Microorganisms as a source of tyrosinase inhibitors: a review

Fernandes, Michelle S.; Kerkar, Savita

doi:10.1007/s13213-017-1261-7

Cited by 37 publications

(28 citation statements)

References 122 publications

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“…A competitive inhibitor can bind to a free enzyme and prevents substrate binding to the enzyme active site. Regarding the property that tyrosinase is a metalloenzyme, copper chelators such as many aromatic acids, phenolic and poly-phenolic compounds, a few non-aromatic compounds, can inhibit tyrosinase competitively by mimicking the substrate of tyrosinase 52 , 60 . Recently, it was found that d -tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity, competitively 113 .…”

Section: Tyrosinase Inhibitionmentioning

confidence: 99%

A comprehensive review on tyrosinase inhibitors

Zolghadri

Bahrami

Khan³

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

752

471

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Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture industries as antibrowning compounds. For this purpose, many natural, semi-synthetic and synthetic inhibitors have been developed by different screening methods to date. This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.

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Section: Tyrosinase Inhibitionmentioning

confidence: 99%

A comprehensive review on tyrosinase inhibitors

Zolghadri

Bahrami

Khan³

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

752

471

View full text Add to dashboard Cite

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“…It is generally believed that fungal laccases as such from Botrytis cinerea detoxify phenolic compounds (e.g., the phytoalexin resveratrol) by oxidative transformation to di-, oligo-or polymers which are less bioavailable and bioactive [20]. On the other hand, the first enzymatic oxidation products from polyphenolics are high-reactive quinones which can rapidly react with amino acids, peptides and proteins by Michael-type additions [43]. In the case of enzymes this will lead to their inhibition [9,44].…”

Section: Enyzmatic Oxidationsmentioning

confidence: 99%

Wine Phenolic Compounds: Antimicrobial Properties against Yeasts, Lactic Acid and Acetic Acid Bacteria

et al. 2017

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Abstract:Microorganisms play an important role in the conversion of grape juice into wine. Yeasts belonging the genus Saccharomyces are mainly responsible for the production of ethanol, but members of other genera are known as producers of off-flavors, e.g., volatile phenols. Lactic acid and acetic acid bacteria also occur regularly in must and wine. They are mostly undesirable due to their capacity to produce wine-spoiling compounds (acetic acid, biogenic amines, N-heterocycles, diacetyl, etc.). In conventional winemaking, additions of sulfite or lysozyme are used to inhibit growth of spoilage microorganisms. However, there is increasing concern about the health risks connected with these enological additives and high interest in finding alternatives. Phenols are naturally occurring compounds in grapes and wine and are well known for their antimicrobial and health-promoting activities. In this study, we tested a selection of phenolic compounds for their effect on growth and viability of wine-associated yeasts and bacteria. Our investigations confirmed the antimicrobial activities of ferulic acid and resveratrol described in previous studies. In addition, we found syringaldehyde highly efficient against wine-spoiling bacteria at concentrations of 250-1000 µg/mL. The promising bioactive activities of this aromatic aldehyde and its potential for winemaking deserves further research.

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“…Tyrosinase inhibition is achieved by the chelation of copper ions. Commercially available tyrosinase inhibitors act as copper ion chelators (Fernandes & Kerkar, 2017).…”

Section: Skin Hyperpigmentationmentioning

confidence: 99%

Review on druggable targets of key age‐associated properties regulated by therapeutic agents

Sudhakaran

Pillai

2020

Chem Biol Drug Des

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Aging is a biological process which accounts for the deterioration of effective physiological functions. The malfunctioning of vital organ systems leads to the onset of neurodegenerative, cardiovascular, and immunomodulatory diseases in the elder population. Age‐dependent mitochondrial dysfunctions trigger the production of reactive oxygen species, which serve as a major contributing factor for the onset of age‐associated diseases. The increasing burden of age‐related pathologies explicates the relevance of identifying novel therapeutic agents with enhanced potency and bioavailability. Key information on the biological mechanisms of significant age‐related diseases aids in understanding relevant druggable targets essential for the initiation and progression of the disease. This review provides detailed insights into the druggable targets of key anti‐aging properties of therapeutic agents such as anti‐oxidant, immunomodulation, cardioprotection, anti‐melanogenic, and anti‐elastase properties. This information aids in the development of novel therapeutic agents/ supplements with enhanced efficacy.

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Microorganisms as a source of tyrosinase inhibitors: a review

Cited by 37 publications

References 122 publications

A comprehensive review on tyrosinase inhibitors

A comprehensive review on tyrosinase inhibitors

Wine Phenolic Compounds: Antimicrobial Properties against Yeasts, Lactic Acid and Acetic Acid Bacteria

Review on druggable targets of key age‐associated properties regulated by therapeutic agents

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