Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo(ethylene glycol) alkanethiolates

Herbert, Curtis B.; McLernon, Terri L.; Hypolite, Claire L.; Adams, Derek N.; Pikus, Lana; Huang, C. C.; Fields, Gregg B.; Letourneau, Paul C.; Distefano, Mark D.; Hu, Wei Shou

doi:10.1016/s1074-5521(97)90311-2

Cited by 160 publications

(95 citation statements)

References 18 publications

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“…Weber et al [183] grafted carbohydrates onto TiO 2 surfaces for applications in cell recognition, blood coagulation cascade and sialoglycoprotein recognition. Hypolite et al [184] and Herbert et al [185] synthesized bioconjugate molecules bearing both a peptide domain and photoactive group together with benzophenone. The benzophenone derivatives could be linked covalently onto the solid surface by irradiation.…”

Section: Biochemical Modification Of Titanium and Titanium Alloysmentioning

confidence: 99%

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Liu

Chu

Ding

2004

Materials Science and Engineering: R: Reports

3,032

1,477

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Titanium and titanium alloys are widely used in biomedical devices and components, especially as hard tissue replacements as well as in cardiac and cardiovascular applications, because of their desirable properties, such as relatively low modulus, good fatigue strength, formability, machinability, corrosion resistance, and biocompatibility. However, titanium and its alloys cannot meet all of the clinical requirements. Therefore, in order to improve the biological, chemical, and mechanical properties, surface modification is often performed. This article reviews the various surface modification technologies pertaining to titanium and titanium alloys including mechanical treatment, thermal spraying, sol-gel, chemical and electrochemical treatment, and ion implantation from the perspective of biomedical engineering. Recent work has shown that the wear resistance, corrosion resistance, and biological properties of titanium and titanium alloys can be improved selectively using the appropriate surface treatment techniques while the desirable bulk attributes of the materials are retained. The proper surface treatment expands the use of titanium and titanium alloys in the biomedical fields. Some of the recent applications are also discussed in this paper. #

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Section: Biochemical Modification Of Titanium and Titanium Alloysmentioning

confidence: 99%

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Liu

Chu

Ding

2004

Materials Science and Engineering: R: Reports

3,032

1,477

View full text Add to dashboard Cite

show abstract

“…Furthermore, fibronectin gradients generated by microfluidics induce fibroblast haptotaxis towards higher fibronectin concentration; however, the net movement directly correlates with the gradient slope, while the overall rate of migration does not (Rhoads and Guan, 2007). Herbert et al (1997) introduced a method for using photoimmobilization of peptides on self-assembled monolayer, while (Wang et al, 2004) merged electrochemical potential gradients with electrosorption of organothiols. Smith et al (2004) produced surface-bound gradients of fibronectin by the crossdiffusion of inert and reactive functionalized alkanethiols on gold.…”

Section: Defined Gradients Of Ecm Peptides Direct Cell Polarization Amentioning

confidence: 99%

Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location

et al. 2008

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“…CHO cells overexpressing EGF receptor proteins exhibited enhanced growth on higher density (smaller gap) of immobilized EGF. Herbert et al 66 photo-immobilized micropatterns of Arg-Gly Asp (RGD) sequencecontaining oligopeptides on an oligo(ethylene glycol) alkanethiolate SAM. The pattern and amount of immobilized RGD were controlled by manipulating the duration of UV exposure through a photomask, resulting in a surface density gradient of immobilized peptides.…”

Section: Iiic Surface Gradientsmentioning

confidence: 99%

Biology on a Chip: Microfabrication for Studying the Behavior of Cultured Cells

Tourovskaia

Folch

2003

Crit Rev Biomed Eng

173

140

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The ability to culture cells in vitro has revolutionized hypothesis testing in basic cell and molecular biology research and has become a standard methodology in drug screening and toxicology assays. However, the traditional cell culture methodology-consisting essentially of the immersion of a large population of cells in a homogeneous fluid medium-has become increasingly limiting, both from a fundamental point of view (cells in vivo are surrounded by complex spatiotemporal microenvironments) and from a practical perspective (scaling up the number of fluid handling steps and cell manipulations for high-throughput studies in vitro is prohibitively expensive). Micro fabrication technologies have enabled researchers to design, with micrometer control, the biochemical composition and topology of the substrate, the medium composition, as well as the type of neighboring cells surrounding the microenvironment of the cell. In addition, microtechnology is conceptually well suited for the development of fast, low-cost in vitro systems that allow for high-throughput culturing and analysis of cells under large numbers of conditions. Here we review a variety of applications of microfabrication in cell culture studies, with an emphasis on the biology of various cell types.

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Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo(ethylene glycol) alkanethiolates

Cited by 160 publications

References 18 publications

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location

Biology on a Chip: Microfabrication for Studying the Behavior of Cultured Cells

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