Microparticulate and nanotechnology mediated drug delivery system for the delivery of herbal extracts

Dubey, Sunil Kumar; Parab, Shraddha; Achalla, Pavan Kumar; Narwaria, Avinash; Sharma, Swapnil; Gowda, B.H. Jaswanth; Kesharwani, Prashant

doi:10.1080/09205063.2022.2065408

Cited by 25 publications

(6 citation statements)

References 87 publications

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“…Another important issue is that phytoconstituents are highly sensitive to some environmental and physical factors, e.g., pH, oxygen, heat, etc. [52]. In addition, herbal medicine has low solubility, stability, and bioavailability [51,53].…”

Section: Importance Of Novel Drug Delivery Systems Development For He...mentioning

confidence: 99%

“…Today, the drug delivery system used to administer herbal medicine lacks efficacy and has side effects from various compounds [50]. To add to that, novel drug delivery systems in herbal medicine should protect phytoconstituents from internal and external conditions [52]. Recently, nanotechnology-based herbal drug formulations have shown promising results in developing biocompatible, biodegradable drug delivery systems (lipids, polymers, and nanoemulsions), which increase the solubility, stability, bioavailability, and pharmacological activity of herbals [51,54,55].…”

Section: Importance Of Novel Drug Delivery Systems Development For He...mentioning

confidence: 99%

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Development of Essential Oil Delivery Systems by ‘Click Chemistry’ Methods: Possible Ways to Manage Duchenne Muscular Dystrophy

Kaspute,

Arunagiri,

Alexander

et al. 2023

Materials

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Recently, rare diseases have received attention due to the need for improvement in diagnosed patients’ and their families’ lives. Duchenne muscular dystrophy (DMD) is a rare, severe, progressive, muscle-wasting disease. Today, the therapeutic standard for treating DMD is corticosteroids, which cause serious adverse side effects. Nutraceuticals, e.g., herbal extracts or essential oils (EOs), are possible active substances to develop new drug delivery systems to improve DMD patients’ lives. New drug delivery systems lead to new drug effects, improved safety and accuracy, and new therapies for rare diseases. Herbal extracts and EOs combined with click chemistry can lead to the development of safer treatments for DMD. In this review, we focus on the need for novel drug delivery systems using EOs as the therapy for DMD and the potential use of click chemistry for drug delivery systems. New EO complex drug delivery systems may offer a new approach for improving muscle conditions and mental health issues associated with DMD. However, further research should identify the potential of these systems in the context of DMD. In this review, we discuss possibilities for applying EOs to DMD before implementing expensive research in a theoretical way.

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Section: Importance Of Novel Drug Delivery Systems Development For He...mentioning

confidence: 99%

Section: Importance Of Novel Drug Delivery Systems Development For He...mentioning

confidence: 99%

Development of Essential Oil Delivery Systems by ‘Click Chemistry’ Methods: Possible Ways to Manage Duchenne Muscular Dystrophy

Kaspute,

Arunagiri,

Alexander

et al. 2023

Materials

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show abstract

“…Conventional drug delivery systems, such as oral and injectable systems, have certain shortcomings to some extent, such as poor bioavailability and imprecise targeting [89][90][91]. The ideal drug delivery system would have a microporous shape, no influence on the efficacy of the drug itself, few side effects and precisely controlled release [92][93][94]. Microsphere-based scaffolds have been proposed as an excellent drug delivery system because of their ability to encapsulate a certain amount of drug components, multiple routes of administration and prevent inactivation of drugs [95][96][97].…”

Section: Drug Deliverymentioning

confidence: 99%

Progress in microsphere-based scaffolds in bone/cartilage tissue engineering

Pan,

Su,

Yao

2023

Biomed. Mater.

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Bone/cartilage repair and regeneration have been popular and difficult issues in medical research. Tissue engineering is rapidly evolving to provide new solutions to this problem, and the key point is to design the appropriate scaffold biomaterial. In recent years, microsphere-based scaffolds have been considered suitable scaffold materials for bone/cartilage injury repair because microporous structures can form more internal space for better cell proliferation and other cellular activities, and these composite scaffolds can provide physical/chemical signals for neotissue formation with higher efficiency. This paper reviews the research progress of microsphere-based scaffolds in bone/chondral tissue engineering, briefly introduces types of microspheres made from polymer, inorganic and composite materials, discusses the preparation methods of microspheres and the exploration of suitable microsphere pore size in bone and cartilage tissue engineering, and finally details the application of microsphere-based scaffolds in biomimetic scaffolds, cell proliferation and drug delivery systems.

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“…In conclusion, there are various phases involved in creating nanoparticles or encapsulating extracts with prebiotic potential, including choosing the right components, adjusting the formulation, and characterising the finished product. These procedures are essential for ensuring the manufacturing of prebioticpotential nanoparticles or encapsulated extracts that are secure, efficient, and high-quality 83 .…”

Section: Characterizationmentioning

confidence: 99%

Metal-Infused Polyphenol-enriched Phyto-fabricated Nanoparticles: an In-depth Review of their Potent Prebiotic Properties

Reddy,

Aluri,

A. R. Shashikala

2023

jmmf

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In light of its potential health benefits, including as improved gut health and management of the gut microbiota, herbal extracts have witnessed a major increase in demand as prebiotics in recent years. Many studies have demonstrated that polyphenolrich herbal extracts can work as prebiotics by encouraging the growth of beneficial gut flora. Unfortunately, the limited solubility and stability of these herbal extracts, as well as their susceptibility to breakdown in the gastrointestinal system, can limited their bioavailability and efficiency. To address these limitations, the integration of metal nanoparticles has emerged as a promising strategy for the efficient delivery of herbal extracts, affording heightened bioavailability and precise targeting of the gut microbiota. In this paper, we present current breakthrough in metal infused nanoparticle-based assessment of herbal extracts as efficient prebiotics, with an emphasis on formulation, characterization, and biological activity. The integration of metal nanoparticles into polyphenol-rich herbal extracts represents a cutting-edge approach to enhancing the prebiotic properties of these compounds. Metal-infused polyphenol-enriched phyto-fabricated nanoparticles hold great promise for improving gut health and modulating the gut microbiota, offering innovative solutions to address the limitations associated with traditional polyphenol delivery. Furthermore, extracts of polyphenol-rich medicinal herbs such as rosehip flower, hibiscus flower, mango bark, bamboo stem, green tea, pomegranate, and dhataki flower have been investigated to assess the viability of employing these phyto generated metal infused nanoparticles as a potential prebiotic

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Microparticulate and nanotechnology mediated drug delivery system for the delivery of herbal extracts

Cited by 25 publications

References 87 publications

Development of Essential Oil Delivery Systems by ‘Click Chemistry’ Methods: Possible Ways to Manage Duchenne Muscular Dystrophy

Development of Essential Oil Delivery Systems by ‘Click Chemistry’ Methods: Possible Ways to Manage Duchenne Muscular Dystrophy

Progress in microsphere-based scaffolds in bone/cartilage tissue engineering

Metal-Infused Polyphenol-enriched Phyto-fabricated Nanoparticles: an In-depth Review of their Potent Prebiotic Properties

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