Microorganisms as a Potential Source of Molecules to Control Trypanosomatid Diseases

Chan-Bacab, Manuel Jesús; Reyes-Estebanez, María Manuela; Camacho-Chab, Juan Carlos; Ortega-Morales, Benjamín Otto

doi:10.3390/molecules26051388

Cited by 7 publications

(4 citation statements)

References 124 publications

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“…The most common approaches to obtain new biosynthetic agents are based on searches in isolated habitats, and that impose conditions for this microbe to evolve genetically and possess unique chemical structures with possible bioactivity (Fig. 2) [28][29][30].…”

Section: Developmentmentioning

confidence: 99%

Frontiers in the search for new antimicrobials: new perspectives

Silva¹,

Martins²,

Evangelho³

et al. 2023

Braz. J. Develop.

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Infections caused by bacteria and fungi resistant to antimicrobials are one of the main public health problems in the world. These microorganisms are associated with high rates of morbidity and mortality and also with high hospital costs. Their emergence and spread are closely related to the excessive and inappropriate use of antimicrobials in medical and veterinary practices and in animal production. For the treatment of Candida spp. there are few classes of antifungals available for treatment, the classes being: azole derivatives, polyenes and echinocandins. The class of azoles includes imidazole derivatives (ketoconazole, miconazole, clotrimazole), triazole derivatives (fluconazole, itraconazole and voriconazole) and posaconazole. These drugs can be used for topical us as well as in the treatment and prophylaxis of invasive infections. The wide use of these drugs has led to a strong selection of strains resistant to them, which is increasingly growing. The need to produce new antimicrobial drugs requires different strategies, among which we highlight the importance of bioprospecting for secondary metabolites of environmental bacteria and fungi with potential antimicrobial activity.

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Section: Developmentmentioning

confidence: 99%

Frontiers in the search for new antimicrobials: new perspectives

Silva¹,

Martins²,

Evangelho³

et al. 2023

Braz. J. Develop.

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“…Microorganisms might be a potential source of molecules to control parasitic infections such as Chagas disease [ 8 ], which is a trypanosomiasis that is considered neglected by the World Health Organization (WHO). This condition affects over six million people worldwide, mainly in Latin America [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Saturated Iso-Type Fatty Acids from the Marine Bacterium Mesoflavibacter zeaxanthinifaciens with Anti-Trypanosomal Potential

Santos Ferreira,

de Castro Levatti,

Santa Cruz

et al. 2024

Pharmaceuticals

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Chagas disease is a Neglected Tropical Disease with limited and ineffective therapy. In a search for new anti-trypanosomal compounds, we investigated the potential of the metabolites from the bacteria living in the corals and sediments of the southeastern Brazilian coast. Three corals, Tubastraea coccinea, Mussismilia hispida, Madracis decactis, and sediments yielded 11 bacterial strains that were fully identified by MALDI-ToF/MS or gene sequencing, resulting in six genera—Vibrio, Shewanella, Mesoflavibacter, Halomonas, Bacillus, and Alteromonas. To conduct this study, EtOAc extracts were prepared and tested against Trypanosoma cruzi. The crude extracts showed IC50 values ranging from 15 to 51 μg/mL against the trypomastigotes. The bacterium Mesoflavibacter zeaxanthinifaciens was selected for fractionation, resulting in an active fraction (FII) with IC50 values of 17.7 μg/mL and 23.8 μg/mL against the trypomastigotes and amastigotes, respectively, with neither mammalian cytotoxicity nor hemolytic activity. Using an NMR and ESI-HRMS analysis, the FII revealed the presence of unsaturated iso-type fatty acids. Its lethal action was investigated, leading to a protein spectral profile of the parasite altered after treatment. The FII also induced a rapid permeabilization of the plasma membrane of the parasite, leading to cell death. These findings demonstrate that these unsaturated iso-type fatty acids are possible new hits against T. cruzi.

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“…Over the last decade, several reviews have reported the bioactivity of natural products against protozoan neglected diseases [ 7 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. However, natural products described in these reviews were obtained from different sources, including microbial [ 19 ], endophytes [ 20 ] and other fungi [ 21 ], marine [ 22 ], or animal origins [ 23 , 24 ]. Some reviews also present a mix of natural compounds origins [ 7 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Plant Terpenoids as Hit Compounds against Trypanosomiasis

et al. 2022

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Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites Trypanosoma brucei and Trypanosoma cruzi, respectively. These diseases were circumscribed to South American and African countries in the past. However, human migration, military interventions, and climate changes have had an important effect on their worldwide propagation, particularly Chagas disease. Currently, the treatment of trypanosomiasis is not ideal, becoming a challenge in poor populations with limited resources. Exploring natural products from higher plants remains a valuable approach to find new hits and enlarge the pipeline of new drugs against protozoal human infections. This review covers the recent studies (2016–2021) on plant terpenoids, and their semi-synthetic derivatives, which have shown promising in vitro and in vivo activities against Trypanosoma parasites.

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Microorganisms as a Potential Source of Molecules to Control Trypanosomatid Diseases

Cited by 7 publications

References 124 publications

Frontiers in the search for new antimicrobials: new perspectives

Frontiers in the search for new antimicrobials: new perspectives

Saturated Iso-Type Fatty Acids from the Marine Bacterium Mesoflavibacter zeaxanthinifaciens with Anti-Trypanosomal Potential

Plant Terpenoids as Hit Compounds against Trypanosomiasis

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