged foods widely consumed during the COVID-19 period ( Oliveira et al, 2021 ) increase the risk of MP exposure ( Deng et al, 2022 ). Packing food with plastic or composite materials, including plastic, is a standard food preservation method.…”

Section: Introductionmentioning

confidence: 99%

Microplastic contamination in canned fish sold in Türkiye

Gündoğdu

Köşker

2023

PeerJ

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The presence of microplastics (MPs) in processed seafood is a growing concern. In this study, 33 different canned fish brands belonging to seven producers were purchased from the Turkish market and investigated. MPs composition, possible sources, and potential intake were assessed. Light microscopy was used to quantify potential MPs, and micro-Raman microscopy was used to identify the polymer types. The results showed that all the samples had at least one MPs particle, and fragments were the most abundant (57.3%) shape of MPs. Polyolefin (21.88%) was the most common polymer type. The results showed that packaging and the production processes are the main possible sources of MPs. Human intake estimation risk is relatively lower since canned fish consumption is relatively low. The findings suggest that the risk related to MPs in canned fish should be considered one of the components of food safety management systems.

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Microplastics released from food containers can suppress lysosomal activity in mouse macrophages

Cited by 61 publications

References 60 publications

Journey of micronanoplastics with blood components

Journey of micronanoplastics with blood components

Research progress on the cellular toxicity caused by microplastics and nanoplastics

Microplastic contamination in canned fish sold in Türkiye

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