In this paper, we present a large area nanosecond pulse gas‐liquid diffuse discharge plasma with small flow rate of helium as working gas. The discharge images, the waveforms of pulse voltage & current, the emission spectra, and the gas temperature are measured or calculated. As a energy‐efficient sterilization for sewage, the efficiency of sewage sterilization in both static liquid and flowed liquid are investigated. It is found that an optimal value of helium gas flow rate in the production of reactive oxygen species (OH, O) can be obtained when the He flow rate is 5 ml min−1, under this condition, high inactivation efficiencies of bacteria and fungus can be presented.