Micronutrient supplements for children after deworming

Hall, Andrew

doi:10.1016/s1473-3099(07)70084-1

Cited by 42 publications

(28 citation statements)

References 54 publications

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“…Additional education programs may also be needed complementary to nutrition and other health interventions. 37 We reported that multi-micronutrient fortified biscuits significantly reduced the prevalence of anemia and increased micronutrient status. 29 In this study, in-depth analysis of growth outcomes show that multi-micronutrient fortified biscuits only significantly improved MUAC but had no effect on growth in weight or height and four points of skin fold thickness (biceps, triceps, sub-scapular, and suprailiac).…”

Section: Discussionmentioning

confidence: 93%

Decreased Parasite Load and Improved Cognitive Outcomes Caused by Deworming and Consumption of Multi-Micronutrient Fortified Biscuits in Rural Vietnamese Schoolchildren

Nga

Winichagoon²,

Dijkhuizen³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Abstract. Micronutrient deficiencies are associated with impaired growth and cognitive function. A school-based fortification program might benefit schoolchildren but a high prevalence of parasite infestation might affect effectiveness. A randomized, double-blind, placebo-controlled 2 × 2 factorial trial was conducted to assess the efficacy of multimicronutrient fortified biscuits with or without de-worming on growth, cognitive function, and parasite load in Vietnamese schoolchildren. Schoolchildren (n = 510), 6-8 years of age were randomly allocated to receive albendazole or placebo at baseline and four months of multi-micronutrient fortified biscuits (FB) or non-fortified biscuits. Children receiving FB for four months scored higher on two cognitive tests: Raven's Colored Progressive Matrices and the Digit Span Forward test. Children receiving albendazole plus FB had the lowest parasite load after four months. In children receiving FB, midupper arm circumference was slightly improved (+0.082 cm) but there were no differences in other indexes of anthropometry. Combining multi-micronutrient fortified biscuits with de-worming is an effective strategy.

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Section: Discussionmentioning

confidence: 93%

Decreased Parasite Load and Improved Cognitive Outcomes Caused by Deworming and Consumption of Multi-Micronutrient Fortified Biscuits in Rural Vietnamese Schoolchildren

Nga

Winichagoon²,

Dijkhuizen³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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“…Parallel studies are examining the added benefits of micronutrient supplementation, particularly in combating the anemias associated with hookworm and schistosomiasis (148,149). Other studies are specifically examining the impact of infection among women who are pregnant and women of child-bearing age, risk groups who are often excluded from MDA because of fears of fetal toxicity (136,150,151), or they are examining the early developmental effects of helminthic infections among preschool children (152).…”

Section: Global Control Of Helminthiases and Clinical Research Imperamentioning

confidence: 99%

Helminth infections: the great neglected tropical diseases

et al. 2008

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Helminths are parasitic worms. They are the most common infectious agents of humans in developing countries and produce a global burden of disease that exceeds better-known conditions, including malaria and tuberculosis. As we discuss here, new insights into fundamental helminth biology are accumulating through newly completed genome projects and the nascent application of transgenesis and RNA interference technologies. At the same time, our understanding of the dynamics of the transmission of helminths and the mechanisms of the Th2-type immune responses that are induced by infection with these parasitic worms has increased markedly. Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans.

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“…STHs have also been associated with stunted growth and impaired cognitive function in children. 4 Hookworm causes anaemia and is often associated with A. lumbricoides and Trichuris trichiura infections. [5][6][7] In many cases children living in poverty are parasitised with all three STHs.…”

Section: Introductionmentioning

confidence: 99%

Soil-transmitted helminth infections and risk factors in preschool children in southern rural Lao People's Democratic Republic

Kounnavong

Vonglokham

Houamboun

et al. 2011

Transactions of the Royal Society of Tropical Medicine and Hygi

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a b s t r a c tThe current widespread school-based control of soil-transmitted helminth (STH) infections is also advocated for preschool children. The objective of this study was to assess infection with STHs as well as their determinants in preschool children (<60 months) in southern rural Lao People's Democratic Republic (Lao PDR). A cluster survey was carried out from October to December 2006 in three districts of Savannakhet Province. The prevalence of Ascaris lumbricoides, hookworm and Trichuris trichiura was 27.4% (95% CI 27.0-27.6%), 10.9% (95% CI 10.7-11.0%) and 10.9% (95% CI 10.7-11.1%), respectively. Of the children studied, 28.4% had a monoparasitic infection and 9.3% had a polyparasitic infection. Older children had a higher risk for hookworm infection [odds ratio (OR) = 1.75, 95% CI 1.03-3.01; P = 0.041] and multiple infections (OR = 1.81, 95% CI 1.01-3.20; P = 0.044). Low socioeconomic status was associated with A. lumbricoides (OR = 0.61, 95% CI 0.38-0.98; P = 0.043) and monoparasitic infections (OR = 0.62, 95% CI 0.38-0.99; P = 0.049). In Lao PDR, deworming of preschool children is warranted. Preventive measures should address important risk factors. Health education regarding personal hygiene, appropriate water management and the construction and proper use of latrines are additional essential elements.

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Micronutrient supplements for children after deworming

Cited by 42 publications

References 54 publications

Decreased Parasite Load and Improved Cognitive Outcomes Caused by Deworming and Consumption of Multi-Micronutrient Fortified Biscuits in Rural Vietnamese Schoolchildren

Decreased Parasite Load and Improved Cognitive Outcomes Caused by Deworming and Consumption of Multi-Micronutrient Fortified Biscuits in Rural Vietnamese Schoolchildren

Helminth infections: the great neglected tropical diseases

Soil-transmitted helminth infections and risk factors in preschool children in southern rural Lao People's Democratic Republic

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