Microparticle formation of sodium cellulose sulfate using supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer

Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

“…Additionally, the micronization process shifted toward the growth process, and so, larger particles were produced. 27 Previous researchers have also reported similar results. 28,29 effect of concentration of solution As indicated in Figures 4 and 5, the concentration of solution had a slight effect on particle size; hence, the higher the concentration of solution, the smaller the particle size.…”

Supercritical fluid assisted production of micrometric powders of the labile trypsin and chitosan/trypsin composite microparticles

“…Obviously, larger trypsin particles were obtained at higher protein concentration. This change in particle size is usually observed in SAA/SAA-HCM process (Adami et al, 2009;Reverchon and Antonacci, 2006;Wang et al, 2010), because the viscosity and surface tension of the solution increased at higher solution concentration, which weakened the atomization. Compared with Fig.…”

“…As widely discussed in previous work (Cai et al, 2008;Wang et al, 2010), a key factor determining the efficiency of SAA-HCM process is the solubilization of SC-CO 2 in the liquid solution inside the mixer, which is related to the solvent itself, mixer temperature and pressure. When using water as the liquid solvent, the operating conditions of the solution-CO 2 mixture would always fall into the two-phase region as the solubility of CO 2 is quite limited.…”

“…An orifice plate is designed as the cavitation generator, and the cavitation phenomenon can strengthen mass transfer in heterogeneous systems to achieve near thermodynamic equilibrium within a shorter time, which may be more favorable for process of protein solutions. So far, SAA and SAA-HCM have been applied mainly in the micronization of non-protein substances, including inorganic salts (Reverchon and Spada, 2004a), polymers (Wang et al, 2010) and antibiotics (Reverchon and Spada, 2004b), with controlled particle size distributions from either organic solvents or aqueous solutions. Meanwhile, only few proteins have been dealt with SAA/SAA-HCM process from aqueous solutions.…”

Production of encapsulated quercetin particles using supercritical fluid technologies

“…Precipitation kinetics of PMMA submicrometric particles using supercritical atomization process were studied in the work of Wu et al [6]. Supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer was used by Wang et al, to produce sodium cellulose sulphate microparticles with well-defined spherical morphologies and controlled particle size distributions in aqueous solution [7]. In some cases, emulsions and suspensions are treated by supercritical assisted processes, such as the rotenone coprecipitation with biodegradable polymers studied by Martin et al [8], and the encapsulation of 1-monoacylglycerols in an hydrophilic carrier by supercritical assisted atomization of emulsions reported in the work of Ševčíková et al [9] Supercritical assisted atomization technology is also applicable to obtain products for medical purposes, such as the production of composite polymer-Fe3O4 microparticles [10], and the production of nanostructured chitosan-hydroxyapatite microparticles [11], as presented by Reverchon et al In this work, PGSS-drying has been employed as drying method.…”