Micronutrients: A Double-Edged Sword in Microbe-Induced Gastric Carcinogenesis

Noto, Jennifer M.; Peek, Richard M.

doi:10.1016/j.trecan.2015.07.002

Cited by 6 publications

(5 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies using pharmacological approaches to modulate inflammation or knock-out animal models of infection lacking cytokine receptors have highlighted the crucial importance of pro-inflammatory responses in promoting H. pylori -associated gastric carcinogenesis (Waghray et al, 2010 ; Huang et al, 2013 ; Oshima et al, 2014 ). This may point towards the importance of protective natural dietary compounds and micronutrients in reducing inflammation and preventing carcinogenesis (Wang, 2014 ; Noto and Peek, 2015 ; Zitvogel et al, 2017 ). Thus, natural anti-inflammatory compounds may hold considerable promise in preventing H. pylori -associated gastric pathologies (Wang, 2014 ).…”

Section: Discussion-potential Therapeutic Strategiesmentioning

confidence: 99%

Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression

Díaz

Valenzuela-Valderrama

et al. 2018

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) infection is the major risk factor associated with the development of gastric cancer. The transition from normal mucosa to non-atrophic gastritis, triggered primarily by H. pylori infection, initiates precancerous lesions which may then progress to atrophic gastritis and intestinal metaplasia. Further progression to dysplasia and gastric cancer is generally believed to be attributable to processes that no longer require the presence of H. pylori. The responses that develop upon H. pylori infection are directly mediated through the action of bacterial virulence factors, which drive the initial events associated with transformation of infected gastric cells. Besides genetic and to date poorly defined environmental factors, alterations in gastric cell stress-adaptive mechanisms due to H. pylori appear to be crucial during chronic infection and gastric disease progression. Firstly, H. pylori infection promotes gastric cell death and reduced epithelial cell turnover in the majority of infected cells, resulting in primary tissue lesions associated with an initial inflammatory response. However, in the remaining gastric cell population, adaptive responses are induced that increase cell survival and proliferation, resulting in the acquisition of potentially malignant characteristics that may lead to precancerous gastric lesions. Thus, deregulation of these intrinsic survival-related responses to H. pylori infection emerge as potential culprits in promoting disease progression. This review will highlight the most relevant cellular adaptive mechanisms triggered upon H. pylori infection, including endoplasmic reticulum stress and the unfolded protein response, autophagy, oxidative stress, and inflammation, together with a subsequent discussion on how these factors may participate in the progression of a precancerous lesion. Finally, this review will shed light on how these mechanisms may be exploited as pharmacological targets, in the perspective of opening up new therapeutic alternatives for non-invasive risk control in gastric cancer.

show abstract

Section: Discussion-potential Therapeutic Strategiesmentioning

confidence: 99%

Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression

Díaz

Valenzuela-Valderrama

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Diet and chronic diseases have complex interactions since human diets are considered as a 'double-edged sword' that carry both beneficial and harmful substances (10) . Nutrients in the food prevent cancer through inhibiting cell damage, repair, suppressing the expression of oncogenes and stimulating the immune system (11)(12)(13)(14) . On the other hand, human diets increase the risk of cancer by about 20-30 % (14) .…”

Section: Introductionmentioning

confidence: 99%

Perceived role of hot food in the pathogenesis of oesophageal cancer: a qualitative study in the Arsi Zone, Oromia, Central Ethiopia

