Microorganisms-extracellular matrix interactions: relation to pathogenicity - review

Carneiro, Célia Regina Whitaker; Lopes, José Daniel

doi:10.1590/s0074-02761991000700007

Cited by 3 publications

(2 citation statements)

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“…The initial hypothesis was that the presence of S. mansoni granulomas would facilitate E. histolytica infection, since there would be a change in the hepatic microenvironment and exposure of the extracellular matrix and its components 3 . Moreover, collagen resulting from S. mansoni granulomas might serve as adhesion sites for subsequent amoebic colonization.…”

Section: Discussionmentioning

confidence: 99%

Morbidity due to Schistosoma mansoni - Entamoeba histolytica coinfection in hamsters (Mesocricetus auratus)

Dolabella

Coelho

Borçari

et al. 2007

Rev. Soc. Bras. Med. Trop.

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Section: Discussionmentioning

confidence: 99%

Morbidity due to Schistosoma mansoni - Entamoeba histolytica coinfection in hamsters (Mesocricetus auratus)

Dolabella

Coelho

Borçari

et al. 2007

Rev. Soc. Bras. Med. Trop.

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“…The extracellular matrix (ECM) occupies the space between animal cells and is composed of secreted proteoglycans and non-proteoglycan polysaccharides or proteins like collagens, fibronectin, and laminin [20,21]. These macromolecules influence adhesion, migration, proliferation, and differentiation of eukaryotic cells [22], and they serve also as substrate for the attachment and internalization of pathogenic microorganisms [23,24]. ECM- and plasminogen-binding properties have also been reported for a limited number of Mycoplasma species like M. penetrans [25], M. hyopneumoniae [26,27], M. bovis [28] and M. gallisepticum [29-31].…”

Section: Introductionmentioning

confidence: 99%

Factors influencing the cell adhesion and invasion capacity of Mycoplasma gallisepticum

et al. 2013

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BackgroundThe cell invasiveness of Mycoplasma gallisepticum, the causative agent of respiratory disease in chickens and infectious sinusitis in turkeys, may be a substantial factor in the well-known chronicity of these diseases and in the systemic spread of infection. To date, not much is known about the host factors and mechanisms involved in promotion or obstruction of M. gallisepticum adherence and/or cell invasion.In the current study, the influence of extracellular matrix (ECM) proteins such as fibronectin, collagen type IV and heparin, as well as plasminogen/plasmin, on the adhesion and cell invasion levels of M. gallisepticum to chicken erythrocytes and HeLa cells was investigated in vitro. Two strains, Rhigh and Rlow, which differ in their adhesion and invasion capacity, were analyzed by applying a modified gentamicin invasion assay. Binding of selected ECM molecules to M. gallisepticum was proven by Western blot analysis.ResultsCollagen type IV, fibronectin, and plasminogen exerted positive effects on adhesion and cell invasion of M. gallisepticum, with varying degrees, depending on the strain used. Especially strain Rhigh, with its highly reduced cell adhesion and invasion capabilities seemed to profit from the addition of plasminogen. Western and dot blot analyses showed that Rhigh as well as Rlow are able to adsorb horse fibronectin and plasminogen present in the growth medium. Depletion of HeLa cell membranes from cholesterol resulted in increased adhesion, but decreased cell invasion.ConclusionECM molecules seem to play a supportive role in the adhesion/cell invasion process of M. gallisepticum. Cholesterol depletion known to affect lipid rafts on the host cell surface had contrary effects on cell adherence and cell invasion of M. gallisepticum.

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Interleukin‐13 in the skin and interferon‐γ in the liver are key players in immune protection in human schistosomiasis

Dessein

Kouriba

Eboumbou

et al. 2004

Immunological Reviews

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Microorganisms-extracellular matrix interactions: relation to pathogenicity - review

Cited by 3 publications

References 0 publications

Morbidity due to Schistosoma mansoni - Entamoeba histolytica coinfection in hamsters (Mesocricetus auratus)

Morbidity due to Schistosoma mansoni - Entamoeba histolytica coinfection in hamsters (Mesocricetus auratus)

Factors influencing the cell adhesion and invasion capacity of Mycoplasma gallisepticum

Interleukin‐13 in the skin and interferon‐γ in the liver are key players in immune protection in human schistosomiasis

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