Micronutrients in Maternal and Infant Health: Where We Are and Where We Should Go

Yu, Yunxian

doi:10.3390/nu15092192

Cited by 2 publications

(3 citation statements)

References 20 publications

(20 reference statements)

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“…Recent research offers evidence that maternal VDR gene polymorphisms likely play a pivotal role by influencing the biological activity of vitamin D in certain unfavorable pregnancy outcomes [62,63]. The VDR gene encodes the vitamin D3 receptor, which belongs to the nuclear hormone receptor superfamily and plays a pivotal role in mediating the biological effects of vitamin D [74].…”

Section: Discussionmentioning

confidence: 99%

“…The increasing prevalence of HDP is a significant factor contributing to almost 20% of worldwide maternal mortality, elevating the associated risks for maternal, child, and long-term cardiovascular health [59][60][61]. The existing research has predominantly focused on exploring the relationship between vitamin D status, gene variations in the vitamin D metabolic pathway, and HDP, frequently neglecting possible interactions among these factors [62,63]. For instance, Si and colleagues investigated the interplay between maternal SNPs in genes related to the vitamin D metabolic pathway (GC, CYP24A1, CYP3A4, CYP27B1, LRP2, and VDR) and vitamin D levels during pregnancy, examining their impact on gestational blood pressure and HDP development.…”

Section: Other Maternal Outcomesmentioning

confidence: 99%

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Exploring Gene–Diet Interactions for Mother–Child Health: A Systematic Review of Epidemiological Studies

Favara,

Maugeri,

Magnano San Lio

et al. 2024

Nutrients

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Background: Maternal–child health suggests the critical impact of maternal nutrition during the pre-conception and gestational periods, with some genetic variants also playing a significant role. Our systematic review provides an overview of epidemiological studies exploring the interactions between genetic variants, maternal dietary habits, and neonatal and/or maternal pregnancy outcomes. Methods: From its inception until June 2023, we conducted a comprehensive literature search on PubMed, Embase, and Web of Science databases. Results: On a total of 29 epidemiological studies, 11 studies were conducted to explore the interplay between genetic variants and dietary factors, focusing on the risks associated with gestational diabetes mellitus, hypertensive disorders of pregnancy, recurrent spontaneous abortion, recurrent pregnancy loss, iron deficiency anemia, and gestational weight gain. Concerning neonatal outcomes, six studies investigated the interplay between genetic variants, dietary factors, and anthropometric measures, while eight studies delved into abnormal embryonic development, two studies focused on preterm birth, and two studies explored other neonatal outcomes. Conclusions: Deeply understanding gene–diet interactions could be useful in developing highly personalized approaches to maternal and child nutrition, as well as in exploring the potential implications in disease prevention and the promotion of the long-term well-being of both mothers and their offspring.

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Section: Discussionmentioning

confidence: 99%

Section: Other Maternal Outcomesmentioning

confidence: 99%

Exploring Gene–Diet Interactions for Mother–Child Health: A Systematic Review of Epidemiological Studies

Favara,

Maugeri,

Magnano San Lio

et al. 2024

Nutrients

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“…[ 6 8 ] Moreover, a healthy dietary habit can provide the mothers with sufficient micronutrients. [ 9 ]…”

Section: Introductionmentioning

confidence: 99%

The Assessment of Neonatal Anthropometric Indices Association with Umbilical Cord Blood Zinc and Magnesium Levels

Amini,

Mousavi,

Vard

et al. 2023

Advanced Biomedical Research

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Background: The present research aims to find the association between neonatal anthropometric parameters and zinc and magnesium concentration in cord blood. Materials and Methods: The current cross-sectional report is a sub-study from the “PERSIAN Birth Cohort Study” conducted on 112 pairs of mother-neonate referring to the index hospitals for giving birth to their children during 2018–19. Umbilical cord blood was collected at delivery for the measurement of zinc and magnesium. Anthropometric indices were measured in standard protocols. Validated questionnaires were used for maternal diet in different trimesters. Dietary patterns were acquired based on exploratory factor analysis. Results: The birth weight was reversely correlated with zinc concentration (r = -0.249, P-value = 0.008); however, the other anthropometric parameters did not show any association with zinc levels (P-value > 0.05). Similar evaluations for magnesium revealed no association between any of the anthropometric indices and this micronutrient agent (P-value > 0.05). Further evaluations represented insignificant differences in both zinc (P-value = 0.51) and magnesium levels (P-value = 0.49) between those with normal versus low birth weight. There was a negative association between the Western dietary pattern in the first trimester of pregnancy and cord blood zinc concentration (β (SE) = -0.21 (0.10); P = 0.026); while healthy and traditional dietary patterns in second and third trimesters were positively related to cord zinc concentration (all P < 0.05). Conclusion: This research did not document a positive statistical association of cord blood zinc and magnesium with birth weight. The association of maternal Western dietary patterns with lower cord blood zinc levels highlights the importance of healthy nutritional habits in pregnancy.

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Micronutrients in Maternal and Infant Health: Where We Are and Where We Should Go

Abstract: The first 1000 days of life are defined by the World Health Organization as a “window of opportunity” for a person’s growth and development, and nutrition is particularly important during this time window [...]

Cited by 2 publications

References 20 publications

Exploring Gene–Diet Interactions for Mother–Child Health: A Systematic Review of Epidemiological Studies

Exploring Gene–Diet Interactions for Mother–Child Health: A Systematic Review of Epidemiological Studies

The Assessment of Neonatal Anthropometric Indices Association with Umbilical Cord Blood Zinc and Magnesium Levels

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