2019
DOI: 10.15252/embj.2019102190
|View full text |Cite
|
Sign up to set email alerts
|

Micropeptide CIP 2A‐ BP encoded by LINC 00665 inhibits triple‐negative breast cancer progression

Abstract: TGF-b signaling pathway plays a key role in breast cancer metastasis. Recent studies suggest that TGF-b regulates tumor progression and invasion not only via transcriptional regulation, but also via translational regulation. Using both bioinformatics and experimental tools, we identified a micropeptide CIP2A-BP encoded by LINC00665, whose translation was downregulated by TGF-b in breast cancer cell lines. Using TNBC cell lines, we showed that TGF-b-activated Smad signaling pathway induced the expression of tra… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

4
56
0
1

Year Published

2020
2020
2024
2024

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 170 publications
(71 citation statements)
references
References 54 publications
4
56
0
1
Order By: Relevance
“…According to the evidence provided about the molecular mechanisms of some of these reviewed lncRNAs, they could be druggable targets for small interfering RNAs or antisense oligonucleotides, but this therapy is not yet possible in clinical practice owing to delivery problems, which could be solved by ongoing nanotechnological approaches. Additionally, in a recently opened research line, lncRNAs were regarded as true coding RNAs producing small peptides of less than 100 amino acids, which could be the real effectors of the lncRNAs in the cells and could have profound implications for cancer physiology [193]. These lncRNAs and their derived peptides, which are also putative therapeutic targets to be tested in the next years, can be consulted in the database SmProt [175].…”
Section: Discussionmentioning
confidence: 99%
“…According to the evidence provided about the molecular mechanisms of some of these reviewed lncRNAs, they could be druggable targets for small interfering RNAs or antisense oligonucleotides, but this therapy is not yet possible in clinical practice owing to delivery problems, which could be solved by ongoing nanotechnological approaches. Additionally, in a recently opened research line, lncRNAs were regarded as true coding RNAs producing small peptides of less than 100 amino acids, which could be the real effectors of the lncRNAs in the cells and could have profound implications for cancer physiology [193]. These lncRNAs and their derived peptides, which are also putative therapeutic targets to be tested in the next years, can be consulted in the database SmProt [175].…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies revealed that some transcripts previously classified as lncRNAs encode micropeptides [ 55 , 56 , 57 ]. Micropeptides are polypeptides with a length of <150 amino acids (aa), transcribed from short ORFs (sORFs) [ 58 ].…”
Section: Protein Coding Potentialmentioning
confidence: 99%
“…To date, functional peptides or proteins generated from unconventional regions, including long intergenic non-coding RNAs (LincRNAs), 5′ un-translational region (5'UTR) and circRNAs, have been adequately demonstrated [11][12][13]. We previously reported that open reading frame (ORF) in circRNAs driven by internal ribosomal entry site (IRES) translates functional proteins during glioblastoma tumorigenesis [14,15].…”
Section: Introductionmentioning
confidence: 99%