Microparticles as controlled drug delivery carrier for the treatment of ulcerative colitis: A brief review

Abstract

Ulcerative colitis is the chronic relapsing multifactorial gastrointestinal inflammatory bowel disease, which is characterized by bloody or mucus diarrhea, tenesmus, bowel dystension, anemia. The annual incidence of ulcerative colitis in Asia, North America and Europe was found to be 6.3, 19.2 and 24.3 per 100,000 person-years. The major challenge in the treatment of ulcerative colitis is appropriate local targeting and drug related side-effects. To overcome these challenges, microparticulate systems seem to be a promising approach for controlled and sustained drug release after oral administration. The main goal of this article is to explore the role of microparticles in ulcerative colitis for the appropriate targeting of drugs to colon. There are different approaches which have been studied over the last decade, including prodrugs, polymeric approach, time released system, pH sensitive system, which show the site specific drug delivery to colon. Among these approaches, microparticulate drug delivery system has been gaining an immense importance for local targeting of drug to colon at a controlled and sustained rate. Combined approaches such as pH dependent and time dependent system provide the maximum release of drug into colon via oral route. This article embraces briefly about pathophysiology, challenges and polymeric approaches mainly multiparticulate systems for site specific drug delivery to colon in sustained and controlled manner so that drug related side-effects by reducing dosage frequency can be minimized.

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“…Colon Associated Diseases: 17,18,19,20 Pseudomembranous colitis, also known as antibiotic-associated diarrhoea (AAD), is an infection of the colon often caused by the bacterium clostridium difficile and characterized by offensive-smelling diarrhoea, fever, and abdominal pain Angiodysplasia Tortuous dilution of sub-mucosal and mucosal blood vessels in the cecum or right colon, usually after the age of 60. Angiodysplasia is a small vascular malformation of the gut.…”

A Review on Pulsatile System Considering Anti Hypertensive Drugs

“…solid, liquid or gel). When release is desired, an electric potential is applied between an anode membrane and a cathode, the gold membrane anode dissolves within [10][11][12][13][14][15][16][17][18][19][20] seconds and allows the drug in the reservoir to be released. This electric potential causes oxidation of the anode material to form a soluble complex with the electrolytes which then dissolves allowing release of the drug.…”

Synthetic Biodegradable Microparticle and Nanoparticle Vaccines against the Respiratory Syncytial Virus

“…Generally speaking, nanoparticles are defined as solid particles ranging in size from 10 to <1000 nm [16], and MPs as particles ranging in size from 1 to <1000 µm [32]. The particles are made of biodegradable materials that allow the release of the antigen as the particle degrades over time.…”