Microplastics induced histopathological lesions in some tissues of tilapia (Oreochromis niloticus) early juveniles

Hamed, Mohamed; Soliman, Hatem; Badrey, Ahmed E. A.; Osman, Alaa G. M.

doi:10.1016/j.tice.2021.101512

Cited by 57 publications

(23 citation statements)

References 37 publications

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“…With MPs and NPs treatment, it was observed that carp treated at a concentration of 100 mg/L of macroplastics showed several histopathological changes, including necrosis, spongiosis, degeneration, and edema. These ndings agree with other studies(Hamed et al 2021b) that reported several changes in the brain based on histopathology, including tissue degeneration, vacuolar degeneration, edema, necrosis, and hemorrhage in tilapia after exposure to microplastic. Similar effects were reported in gold sh (Carassius auratus) exposed to virgin microplastics and zebra sh (Danio rerio) larvae exposed to pristine low-density polyethylene fragments(Romano et al 2020;Karami et al 2017) In the optic tectum, exposure to 100 mg/L of microplastic for 15 days resulted in pathology that was more severe.…”

supporting

confidence: 93%

Neurotoxic effects of different sizes of plastics (Nano, Micro, and Macro) on juvenile common carp (Cyprinus carpio)

Hamed

Martyniuk

Naguib

et al. 2022

Preprint

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Using common carp as a model, we assessed the effects of polyethylene (PE) plastics on brain. We measured activity of acetylcholinesterase (AChE), monoamine oxidase (MAO), and the content of nitric oxide (NO) in carp brain following exposure to 100 mg/L of either macroplastics (MaP), microplastics (MPs) or nanoplastic (NPs) for 15 days compared to an unexposed group. Following exposure, each biochemical biomarker was reduced 30-40%, with a higher magnitude of change corresponding to the smaller size of the particles (NPs>MPs>MaPs). In the carp tectum, exposure for 15 days to plastic particles caused varying degrees of necrosis, fibrosis, changes in blood capillaries, tissue detachment, edema, degenerated connective tissues, and necrosis in large cerebellar neurons and ganglion cells. In the carp retina, there was evidence for necrosis, degeneration, vacuolation, and curvature in the inner layer. Here we provide evidence that exposure to plastic particles can be associated with neurotoxicity in common carp.

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supporting

confidence: 93%

Neurotoxic effects of different sizes of plastics (Nano, Micro, and Macro) on juvenile common carp (Cyprinus carpio)

Hamed

Martyniuk

Naguib

et al. 2022

Preprint

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“…Exposure of fish to water contaminants results in histopathological damage, indicating health deterioration and organs' dysfunction. Copper‐ and MPs‐induced intestinal lesions have been previously reported in fish (Al‐Bairuty et al, 2013; Hamed et al, 2021; Maharajan et al, 2016; Pedà et al, 2016). The pigments observed in the intestine of the fish of the Cu and Cu‐MPVC treatments might be related to the presence of copper since they were not observed in the MPVC group.…”

Section: Discussionmentioning

confidence: 87%

Histopathological damage and stress‐ and immune‐related genes' expression in the intestine of common carp, Cyprinus carpio exposed to copper and polyvinyl chloride microparticle

et al. 2021

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The present study aimed at assessing the singular and combined effects of water copper and polyvinyl chloride microplastic (MPVC) on intestinal copper accumulation, histopathological damage, and stress‐/immune‐related genes' expression in common carp, Cyprinus carpio. Four groups of fish were maintained in triplicate: control (kept in clean water), Cu (exposed to 0.25 mg/L of copper), MPVC (exposed to 0.5 mg/L of MPVC), and Cu‐MPVC (exposed to 0.25 mg/L of copper + 0.5 mg/L of MPVC). After 14‐day exposure, the fish of Cu and Cu‐MPVC treatments exhibited significantly higher intestinal copper contents, compared to the fish of control and MPVC treatments. In this regard, the Cu‐MPVC fish had significantly higher copper content than the Cu fish. Exposure to copper and/or MPVC significantly upregulated the intestinal heat shock protein 70 (hsp70), cytochrome P450 family 1 subfamily A member 1 (cyp1a1), lysozyme (lys), defensin (def), mucin 2 (muc2), and mucin 5 (muc5) expression. The highest expression of hsp70, cyp1a1, lys, and def was related to Cu‐MPVC treatment; whereas, the highest expression of muc2 and muc5 was observed in Cu and MPVC treatments. Exposure to copper and/or MPVC induced intestinal damage, which Cu‐MPVC fish exhibited the highest severity. The present study revealed that exposure to copper and/or MPVC causes intestinal histopathological damage and upregulation in stress‐ and immune‐related genes' expression. The most serious effects were observed in Cu‐MPVC treatment that might be due to additive effects of copper and MPVC and/or higher copper accumulation in this treatment.

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“…Freshwater fishes are affected by plastic materials derived from industrial activity, agricultural applications, and daily consumer activities; this leads to water pollution with toxic macro-, micro- and nanoplastics and this can negatively affect both aquatic organisms and humans ( Hamed et al, 2019 , 2020 , 2021a , 2021b , 2022 ; Sayed et al, 2021a , b ).…”

Section: Discussionmentioning

confidence: 99%

Neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp (Cyprinus carpio)

Hamed

Martyniuk

Naguib

et al. 2022

Front. Mol. Neurosci.

Self Cite

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Using common carp as a model, we assessed the effects of polyethylene (PE) plastics on the brain. We measured activity of acetylcholinesterase (AChE), monoamine oxidase (MAO), and the content of nitric oxide (NO) in carp brain following exposure to 100 mg/L of either macroplastics (MaP), microplastics (MPs), or nanoplastic (NPs) for 15 days compared to an unexposed group. Following exposure, each biochemical biomarker was reduced 30–40%, with a higher magnitude of change corresponding to the smaller size of the particles (NPs > MPs > MaPs). In the carp tectum, exposure for 15 days to plastic particles caused varying degrees of necrosis, fibrosis, changes in blood capillaries, tissue detachment, edema, degenerated connective tissues, and necrosis in large cerebellar neurons and ganglion cells. In the carp retina, there was evidence for necrosis, degeneration, vacuolation, and curvature in the inner layer. Here we provide evidence that exposure to plastic particles can be associated with neurotoxicity in common carp.

show abstract

Microplastics induced histopathological lesions in some tissues of tilapia (Oreochromis niloticus) early juveniles

Cited by 57 publications

References 37 publications

Neurotoxic effects of different sizes of plastics (Nano, Micro, and Macro) on juvenile common carp (Cyprinus carpio)

Neurotoxic effects of different sizes of plastics (Nano, Micro, and Macro) on juvenile common carp (Cyprinus carpio)

Histopathological damage and stress‐ and immune‐related genes' expression in the intestine of common carp, Cyprinus carpio exposed to copper and polyvinyl chloride microparticle

Neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp (Cyprinus carpio)

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