Microparticulate Drug Carriers

Juliano, R. L.

doi:10.1007/978-1-4612-5186-6_9

Cited by 4 publications

(3 citation statements)

References 46 publications

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“…Biodegradability and Clearance: Niosome biodegradability and bodily removal may provide difficulties. For these systems to be used safely and to avoid any build up in tissues, these problems must be resolved 68,69 .…”

Section: Challengesmentioning

confidence: 99%

Niosomal Drug Delivery System used in Tuberculosis

Shanker,

Chanana,

Gupta

et al. 2024

J. Drug Delivery Ther.

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Niosomes are artificially manufactured vesicles made of Cholesterol and Non-ionic surfactant. Their capacity to encapsulate a broad variety of pharmaceuticals and shield them from deterioration has piqued interest in drug delivery. Niosomes have demonstrated a possible use in the administration of anti-tuberculosis medications. Worldwide, tuberculosis is a serious public health concern. Even with advances in science and technology, tuberculosis remains a persistent problem.Niosomes can encapsulate anti-TB drugs, protecting them from enzymatic degradation and allowing for sustained release. Research in this field is on-going, with scientists working on optimizing niosomal formulations for tuberculosis treatment. It's important to consult current scientific literature for the latest advancements. Some anti-tubercular drugs face challenges in terms of absorption and bioavailability. Niosomal delivery systems can help address these issues. While niosomal drug delivery systems show promise, it's crucial to note that they are still an area of active research and specific formulations and protocols may vary. Patients should always consult with their healthcare providers for the most appropriate and up-to-date treatment options for tuberculosis. Niosomes can encapsulate both hydrophilic and lipophilic drugs, offering advantages such as increased drug stability, prolonged circulation time, controlled release, and targeted delivery. They have applications in various fields including pharmaceuticals, cosmetics, and agriculture. Keywords: Tuberculosis, Niosomes, Drug delivery system

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Section: Challengesmentioning

confidence: 99%

Niosomal Drug Delivery System used in Tuberculosis

Shanker,

Chanana,

Gupta

et al. 2024

J. Drug Delivery Ther.

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“…But their clinical application is hindered due to poor bioavailability, instability during storage and after administration, and also some side effects during the application. To overcome these problems, niosomes may serve as good carriers for the delivery of various protein and peptide drugs, and also show good performance in vaccine formulation and application [70,71].…”

Section: The Application Of the Niosomes In Chemical Drugs Proteimentioning

confidence: 99%

Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

et al. 2019

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Non-Ionic surfactant based vesicles, also known as niosomes, have attracted much attention in pharmaceutical fields due to their excellent behavior in encapsulating both hydrophilic and hydrophobic agents. In recent years, it has been discovered that these vesicles can improve the bioavailability of drugs, and may function as a new strategy for delivering several typical of therapeutic agents, such as chemical drugs, protein drugs and gene materials with low toxicity and desired targeting efficiency. Compared with liposomes, niosomes are much more stable during the formulation process and storage. The required pharmacokinetic properties can be achieved by optimizing components or by surface modification. This novel delivery system is also easy to prepare and scale up with low production costs. In this paper, we summarize the structure, components, formulation methods, quality control of niosome and its applications in chemical drugs, protein drugs and gene delivery.

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“…RES recognition is considerably lowered for particles less than ca. 200 nm and with appropriately modified surfaces. − …”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of a Unimolecular Polymeric Micelle and Its Degradation Products

Frauchiger

et al. 2001

Biomacromolecules

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The cytotoxicity of a unimolecular polymeric micelle (1) and its degradation products was assessed by cell proliferation and viability with L929 mouse areolar/adipose fibroblasts. Polymer 1 and poly(ethylene glycol) (PEG) were diluted to concentrations from 10(-4) to 10(-6) M in culture media, whereas the degradation products were diluted to concentrations (10(-4) to 10(-6) M) that would theoretically occur upon degradation of polymer 1. The polymer degradation products that were evaluated included mucic acid, hexanoic acid, 1,1,1-tris(4-hydroxyphenyl)ethane (THPE),2,3,4,5-tetrakis-hexanoyloxy-hexanedioic acid or MA(hex), Core(hex), and PEG5, which is PEG of molecular weight 5000. Cells exposed to polymer 1 proliferated at the same rate as cells grown in polymer-free or PEG5-containing solutions up to 36 h. In both the polymer 1 and PEG5 solutions, cytotoxicity was not observed at any concentration (up to 10(-4) M) as indicated by cell attachment, growth, and morphology. Fibroblasts exposed to the degradation products fared as well as fibroblasts in contact with polymer 1 and PEG5, except for cells exposed to the highest concentration (10(-4) M) of THPE.

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Microparticulate Drug Carriers

Cited by 4 publications

References 46 publications

Niosomal Drug Delivery System used in Tuberculosis

Niosomal Drug Delivery System used in Tuberculosis

Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

Cytotoxicity of a Unimolecular Polymeric Micelle and Its Degradation Products

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