2021

View full text Add to dashboard Cite

Observational studies in Ethiopia have identified a positive association between hot wheat porridge consumption and oesophageal carcinoma. However, a single dietary intake cannot be a sufficient predictor of cancer among populations that have diverse dietary practices. The present study was carried out to explore the community's perspectives on the role of hot foods in the pathogenesis of oesophageal cancer in Ethiopia. Focus group discussions were conducted from May to August 2019 among purposefully selected 112 participants. Data were collected by using open-ended questions; memo writing, audio recordings and photo pictures. All tape-recorded interviews were transcribed verbatim and inductively coded using Atlas.ti Version 7.0.71 software. Finally, the analysis was performed according to the standard thematic framework analysis techniques. The finding showed that hot foods (porridge, coffee and soup) consumption patterns were perceived as the principal dietary risk of oesophageal cancer. Cooking in unventilated rooms, monotonous cereal-based foods, poor vegetable, and fruit intake, not taking milk with porridge, eating fast, swallowing large bolus of hot porridge and exposure to carcinogens in foods were regarded as predisposing dietary practices to oesophageal carcinoma. Socio-demographic, economic and cultural backgrounds were reported as the underlying risk factors associated with oesophageal cancer. There was a strong perception within the community that oesophageal cancer is linked to several but sequentially interlinked dietary and related practices. Cumulative thermal injuries from the consumptions of hot food could be the immediate dietary risk factors associated with increased risk of oesophageal cancer.

show abstract

“…Certain micronutrients such as vitamins C and E, zinc, and iron have proven efficacy against H. pylori infections, and thus can be helpful in modulating the immune response while decreasing the risk of carcinogenesis [ 59 , 60 ]. The scientific data support the great contribution of microbial species to the development of cancers attributable to infectious agents [ 61 ], and thus it is also possible that micronutrients may influence the composition of gut microbiota that would have direct effects on H. pylori -induced disease states [ 62 ].…”

Section: A Possible Link Of Micronutrients With Gi and Hepatic Cancersmentioning

confidence: 99%

“…A randomized clinical trial has been currently registered on (accessed on 12 February 2021) (NCT03819088) to evaluate the effectiveness of zinc supplementation in patients with GI cancers (gastric carcinoma, liver and intrahepatic bile duct carcinoma, unresectable esophageal carcinoma, and unresectable pancreatic carcinoma) that cannot be removed by surgery and are currently receiving chemotherapy. Moreover, the reciprocity in effects of zinc on H. pylori pathogenesis likely underpins the differences observed in gastric cancer risk [ 62 ].…”

Section: A Possible Link Of Micronutrients With Gi and Hepatic Cancersmentioning

confidence: 99%

Micronutrient Food Supplements in Patients with Gastro-Intestinal and Hepatic Cancers

Alam

Ullah

Santarcangelo

et al. 2021

IJMS

View full text Add to dashboard Cite

Colorectal carcinogenesis is the second most common cause of mortality across all types of malignancies, followed by hepatic and stomach cancers. Chemotherapy and radiotherapy are key approaches to treating cancer patients, but these carry major concerns, such as a high risk of side effects, poor accessibility, and the non-selective nature of chemotherapeutics. A number of natural products have been identified as countering various forms of cancer with fewer side effects. The potential impact of vitamins and minerals on long-term health, cognition, healthy development, bone formation, and aging has been supported by experimental and epidemiological studies. Successful treatment may thus be highly influenced by the nutritional status of patients. An insufficient diet could lead to detrimental effects on immune status and tolerance to treatment, affecting the ability of chemotherapy to destroy cancerous cells. In recent decades, most cancer patients have been taking vitamins and minerals to improve standard therapy and/or to decrease the undesirable side effects of the treatment together with the underlying disease. On the other hand, taking dietary supplements during cancer therapy may affect the effectiveness of chemotherapy. Thus, micronutrients in complementary oncology must be selected appropriately and should be taken at the right time. Here, the potential impact of micronutrients on gastro-intestinal and hepatic cancers is explored and their molecular targets are laid down.

show abstract

Micronutrients: A Double-Edged Sword in Microbe-Induced Gastric Carcinogenesis

Cited by 6 publications

References 43 publications

Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression

Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression

Perceived role of hot food in the pathogenesis of oesophageal cancer: a qualitative study in the Arsi Zone, Oromia, Central Ethiopia

Micronutrient Food Supplements in Patients with Gastro-Intestinal and Hepatic Cancers

Contact Info

Product

Resources

About