Micronutrient status and leukocyte telomere length in school-age Colombian children

Flannagan, Kerry S.; Bowman, Alison A.; Mora‐Plazas, Mercedes; Marín, Constanza; Rentschler, Katie M.; Rozek, Laura S.; Villamor, Eduardo

doi:10.1007/s00394-019-01966-x

Cited by 15 publications

(17 citation statements)

References 51 publications

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“…All the included studies measured the telomere length from leukocytes. Three studies ( Lamprokostopoulou et al, 2019 ; Flannagan et al, 2020 ; Todendi et al, 2020 ) had been performed in a school setting and four studies ( Al-Attas et al, 2010 ; Zhu et al, 2014 ; Wojcicki et al, 2016a ; Theall et al, 2019 ) were community-based. Four studies ( Al-Attas et al, 2010 ; Zhu et al, 2014 ; Wojcicki et al, 2016a ; Lamprokostopoulou et al, 2019 ) included only youth with obesity, while three studies ( Theall et al, 2019 ; Flannagan et al, 2020 ; Todendi et al, 2020 ) included children and adolescents with obesity.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies ( Lamprokostopoulou et al, 2019 ; Flannagan et al, 2020 ; Todendi et al, 2020 ) had been performed in a school setting and four studies ( Al-Attas et al, 2010 ; Zhu et al, 2014 ; Wojcicki et al, 2016a ; Theall et al, 2019 ) were community-based. Four studies ( Al-Attas et al, 2010 ; Zhu et al, 2014 ; Wojcicki et al, 2016a ; Lamprokostopoulou et al, 2019 ) included only youth with obesity, while three studies ( Theall et al, 2019 ; Flannagan et al, 2020 ; Todendi et al, 2020 ) included children and adolescents with obesity. Two studies ( Wojcicki et al, 2016a ; Theall et al, 2019 ) had been performed in the United States, one in Brazil ( Todendi et al, 2020 ), one in Greece ( Lamprokostopoulou et al, 2019 ), one in Colombia ( Flannagan et al, 2020 ), one in Georgia ( Zhu et al, 2014 ), and one in Saudi Arabia ( Al-Attas et al, 2010 ).…”

Section: Resultsmentioning

confidence: 99%

“…Telomeres are non-coding repeated sequences of genome that are responsible in maintaining DNA integrity and stability during each division ( Flannagan et al, 2020 ; Tang et al, 2020 ). With each cell division, the telomere length shortens and this shortening does not occur at a constant rate, but rather, rapidly declines from birth through age 4 ( Rufer et al, 1999 ; Gasmi et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…In a meta-analysis conducted by Lin L et al, not all the eligible studies were included possibly due to the time of publication ( Zhu et al, 2014 ; Flannagan et al, 2020 ), and the LTL unit in all the included studies was not identical. For example, they included the study by Buxton L et al in the meta-analysis and reported the log T/S ratio and not the unchanged variable.…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Leukocyte telomere length and obesity in children and adolescents: A systematic review and meta-analysis

et al. 2022

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Background: Several studies have revealed the negative effects of adiposity on telomere length shortening. However, the results of the studies assessing the negative relationship between obesity and leukocyte telomere length (LTL) are not consistent. This systematic review and meta-analysis are aimed to pool the results of articles assessing the relationship between obesity and LTL among children and adolescents.Methods: To retrieve the related studies, four online databases including PubMed, Embase, ProQuest, and Scopus were searched until May 2022. Observational studies evaluating the relationship between obesity and LTL among apparently healthy children and adolescents (aged ≤18 years) were included in the study. We considered the studies that had reported a mean ± standard deviation of LTL. The random-effects model was used to assess the pooled weighted mean difference (WMD) and a 95% confidence interval (CI).Results: The search yielded seven studies from an initial 3,403 records identified. According to the results of seven articles with 4,546 participants, obesity was associated with LTL shortening among children and adolescents (WMD = −0.081; 95% CI: −0.137 to −0.026; p = 0.004; I2 = 99.9%). Also, no publication bias was observed. According to the results of subgrouping, significant results were only attributed to the studies conducted in Europe, with high quality scores, among overweight and obese adolescents, with a baseline LTL lower than 1, and performed in community-based school settings. Also, according to the subgrouping and meta-regression results, the obesity definition criteria and baseline LTL were the possible sources of between-study heterogeneity.Conclusion: We observed shorter LTL among overweight and obese children and adolescents. To obtain more reliable results, further longitudinal prospective studies with large sample sizes and more consistent and accurate definitions of obesity are required.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Leukocyte telomere length and obesity in children and adolescents: A systematic review and meta-analysis

et al. 2022

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“…We found no previous studies on the impact of vitamin B-12 on placental or cord blood TL, but an inverse association between maternal vitamin B-12 status and the expression of placental angiogenesis-related genes has been reported ( 49 ). In a study in Colombian children, plasma vitamin B-12 was found to be positively associated with leucocyte TL in girls but not boys ( 50 ). Thus, more research in this area is warranted, as vitamin B-12 deficiency is prevalent in populations with low meat intake.…”

