Microparticulate Drug Delivery Systems for Chinese Medicines

Wang, Wenping

doi:10.1007/978-981-16-3444-4_9

Cited by 1 publication

(1 citation statement)

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“…These herbs exhibit antibacterial, antiviral, anti-inflammatory, antioxidant, anti-tumor, analgesic, immune-modulating, and tissue-regenerating activities, among others [17,18]. However, due to the standard pharmaceutical procedures utilized in the manufacturing of Chinese medications, there are obstacles in establishing controllable quality, safety, efficiency, and patient compliance in traditional Chinese medicine (TCM) [19]. Yunnan Baiyao (YB), a commercially available herbal preparation, has been used to treat bruises, injuries, and bleeding wounds.…”

Section: Introductionmentioning

confidence: 99%

Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning

Zhou,

Wang,

Gong

et al. 2023

Biomedicines

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In this nanotechnology era, nanostructures play a crucial role in the investigation of novel functional nanomaterials. Complex nanostructures and their corresponding fabrication techniques provide powerful tools for the development of high-performance functional materials. In this study, advanced micro-nanomanufacturing technologies and composite micro-nanostructures were applied to the development of a new type of pharmaceutical formulation, aiming to achieve rapid hemostasis, pain relief, and antimicrobial properties. Briefly, an approach combining a electrohydrodynamic atomization (EHDA) technique and reversed-phase solvent was employed to fabricate a novel beaded nanofiber structure (BNS), consisting of micrometer-sized particles distributed on a nanoscale fiber matrix. Firstly, Zein-loaded Yunnan Baiyao (YB) particles were prepared using the solution electrospraying process. Subsequently, these particles were suspended in a co-solvent solution containing ciprofloxacin (CIP) and hydrophilic polymer polyvinylpyrrolidone (PVP) and electrospun into hybrid structural microfibers using a handheld electrospinning device, forming the EHDA product E3. The fiber-beaded composite morphology of E3 was confirmed through scanning electron microscopy (SEM) images. Fourier-transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) analysis revealed the amorphous state of CIP in the BNS membrane due to the good compatibility between CIP and PVP. The rapid dissolution experiment revealed that E3 exhibits fast disintegration properties and promotes the dissolution of CIP. Moreover, in vitro drug release study demonstrated the complete release of CIP within 1 min. Antibacterial assays showed a significant reduction in the number of adhered bacteria on the BNS, indicating excellent antibacterial performance. Compared with the traditional YB powders consisting of Chinese herbs, the BNS showed a series of advantages for potential wound dressing. These advantages include an improved antibacterial effect, a sustained release of active ingredients from YB, and a convenient wound covering application, which were resulted from the integration of Chinese herbs and Western medicine. This study provides valuable insights for the development of novel multiscale functional micro-/nano-composite materials and pioneers the developments of new types of medicines from the combination of herbal medicines and Western medicines.

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Section: Introductionmentioning

confidence: 99%