Microplastic-contaminated antibiotics as an emerging threat to mammalian liver: enhanced oxidative and inflammatory damages

Fu, Jianxin; Zhang, Lan; Xiang, Keyu; Wang, Guoqing; Chen, Lingxin

doi:10.1039/d2bm02116a

Biomater. Sci.

2023

DOI: 10.1039/d2bm02116a

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Microplastic-contaminated antibiotics as an emerging threat to mammalian liver: enhanced oxidative and inflammatory damages

Jianxin Fu

Lan Zhang

Keyu Xiang

et al.

Abstract: Poor management and disposal of plastic materials and the accumulation of microplatics in environment and foods have been an issue of increasing public concern. Current understanding of the implication of...

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Worker studies suggest unique liver carcinogenicity potential of polyvinyl chloride microplastics

Zarus,

Muianga,

Brenner

et al. 2023

American J Industrial Med

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BackgroundPlastic debris pervades our environment. Some breaks down into microplastics (MPs) that can enter and distribute in living organisms causing effects in multiple target organs. MPs have been demonstrated to harm animals through environmental exposure. Laboratory animal studies are still insufficient to evaluate human impact. And while MPs have been found in human tissues, the health effects at environmental exposure levels are unclear.AimWe reviewed and summarized existing evidence on health effects from occupational exposure to MPs. Additionally, the diverse effects documented for workers were organized by MP type and associated co‐contaminants. Evidence of the unique effects of polyvinyl chloride (PVC) on liver was then highlighted.MethodsWe conducted two stepwise online literature reviews of publications focused on the health risks associated with occupational MP exposures. This information was supplemented with findings from animal studies.ResultsOur analysis focused on 34 published studies on occupational health effects from MP exposure with half involving exposure to PVC and the other half a variety of other MPs to compare. Liver effects following PVC exposure were reported for workers. While PVC exposure causes liver toxicity and increases the risk of liver cancers, including angiosarcomas and hepatocellular carcinomas, the carcinogenic effects of work‐related exposure to other MPs, such as polystyrene and polyethylene, are not well understood.ConclusionThe data supporting liver toxicity are strongest for PVC exposure. Overall, the evidence of liver toxicity from occupational exposure to MPs other than PVC is lacking. The PVC worker data summarized here can be useful in assisting clinicians evaluating exposure histories from PVC exposure and designing future cell, animal, and population exposure‐effect research studies.

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Worker studies suggest unique liver carcinogenicity potential of polyvinyl chloride microplastics

Zarus,

Muianga,

Brenner

et al. 2023

American J Industrial Med

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Chlorella alleviates the intestinal damage of tilapia caused by microplastics

Zheng,

Xiaoxian,

et al. 2024

Chemosphere

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Enhanced hepatotoxicity in zebrafish due to co-exposure of microplastics and sulfamethoxazole: Insights into ROS-mediated MAPK signaling pathway regulation

Xiong,

Zhang,

Shi

et al. 2024

Ecotoxicology and Environmental Safety

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Microplastic-contaminated antibiotics as an emerging threat to mammalian liver: enhanced oxidative and inflammatory damages

Abstract: Poor management and disposal of plastic materials and the accumulation of microplatics in environment and foods have been an issue of increasing public concern. Current understanding of the implication of...

Cited by 5 publications

References 56 publications

Worker studies suggest unique liver carcinogenicity potential of polyvinyl chloride microplastics

Worker studies suggest unique liver carcinogenicity potential of polyvinyl chloride microplastics

Chlorella alleviates the intestinal damage of tilapia caused by microplastics

Enhanced hepatotoxicity in zebrafish due to co-exposure of microplastics and sulfamethoxazole: Insights into ROS-mediated MAPK signaling pathway regulation

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