Section: Discussionmentioning

confidence: 94%

Placental and Cord Blood Telomere Length in Relation to Maternal Nutritional Status

Vahter

Broberg

Harari

2020

The Journal of Nutrition

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Background The uterine environment may be important for the chromosomal telomere length (TL) at birth, which, in turn, influences disease susceptibility throughout life. However, little is known about the importance of specific nutritional factors. Objectives We assessed the impact of multiple maternal nutritional factors on TL in placenta and cord blood. Methods In a population-based mother–child cohort in northwestern Argentina, we measured maternal weight, BMI, body fat percentage (BFP), and several nutrients [selenium, magnesium, calcium, zinc, manganese, iodine, vitamin B-12, folate, 25-hydroxycholecalciferol (25(OH)D3)], hemoglobin, and homocysteine in maternal whole blood, serum, plasma, or urine during pregnancy (mean gestational week 27). We measured the relative TL (rTL) in placenta (n = 99) and cord blood (n = 98) at delivery by real-time PCR. Associations were evaluated by multivariable-adjusted linear regression. Results The women's prepregnancy BMI (kg/m2; mean ± SD: 23.7 ± 4.1), body weight (55.4 ± 9.9 kg), and BFP (29.9 ± 5.5%), but not height (153 ± 5.3 cm), were inversely associated with placental rTL (P < 0.01 for all), with ∼0.5 SD shorter rTL for an IQR increase in prepregnancy body weight, BMI, or BFP. Also, impedance-based BFP, but not lean body mass, in the third trimester was associated with shorter placental rTL. In addition, serum vitamin B-12 (232 ± 96 pmol/L) in pregnancy (P = 0.038), but not folate or homocysteine, was associated with shorter placental rTL (0.2 SD for an IQR increase). In contrast, plasma 25(OH)D3 (46 ± 15 nmol/L) was positively associated with placental rTL (P < 0.01), which increased by 0.4 SD for an IQR increase in 25(OH)D3. No clear associations of the studied maternal nutritional factors were found with cord blood rTL. Conclusions Maternal BMI, BFP, and vitamin B-12 were positively associated, whereas 25(OH)D3 was inversely associated, with placental TL. No association was observed with cord blood TL. Future studies should elucidate the role of placental TL for child health.

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Leukocyte telomere length predicts subsequent infectious morbidity among Colombian schoolchildren

Lee

Mora‐Plazas

Marín

et al. 2023

American J Hum Biol

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ObjectiveTelomere length (TL) attrition is related to chronic disease risk. However, less is known on whether TL predicts infectious outcomes, especially in childhood. We examined whether leukocyte TL (LTL) was associated with subsequent infectious morbidity in schoolchildren.MethodsWe assessed LTL in 717 Colombian children 5–12 years‐old at the beginning of a school year and followed them through the year for daily occurrence of common infection symptoms and doctor visits. We estimated adjusted incidence rate ratios (IRR) with 95% confidence intervals (CI) of gastrointestinal and respiratory syndromes for quartiles of standardized LTL Z score and per unit LTL Z score.ResultsA longer LTL was associated with increased incidence of all infectious morbidity syndromes considered. Adjusted IRR (95% CI) per unit LTL Z score were 1.55 (1.20, 2.00) for diarrhea with vomiting, 1.34 (1.13, 1.60) for cough with fever, 1.70 (1.28, 2.28) for ear infection, and 1.66 (1.36, 2.02) for doctor visits with symptoms.ConclusionsLonger LTL is related to increased incidence of common infectious morbidities in middle childhood.

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Micronutrient status and leukocyte telomere length in school-age Colombian children

Cited by 15 publications

References 51 publications

RETRACTED: Leukocyte telomere length and obesity in children and adolescents: A systematic review and meta-analysis

RETRACTED: Leukocyte telomere length and obesity in children and adolescents: A systematic review and meta-analysis

Placental and Cord Blood Telomere Length in Relation to Maternal Nutritional Status

Leukocyte telomere length predicts subsequent infectious morbidity among Colombian schoolchildren

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