Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation

Abstract

Microparticle (MP)-associated tissue factor (TF) activity in plasma might play a role in human disseminated intravascular coagulation (DIC). The aim of this study was to compare MP-TF activity between non-DIC and DIC groups. Ten clinically healthy beagles and 26 diseased dogs were enrolled. The proportion of dogs with increased MP-TF activity was significantly higher in the DIC group than the non-DIC group (P=0.014). MP-TF activity in the DIC group was significantly higher than the non-DIC group (P=0.021). MP-TF activity positively correlated with plasma D-dimer concentration (r=0.42, P=0.034). Moreover, MP-TF activity was decreased by the time of recovery in some dogs with DIC. Larger prospective studies are warranted to assess its value as a diagnostic and prognostic biomarker in DIC.

Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases

“…However, several articles have been published in veterinary medicine on the role of microparticles, especially platelet-derived microparticles, in coagulation and cardiovascular diseases. 94 , 96 …”

“…However, several articles have been published in veterinary medicine on the role of microparticles, especially plateletderived microparticles, in coagulation and cardiovascular diseases. 94,96 After release by donor cells into the extracellular space, EVs reach their target cells. Many EVs are taken up by the recipient cells and degraded by their lysosomal system; in others, the EV contents induce phenotypic changes in the recipient cell.…”