Micronutrients: current issues for HIV care providers

Tang, Alice; Lanzillotti, Jane; Hendricks, Kristy; Gerrior, Jül; Ghosh, Mayurika; Woods, Margo N.; Wanke, Christine

doi:10.1097/01.aids.0000171398.77500.a9

Cited by 42 publications

(35 citation statements)

References 104 publications

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“…Among these micronutrients vitamin A, Vitamin C, selenium, Zinc, Calcium and iron are moderately affected (Tang et al, 2005). In a chronic disease like HIV/AIDS the Quality Of Life (QOL) of the patients form an important aspect.…”

Section: Introductionmentioning

confidence: 99%

Nutritional Status and Quality of Life of Women with HIV/AIDS

S.¹

2012

American Journal of Infectious Diseases

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Problem statement:HIV infection is a multisystem disorder which causes chronic infections that lead to profound immune-suppression. Women have always been a vulnerable section of the society. They are doubly vulnerable due to the HIV and malnutrition vicious cycle, which may affect their Quality Of Life (QOL). There are different literature reviews which suggest undernutrition, wasting due to HIV but it is important to know whether this under-nutrition affects their Quality Of Life (QOL) of these vulnerable women. Approach: This cross sectional study recruited female patients on antiretroviral therapy. Weight, height, grip strength, Tricep Skin Fold (TSF) and Mid Upper Arm Circumference (MUAC) were measured. Nutrient intake was calculated by 24 h recall and food frequency questionnaire. WHO QOL-HIV BREF was used to assess QOL. Results: Among 55 patients, 32 (58.2%), 23 (41.8%) were asymptomatic and symptomatic respectively. The mean adequacies of energy and protein for all the subjects were 57.56 ± 21.89, 61.27 ± 28.50 percent respectively. The Body Mass Index (BMI) of the symptomatic were significantly (p = 0.009) lower than the asymptomatic subjects, the mean being 19.84 ± 3.6 (kg/m²), with 27.3% having BMI < 18.5 (kg/m²). The mean TSF, MUAC, grip strength and hemoglobin level were 10.66 ± 4.36 mm, 23.72 ± 3.43 cm, 16.12 ± 5.03 kg force and 10.8 ± 1.3g/dl respectively. The scores of QOL were correlated positively with all the parameters of nutritional status. Grip strength and hemoglobin level were significantly correlated (p = 0.01) with the scores of four and five domains of QOL respectively. Conclusion: Dietary intake was inadequate, which affected the nutritional status. Conservation of muscle mass and maintenance of hemoglobin levels may improve QOL in HIV infected women. Thus there is a need for nutritional counseling and other nutritional intervention.

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Section: Introductionmentioning

confidence: 99%

Nutritional Status and Quality of Life of Women with HIV/AIDS

S.¹

2012

American Journal of Infectious Diseases

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“…Recent review articles have described macronutrients in HIV-infected adults (10) and children (11), micronutrient deficiencies (19,20) and intervention trials (21) in HIV-positive persons not receiving HAART, and nutritional needs and management in HIV-positive persons receiving HAART (22,23). Although some researchers have recently called for micronutrient supplements as an adjunct therapy to HAART (19,24), no review articles, to our knowledge, have summarized studies describing micronutrient concentrations and micronutrient intervention trials in HIV-positive persons receiving HAART.…”

Section: Introductionmentioning

confidence: 99%

Micronutrients in HIV-positive persons receiving highly active antiretroviral therapy

Drain

Kupka

Mugusi

et al. 2007

The American Journal of Clinical Nutrition

137

109

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“…Thus, treating the patients with antioxidants since early stages of the disease is believed to be beneficial argued by Tang et al (2005), Gil et al (2005a) and Hurwitz et al (2007).…”

Section: Factors To Be Considered During Antiviral Treatment Concernimentioning

confidence: 99%

“…For example, it is difficult to ascertain true micronutrient status, measures of intake are imprecise, recommendations for desired intakes vary, and surrogate markers of OS and strategy to valuate its references and deviation differ from one author to another. For HIV-infected individuals with adequate viral suppression, but inadequate CD4+ cell counts, micronutrients could play a role in boosting the immune response demostrated by Valko et al (2007) and Tang et al (2005).…”

Section: Factors To Be Considered During Antiviral Treatment Concernimentioning

confidence: 99%

Oxidative Stress Associated to Disease Progression and Toxicity during Antiretroviral Therapy in Human Immunodeficiency Virus Infection

Valle¹,

Hernández²,

Ávila³

2013

JVM

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Oxidative stress condition arises during imbalance between oxidants and antioxidants of diverse origin damaging both structure and function of tissues. Oxidative stress has been suggested as a cofactor during Human Immunodeficiency Virus Infection course involved in many aspects of disease pathogenesis as viral replication, inflammatory responses, decreased immune cell proliferation, loss of immune function, cellular apoptosis, chronic weight loss, and increased sensitivity to drug toxicity.In this review, we provide an overview of the oxidative metabolism pathways involved in HIV infection, examine the potential impact of antirretroviral toxicity on oxidative damage and argue how the response contribute to co-morbidities. Moreover, we also discuss recent reports from observational and interventional studies which have led to an increasing interest in the possible benefits of micronutrient supplementation as a cost-effective strategy for improving oxidative and nutritional status in HIV infection. The general strategy and combination of these interventions represent an important complementary deal for HIV infection treatment in the era of high active antiretroviral therapy.

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Micronutrients: current issues for HIV care providers

Cited by 42 publications

References 104 publications

Nutritional Status and Quality of Life of Women with HIV/AIDS

Nutritional Status and Quality of Life of Women with HIV/AIDS

Micronutrients in HIV-positive persons receiving highly active antiretroviral therapy

Oxidative Stress Associated to Disease Progression and Toxicity during Antiretroviral Therapy in Human Immunodeficiency Virus Infection

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